Search Results - "Sharp, Geoffrey W.G"

Stimulation of Insulin Release by Glucose Is Associated With an Increase in the Number of Docked Granules in the β-Cells of Rat Pancreatic Islets by STRAUB, Susanne G, SHANMUGAM, Geetha, SHARP, Geoffrey W. G

“…Stimulation of Insulin Release by Glucose Is Associated With an Increase in the Number of Docked Granules in the β-Cells of Rat Pancreatic Islets Susanne G…”
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Onion component, isoalliin, stimulates feeding and activates the arcuate nucleus neuropeptide Y, ghrelin- and Ninjin'yoeito-responsive neurons by Wang, Lei, Han, Wanxin, Iwasaki, Yusaku, Yermek, Rakhat, Sharp, Geoffrey W.G., Seino, Yutaka, Yada, Toshihiko

“…Appetite loss or anorexia substantially decreases the quality of life in patients with cancer, depression and gastrointestinal disorders, and can lead to…”
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Intracellular pH Plays a Critical Role in Glucose-Induced Time-Dependent Potentiation of Insulin Release in Rat Islets by GUNAWARDANA, Subhadra C, SHARP, Geoffrey W. G

“…Intracellular pH Plays a Critical Role in Glucose-Induced Time-Dependent Potentiation of Insulin Release in Rat Islets Subhadra C. Gunawardana and Geoffrey…”
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Stimulation of Insulin Secretion by Denatonium, One of the Most Bitter-Tasting Substances Known by STRAUB, Susanne G, MULVANEY-MUSA, Jennifer, YAJIMA, Hiroki, WEILAND, Gregory A, SHARP, Geoffrey W. G

“…Stimulation of Insulin Secretion by Denatonium, One of the Most Bitter-Tasting Substances Known Susanne G. Straub , Jennifer Mulvaney-Musa , Hiroki Yajima ,…”
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Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion by BRATANOVA-TOCHKOVA, Troitza K, CHENG, Haiying, DANIEL, Samira, GUNAWARDANA, Subhadra, LIU, Yi-Jia, MULVANEY-MUSA, Jennifer, SCHERMERHORN, Thomas, STRAUB, Susanne G, YAJIMA, Hiroki, SHARP, Geoffrey W. G

“…The insulin secretory response by pancreatic beta-cells to an acute "square wave" stimulation by glucose is characterized by a first phase that occurs promptly…”
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Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion by DANIEL, S, NODA, M, STRAUB, S. G, SHARP, G. W. G

“…Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion. S Daniel , M Noda , S G Straub and G W Sharp…”
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Glucose action `beyond ionic events' in the pancreatic β cell by Aizawa, Toru, Komatsu, Mitsuhisa, Asanuma, Nahoko, Sato, Yoshihiko, Sharp, Geoffrey W.G

“…For normal glucose homeostasis, insulin release by the pancreatic β cell is vital. Until recently, it was thought that glucose-induced ionic events, such as…”
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Massive Augmentation of Stimulated Insulin Secretion Induced by Fatty Acid–Free BSA in Rat Pancreatic Islets by STRAUB, Susanne G, SHARP, Geoffrey W. G

“…Massive Augmentation of Stimulated Insulin Secretion Induced by Fatty Acid–Free BSA in Rat Pancreatic Islets Susanne G. Straub and Geoffrey W. G. Sharp From…”
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A Wortmannin-sensitive Signal Transduction Pathway Is Involved in the Stimulation of Insulin Release by Vasoactive Intestinal Polypeptide and Pituitary Adenylate Cyclase-activating Polypeptide (∗) by Straub, Susanne G., Sharp, Geoffrey W.G.

“…Vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase-activating polypeptide-27 (PACAP-27), and PACAP-38 stimulated insulin release with EC50…”
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The Effects of Cerulenin, an Inhibitor of Protein Acylation, on the Two Phases of Glucose-Stimulated Insulin Secretion by STRAUB, Susanne G, YAJIMA, Hiroki, KOMATSU, Mitsuhisa, AIZAWA, Toru, SHARP, Geoffrey W. G

“…The potential role of protein acylation in the control of biphasic insulin secretion has been studied in isolated rat pancreatic islets. The protein acylation…”
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The βHC-9 Pancreatic β-Cell Line Preserves the Characteristics of Progenitor Mouse Islets by Noda, Mitsuhiko, Komatsu, Mitsuhisa, Sharp, Geoffrey W.G

“…βHC-9 is a pancreatic β-cell line that is derived from the hyperplastic islets of transgenic mice that express the simian virus 40 tumor antigen gene in the…”
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Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells by Tang, S H, Sharp, G W

“…Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells. S H Tang and G W Sharp Department of Pharmacology,…”
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Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets by STRAUB, S. G, JAMES, R. F. L, DUNNE, M. J, SHARP, G. W. G

“…Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets. S G Straub , R F James , M J Dunne and G W Sharp Department…”
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CO2/HCO3−- and Calcium-regulated Soluble Adenylyl Cyclase as a Physiological ATP Sensor by Zippin, Jonathan H., Chen, Yanqiu, Straub, Susanne G., Hess, Kenneth C., Diaz, Ana, Lee, Dana, Tso, Patrick, Holz, George G., Sharp, Geoffrey W.G., Levin, Lonny R., Buck, Jochen

“…The second messenger molecule cAMP is integral for many physiological processes. In mammalian cells, cAMP can be generated from hormone- and G…”
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Identification of muscarinic receptor subtypes in RINm5F cells by means of polymerase chain reaction, subcloning, and DNA sequencing by SHAO HUA TANG, SHARP, G. W. G

“…Carbachol can stimulate insulin release in RINm5F cells by a mechanism that does not involve the elevation of cytosolic free Ca2+ concentrations or the…”
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Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins by Straub, Susanne G, Sharp, Geoffrey W G

“…Norepinephrine has for many years been known to have three major effects on the pancreatic β-cell which lead to the inhibition of insulin release. These are…”
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Gi2 and Gi3 proteins mediate the inhibition of adenylyl cyclase by galanin in the RINm5F cell by MCDERMOTT, A. M, SHARP, G. W. G

“…Inhibition of adenylyl cyclase activity is one of at least four mechanisms by which the neuropeptide galanin inhibits insulin secretion from pancreatic…”
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Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release by Spégel, Peter, Sharoyko, Vladimir V, Goehring, Isabel, Danielsson, Anders P H, Malmgren, Siri, Nagorny, Cecilia L F, Andersson, Lotta E, Koeck, Thomas, Sharp, Geoffrey W G, Straub, Susanne G, Wollheim, Claes B, Mulder, Hindrik

“…Insulin secretion is coupled with changes in β-cell metabolism. To define this process, 195 putative metabolites, mitochondrial respiration, NADP+, NADPH and…”
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Prostaglandin E1 inhibits endocytosis in the β-cell endocytosis by Zhao, Ying, Fang, Qinghua, Straub, Susanne G, Lindau, Manfred, Sharp, Geoffrey W G

“…Prostaglandins inhibit insulin secretion in a manner similar to that of norepinephrine (NE) and somatostatin. As NE inhibits endocytosis as well as exocytosis,…”
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Noradrenaline inhibits exocytosis via the G protein βγ subunit and refilling of the readily releasable granule pool via the αi1/2 subunit by Zhao, Ying, Fang, Qinghua, Straub, Susanne G., Lindau, Manfred, Sharp, Geoffrey W. G.

“…The molecular mechanisms responsible for the ‘distal’ effect by which noradrenaline (NA) blocks exocytosis in the β‐cell were examined by whole‐cell and…”
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