Search Results - "Sharonov, George"

B cells, plasma cells and antibody repertoires in the tumour microenvironment by Sharonov, George V., Serebrovskaya, Ekaterina O., Yuzhakova, Diana V., Britanova, Olga V., Chudakov, Dmitriy M.

“…Recent data show that B cells and plasma cells located in tumours or in tumour-draining lymph nodes can have important roles in shaping antitumour immune…”
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KillerOrange, a Genetically Encoded Photosensitizer Activated by Blue and Green Light by Sarkisyan, Karen S, Zlobovskaya, Olga A, Gorbachev, Dmitry A, Bozhanova, Nina G, Sharonov, George V, Staroverov, Dmitriy B, Egorov, Evgeny S, Ryabova, Anastasia V, Solntsev, Kyril M, Mishin, Alexander S, Lukyanov, Konstantin A

“…Genetically encoded photosensitizers, proteins that produce reactive oxygen species when illuminated with visible light, are increasingly used as optogenetic…”
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Local fitness landscape of the green fluorescent protein by Sarkisyan, Karen S., Bolotin, Dmitry A., Meer, Margarita V., Usmanova, Dinara R., Mishin, Alexander S., Sharonov, George V., Ivankov, Dmitry N., Bozhanova, Nina G., Baranov, Mikhail S., Soylemez, Onuralp, Bogatyreva, Natalya S., Vlasov, Peter K., Egorov, Evgeny S., Logacheva, Maria D., Kondrashov, Alexey S., Chudakov, Dmitry M., Putintseva, Ekaterina V., Mamedov, Ilgar Z., Tawfik, Dan S., Lukyanov, Konstantin A., Kondrashov, Fyodor A.

“…Comprehensive genotype–phenotype mapping of the green fluorescent protein shows that the local fitness peak is narrow, shaped by a high prevalence of epistatic…”
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Pinpointing the tumor-specific T cells via TCR clusters by Goncharov, Mikhail M, Bryushkova, Ekaterina A, Sharaev, Nikita I, Skatova, Valeria D, Baryshnikova, Anastasiya M, Sharonov, George V, Karnaukhov, Vadim, Vakhitova, Maria T, Samoylenko, Igor V, Demidov, Lev V, Lukyanov, Sergey, Chudakov, Dmitriy M, Serebrovskaya, Ekaterina O

“…Adoptive cell transfer (ACT) is a promising approach to cancer immunotherapy, but its efficiency fundamentally depends on the extent of tumor-specific T cell…”
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Quantitative profiling of immune repertoires for minor lymphocyte counts using unique molecular identifiers by Egorov, Evgeny S, Merzlyak, Ekaterina M, Shelenkov, Andrew A, Britanova, Olga V, Sharonov, George V, Staroverov, Dmitriy B, Bolotin, Dmitriy A, Davydov, Alexey N, Barsova, Ekaterina, Lebedev, Yuriy B, Shugay, Mikhail, Chudakov, Dmitriy M

“…Emerging high-throughput sequencing methods for the analyses of complex structure of TCR and BCR repertoires give a powerful impulse to adaptive immunity…”
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FLIM of NAD(P)H in Lymphatic Nodes Resolves T-Cell Immune Response to the Tumor by Izosimova, Anna V, Shirmanova, Marina V, Shcheslavskiy, Vladislav I, Sachkova, Daria A, Mozherov, Artem M, Sharonov, George V, Zagaynova, Elena V, Yuzhakova, Diana V

“…Assessment of T-cell response to the tumor is important for diagnosis of the disease and monitoring of therapeutic efficacy. For this, new non-destructive…”
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Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF by Tyurin-Kuzmin, Pyotr A, Zhdanovskaya, Nadezhda D, Sukhova, Anna A, Sagaradze, George D, Albert, Eugene A, Ageeva, Ludmila V, Sharonov, George V, Vorotnikov, Alexander V, Tkachuk, Vsevolod A

“…Platelet derived growth factor (PDGF) orchestrates wound healing and tissue regeneration by regulating recruitment of the precursor mesenchymal stromal cells…”
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Green Fluorescent Protein with Anionic Tryptophan-Based Chromophore and Long Fluorescence Lifetime by Sarkisyan, Karen S., Goryashchenko, Alexander S., Lidsky, Peter V., Gorbachev, Dmitry A., Bozhanova, Nina G., Gorokhovatsky, Andrey Yu, Pereverzeva, Alina R., Ryumina, Alina P., Zherdeva, Victoria V., Savitsky, Alexander P., Solntsev, Kyril M., Bommarius, Andreas S., Sharonov, George V., Lindquist, Jake R., Drobizhev, Mikhail, Hughes, Thomas E., Rebane, Aleksander, Lukyanov, Konstantin A., Mishin, Alexander S.

“…Spectral diversity of fluorescent proteins, crucial for multiparameter imaging, is based mainly on chemical diversity of their chromophores. Recently we have…”
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Genetically encoded far-red fluorescent sensors for caspase-3 activity by Zlobovskaya, Olga A, Sergeeva, Tatiana F, Shirmanova, Marina V, Dudenkova, Varvara V, Sharonov, George V, Zagaynova, Elena V, Lukyanov, Konstantin A

“…Caspase-3 is a key effector caspase that is activated in both extrinsic and intrinsic pathways of apoptosis. Available fluorescent sensors for caspase-3…”
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Deciphering Repertoire of B16 Melanoma Reactive TCRs by Immunization, In Vitro Restimulation and Sequencing of IFNγ-Secreting T Cells by Izosimova, Anna V., Yuzhakova, Diana V., Skatova, Valeria D., Volchkova, Lilia N., Zagainova, Elena V., Chudakov, Dmitry M., Sharonov, George V.

