Search Results - "Sharov, Victor"

γ-Synuclein: Seeding of α-Synuclein Aggregation and Transmission between Cells by Surgucheva, Irina, Sharov, Victor S, Surguchov, Andrei

“…Protein misfolding and aggregation is a ubiquitous phenomenon associated with a wide range of diseases. The synuclein family comprises three small naturally…”
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SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model by Harraz, Maged M, Marden, Jennifer J, Zhou, Weihong, Zhang, Yulong, Williams, Aislinn, Sharov, Victor S, Nelson, Kathryn, Luo, Meihui, Paulson, Henry, Schöneich, Christian, Engelhardt, John F

“…Neurodegeneration in familial amyotrophic lateral sclerosis (ALS) is associated with enhanced redox stress caused by dominant mutations in superoxide…”
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Mass spectrometry of protein modifications by reactive oxygen and nitrogen species by Schöneich, Christian, Sharov, Victor S.

“…The modification of proteins by reactive oxygen and nitrogen species plays an important role in various biologic processes involving protein activation and…”
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Heat-shock proteins attenuate SERCA inactivation by the anti-apoptotic protein Bcl-2: possible implications for the ER Ca2+-mediated apoptosis by Dremina, Elena S, Sharov, Victor S, Schöneich, Christian

“…We have demonstrated previously that Bcl-2 and Bcl-2Δ21, a C-terminally truncated Bcl-2 sequence, inactivate SERCA (sarcoplasmic/endoplasmic reticulum…”
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S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide by Adachi, Takeshi, Cohen, Richard A, Weisbrod, Robert M, Pimentel, David R, Ying, Jia, Sharov, Victor S, Schöneich, Christian

“…Nitric oxide (NO) physiologically stimulates the sarco/endoplasmic reticulum calcium (Ca(2+)) ATPase (SERCA) to decrease intracellular Ca(2+) concentration and…”
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Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction by Duda, Monika K., O'Shea, Karen M., Tintinu, Anselm, Xu, Wenhong, Khairallah, Ramzi J., Barrows, Brian R., Chess, David J., Azimzadeh, Agnes M., Harris, William S., Sharov, Victor G., Sabbah, Hani N., Stanley, William C.

“…Aims Clinical studies suggest that intake of ω-3 polyunsaturated fatty acids (ω-3 PUFA) may lower the incidence of heart failure. Dietary supplementation with…”
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Identification of Oxidation Sites and Covalent Cross-Links in Metal Catalyzed Oxidized Interferon Beta-1a: Potential Implications for Protein Aggregation and Immunogenicity by Torosantucci, Riccardo, Sharov, Victor S, van Beers, Miranda, Brinks, Vera, Schöneich, Christian, Jiskoot, Wim

“…Oxidation via Cu2+/ascorbate of recombinant human interferon beta-1a (IFNβ1a) leads to highly immunogenic aggregates, however it is unknown which amino acids…”
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Quantitative mapping of oxidation-sensitive cysteine residues in SERCA in vivo and in vitro by HPLC-electrospray-tandem MS: selective protein oxidation during biological aging by Sharov, Victor S, Dremina, Elena S, Galeva, Nadezhda A, Williams, Todd D, Schöneich, Christian

“…The selective reversible S-glutathiolation of specific SERCA (sarcoplasmic/endoplasmic-reticulum Ca2+-ATPase) cysteine residues represents a novel physiologic…”
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Therapy With Cardiac Contractility Modulation Electrical Signals Improves Left Ventricular Function and Remodeling in Dogs With Chronic Heart Failure by Imai, Makoto, MD, Rastogi, Sharad, MD, Gupta, Ramesh C., PhD, Mishra, Sudhish, PhD, Sharov, Victor G., MD, PhD, Stanley, William C., PhD, Mika, Yuval, PhD, Rousso, Benny, PhD, Burkhoff, Daniel, MD, PhD, FACC, Ben-Haim, Shlomo, MD, PhD, Sabbah, Hani N., PhD, FACC

“…Therapy With Cardiac Contractility Modulation Electrical Signals Improves Left Ventricular Function and Remodeling in Dogs With Chronic Heart Failure Makoto…”
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Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure by Sharov, Victor G, Todor, Anastassia, Khanal, Sanjaya, Imai, Makoto, Sabbah, Hani N

“…Abstract We used isolated cardiomyocytes to investigate a possible role of mitochondrial permeability transition pore in mitochondrial abnormalities associated…”
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Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure by Rastogi, Sharad, Sharov, Victor G, Mishra, Sudhish, Gupta, Ramesh C, Blackburn, Brent, Belardinelli, Luiz, Stanley, William C, Sabbah, Hani N

“…Acute intravenous infusion of ranolazine (Ran), an anti-ischemic/antiangina drug, was previously shown to improve left ventricular (LV) ejection fraction (EF)…”
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Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca2+-ATPase activity and perturb Ca2+ homeostasis in human coronary artery endothelial cells by Cook, Naomi L., Viola, Helena M., Sharov, Victor S., Hool, Livia C., Schöneich, Christian, Davies, Michael J.

“…The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) plays a critical role in Ca2+ homeostasis via sequestration of this ion in the sarco/endoplasmic reticulum…”
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SOMSpec as a General Purpose Validated Self-Organising Map Tool for Rapid Protein Secondary Structure Prediction From Infrared Absorbance Data by Pinto Corujo, Marco, Olamoyesan, Adewale, Tukova, Anastasiia, Ang, Dale, Goormaghtigh, Erik, Peterson, Jason, Sharov, Victor, Chmel, Nikola, Rodger, Alison

“…A protein's structure is the key to its function. As protein structure can vary with environment, it is important to be able to determine it over a wide range…”
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A methodology for simultaneous fluorogenic derivatization and boronate affinity enrichment of 3-nitrotyrosine-containing peptides by Dremina, Elena S., Li, Xiaobao, Galeva, Nadezhda A., Sharov, Victor S., Stobaugh, John F., Schöneich, Christian

“…We synthesized and characterized a new tagging reagent, (3 R,4 S)-1-(4-(aminomethyl)phenylsulfonyl)pyrrolidine-3,4-diol (APPD), for the selective fluorogenic…”
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3-Nitrotyrosine Modification of SERCA2a in the Aging Heart:  A Distinct Signature of the Cellular Redox Environment by Knyushko, Tatyana V, Sharov, Victor S, Williams, Todd D, Schöneich, Christian, Bigelow, Diana J

“…In the aging heart, decreased rates of calcium transport mediated by the SERCA2a isoform of the sarcoplasmic reticulum (SR) Ca-ATPase are responsible for the…”
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Low Carbohydrate/High-Fat Diet Attenuates Cardiac Hypertrophy, Remodeling, and Altered Gene Expression in Hypertension by Okere, Isidore C, Young, Martin E, McElfresh, Tracy A, Chess, David J, Sharov, Victor G, Sabbah, Hani N, Hoit, Brian D, Ernsberger, Paul, Chandler, Margaret P, Stanley, William C

“…The effects of dietary fat intake on the development of left ventricular hypertrophy and accompanying structural and molecular remodeling in response to…”
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Cysteine-674 oxidation and degradation of sarcoplasmic reticulum Ca2+ ATPase in diabetic pig aorta by Ying, Jia, Sharov, Victor, Xu, Shanqin, Jiang, Bingbing, Gerrity, Ross, Schöneich, Christian, Cohen, Richard A.

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Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin by Okere, Isidore C, Chandler, Margaret P, McElfresh, Tracy A, Rennison, Julie H, Sharov, Victor, Sabbah, Hani N, Tserng, Kou-Yi, Hoit, Brian D, Ernsberger, Paul, Young, Martin E, Stanley, William C

“…Fatty acids are the primary fuel for the heart and are ligands for peroxisome proliferator-activated receptors (PPARs), which regulate the expression of genes…”
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Chronic Monotherapy With Rosuvastatin Prevents Progressive Left Ventricular Dysfunction and Remodeling in Dogs With Heart Failure by Zacà, Valerio, MD, Rastogi, Sharad, MD, Imai, Makoto, MD, Wang, Mengjun, MD, Sharov, Victor G., PhD, Jiang, Alice, MD, Goldstein, Sidney, MD, FACC, Sabbah, Hani N., PhD, FACC

“…Chronic Monotherapy With Rosuvastatin Prevents Progressive Left Ventricular Dysfunction and Remodeling in Dogs With Heart Failure Valerio Zacà, Sharad Rastogi,…”
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Effects of long-term monotherapy with eplerenone, a novel aldosterone blocker, on progression of left ventricular dysfunction and remodeling in dogs with heart failure by SUZUKI, George, MORITA, Hideaki, MISHIMA, Takayuki, SHAROV, Victor G, TODOR, Anastassia, TANHEHCO, Elaine J, RUDOLPH, Amy E, MCMAHON, Ellen G, GOLDSTEIN, Sidney, SABBAH, Hani N

“…In heart failure (HF), aldosterone has been implicated in the formation of reactive interstitial fibrosis, a maladaptation that contributes to left ventricular…”
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