“…Recent advances in cancer immunotherapy have great promise for the treatment of solid tumors. One of the key limiting factors that hamper the decoding of…”
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Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors by Davydov, Alexey N, Obraztsova, Anna S, Lebedin, Mikhail Y, Turchaninova, Maria A, Staroverov, Dmitriy B, Merzlyak, Ekaterina M, Sharonov, George V, Kladova, Olga, Shugay, Mikhail, Britanova, Olga V, Chudakov, Dmitriy M

“…Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination. In…”
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RNA-Seq-Based TCR Profiling Reveals Persistently Increased Intratumoral Clonality in Responders to Anti-PD-1 Therapy by Zhigalova, Ekaterina A, Izosimova, Anna I, Yuzhakova, Diana V, Volchkova, Lilia N, Shagina, Irina A, Turchaninova, Maria A, Serebrovskaya, Ekaterina O, Zagaynova, Elena V, Chudakov, Dmitriy M, Sharonov, George V

“…Substantial effort is being invested in the search for peripheral or intratumoral T cell receptor (TCR) repertoire features that could predict the response to…”
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Expression of EMT-Related Genes in Hybrid E/M Colorectal Cancer Cells Determines Fibroblast Activation and Collagen Remodeling by Druzhkova, Irina, Shirmanova, Marina, Ignatova, Nadezhda, Dudenkova, Varvara, Lukina, Maria, Zagaynova, Elena, Safina, Dina, Kostrov, Sergey, Didych, Dmitry, Kuzmich, Alexey, Sharonov, George, Rakitina, Olga, Alekseenko, Irina, Sverdlov, Eugene

“…Collagen, the main non-cellular component of the extracellular matrix (ECM), is profoundly reorganized during tumorigenesis and has a strong impact on tumor…”
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Local angiotensin II promotes adipogenic differentiation of human adipose tissue mesenchymal stem cells through type 2 angiotensin receptor by Sysoeva, Veronika Y., Ageeva, Liudmila V., Tyurin-Kuzmin, Pyotr A., Sharonov, George V., Dyikanov, Daniyar T., Kalinina, Natalia I., Tkachuk, Vsevolod A.

“…Obesity is often associated with high systemic and local activity of renin-angiotensin system (RAS). Mesenchymal stem cells of adipose tissue are the main…”
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Point Mutations in Dimerization Motifs of the Transmembrane Domain Stabilize Active or Inactive State of the EphA2 Receptor Tyrosine Kinase by Sharonov, George V., Bocharov, Eduard V., Kolosov, Peter M., Astapova, Maria V., Arseniev, Alexander S., Feofanov, Alexey V.

“…The EphA2 receptor tyrosine kinase plays a central role in the regulation of cell adhesion and guidance in many human tissues. The activation of EphA2 occurs…”
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Molecular Mechanisms of Immunomodulation Properties of Mesenchymal Stromal Cells: A New Insight into the Role of ICAM-1 by Sharonov, George, Suzdaltseva, Yulia, Romanov, Аndrey, Goryunov, Кirill, Rubtsov, Yury, Tkachuk, V. A.

“…Mesenchymal stromal cells (MSC) control excessive inflammation and create a microenvironment for tissue repair protecting from chronic inflammation and tissue…”
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Light-induced blockage of cell division with a chromatin-targeted phototoxic fluorescent protein by Serebrovskaya, Ekaterina O, Gorodnicheva, Tatiana V, Ermakova, Galina V, Solovieva, Elena A, Sharonov, George V, Zagaynova, Elena V, Chudakov, Dmitriy M, Lukyanov, Sergey, Zaraisky, Andrey G, Lukyanov, Konstantin A

“…Proteins of the GFP (green fluorescent protein) family are widely used as passive reporters for live cell imaging. In the present study we used H2B (histone…”
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p63 and p73 repress CXCR5 chemokine receptor gene expression in p53-deficient MCF-7 breast cancer cells during genotoxic stress by Mitkin, Nikita A., Muratova, Alisa M., Sharonov, George V., Korneev, Kirill V., Sviriaeva, Ekaterina N., Mazurov, Dmitriy, Schwartz, Anton M., Kuprash, Dmitry V.

“…Many types of chemotherapeutic agents induce of DNA-damage that is accompanied by activation of p53 tumor suppressor, a key regulator of tumor development and…”
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Cancer cell injury by cytotoxins from cobra venom is mediated through lysosomal damage by Feofanov, Alexei V, Sharonov, George V, Astapova, Maria V, Rodionov, Dmitriy I, Utkin, Yuriy N, Arseniev, Alexander S

“…Cytotoxins from cobra venom are known to manifest cytotoxicity in various cell types. It is widely accepted that the plasma membrane is a target of cytotoxins,…”
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Analysis of GPI-Anchored Receptor Distribution and Dynamics in Live Cells by Tag-mediated Enzymatic Labeling and FRET by Balatskaya, Maria N, Baglay, Alexandra I, Rubtsov, Yury P, V Sharonov, Georgy

“…The analysis of glycosylphosphatidylinositol (GPI)-anchored receptor distribution and dynamics in live cells is challenging, because their clusters exhibit…”
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