Search Results - "Sharon Tran"

BECLIN1: Protein Structure, Function and Regulation by Tran, Sharon, Fairlie, W. Douglas, Lee, Erinna F.

“…BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian survival. It functions in conjunction with other proteins to form Class…”
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Real-time visualization of perforin nanopore assembly by Leung, Carl, Hodel, Adrian W., Brennan, Amelia J., Lukoyanova, Natalya, Tran, Sharon, House, Colin M., Kondos, Stephanie C., Whisstock, James C., Dunstone, Michelle A., Trapani, Joseph A., Voskoboinik, Ilia, Saibil, Helen R., Hoogenboom, Bart W.

“…Perforin is a key protein of the vertebrate immune system. Secreted by cytotoxic lymphocytes as soluble monomers, perforin can self-assemble into oligomeric…”
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In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions by Atkin-Smith, Georgia K., Santavanond, Jascinta P., Light, Amanda, Rimes, Joel S., Samson, Andre L., Er, Jeremy, Liu, Joy, Johnson, Darryl N., Le Page, Mélanie, Rajasekhar, Pradeep, Yip, Raymond K. H., Geoghegan, Niall D., Rogers, Kelly L., Chang, Catherine, Bryant, Vanessa L., Margetts, Mai, Keightley, M. Cristina, Kilpatrick, Trevor J., Binder, Michele D., Tran, Sharon, Lee, Erinna F., Fairlie, Walter D., Ozkocak, Dilara C., Wei, Andrew H., Hawkins, Edwin D., Poon, Ivan K. H.

“…Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly…”
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Bithionol blocks pathogenicity of bacterial toxins, ricin and Zika virus by Leonardi, William, Zilbermintz, Leeor, Cheng, Luisa W., Zozaya, Josue, Tran, Sharon H., Elliott, Jeffrey H., Polukhina, Kseniya, Manasherob, Robert, Li, Amy, Chi, Xiaoli, Gharaibeh, Dima, Kenny, Tara, Zamani, Rouzbeh, Soloveva, Veronica, Haddow, Andrew D., Nasar, Farooq, Bavari, Sina, Bassik, Michael C., Cohen, Stanley N., Levitin, Anastasia, Martchenko, Mikhail

“…Diverse pathogenic agents often utilize overlapping host networks and hub proteins within these networks represent attractive targets for broad-spectrum drugs…”
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Cross-inhibition of pathogenic agents and the host proteins they exploit by Zilbermintz, Leeor, Leonardi, William, Tran, Sharon H., Zozaya, Josue, Mathew-Joseph, Alyssa, Liem, Spencer, Levitin, Anastasia, Martchenko, Mikhail

“…The major limitations of pathogen-directed therapies are the emergence of drug-resistance and their narrow spectrum of coverage. A recently applied approach…”
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BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking by Tran, Sharon, Juliani, Juliani, Harris, Tiffany J., Evangelista, Marco, Ratcliffe, Julian, Ellis, Sarah L., Baloyan, David, Reehorst, Camilla M., Nightingale, Rebecca, Luk, Ian Y., Jenkins, Laura J., Ghilas, Sonia, Yakou, Marina H., Inguanti, Chantelle, Johnson, Chad, Buchert, Michael, Lee, James C., De Cruz, Peter, Duszyc, Kinga, Gleeson, Paul A., Kile, Benjamin T., Mielke, Lisa A., Yap, Alpha S., Mariadason, John M., Fairlie, W. Douglas, Lee, Erinna F.

“…Autophagy-related genes have been closely associated with intestinal homeostasis. BECLIN1 is a component of Class III phosphatidylinositol 3-kinase complexes…”
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Sherryl Vint, Biopolitical Futures in Twenty-First-Century Speculative Fiction by Tran, Sharon

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Biopolitical Futures in Twenty-First-Century Speculative Fiction by Sherryl Vint (review) by Tran, Sharon

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Kawaii Asian Girls Save the Day! Animating a Minor Politics of Care by Tran, Sharon

“…This essay explores the violence and viability of kawaii, a Japanese "cute" aesthetic, for theorizing Asian American feminism. Critics point out kawaii's…”
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Predictors of healthcare usage among Asian Americans during the COVID-19 pandemic in California by Tran, Sharon Kim, Santhiveeran, Janaki

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Crosstalk between apoptosis and autophagy signaling pathways by Fairlie, W Douglas, Tran, Sharon, Lee, Erinna F

“…The fate of a cell is determined by multiple signaling pathways in response to a range of stimuli. Probably the most prominent cell death mechanism is…”
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The emerging roles of autophagy in intestinal epithelial cells and its links to inflammatory bowel disease by Tran, Sharon, Juliani, Juliani, Fairlie, W Douglas, Lee, Erinna F

“…Landmark genome-wide association studies (GWAS) identified that mutations in autophagy genes correlated with inflammatory bowel disease (IBD), a heterogenous…”
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BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival by Lee, Erinna F., Harris, Tiffany J., Tran, Sharon, Evangelista, Marco, Arulananda, Surein, John, Thomas, Ramnac, Celeste, Hobbs, Chloe, Zhu, Haoran, Gunasingh, Gency, Segal, David, Behren, Andreas, Cebon, Jonathan, Dobrovic, Alexander, Mariadason, John M., Strasser, Andreas, Rohrbeck, Leona, Haass, Nikolas K., Herold, Marco J., Fairlie, W. Douglas

“…Malignant melanoma is one of the most difficult cancers to treat due to its resistance to chemotherapy. Despite recent successes with BRAF inhibitors and…”
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Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1 by Lee, Erinna F., Smith, Nicholas A., Soares da Costa, Tatiana P., Meftahi, Nastaran, Yao, Shenggen, Harris, Tiffany J., Tran, Sharon, Pettikiriarachchi, Anne, Perugini, Matthew A., Keizer, David W., Evangelista, Marco, Smith, Brian J., Fairlie, W. Douglas

“…BECN1/Beclin 1 is a critical protein in the initiation of autophagosome formation. Recent studies have shown that phosphorylation of BECN1 by STK4/MST1 at…”
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Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death by Jenkins, Laura J, Luk, Ian Y, Fairlie, W Douglas, Lee, Erinna F, Palmieri, Michelle, Schoffer, Kael L, Tan, Tao, Ng, Irvin, Vukelic, Natalia, Tran, Sharon, Tse, Janson W T, Nightingale, Rebecca, Alam, Zakia, Chionh, Fiona, Iatropoulos, George, Ernst, Matthias, Afshar-Sterle, Shoukat, Desai, Jayesh, Gibbs, Peter, Sieber, Oliver M, Dhillon, Amardeep S, Tebbutt, Niall C, Mariadason, John M

“…The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyperactivated in most colorectal cancers. A current limitation of inhibitors of this pathway is that they…”
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Abstract B014: Genotype-tailored ERK/MAPK pathway and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death by Jenkins, Laura J., Luk, Ian Y., Fairlie, Walter D., Lee, Erinna F., Palmieri, Michelle, Schoffer, Kael L., Tan, Tao, Ng, Irvin, Vukelic, Natalia, Tran, Sharon, Tse, Janson, Nightingale, Rebecca, Alam, Zakia, Chionh, Fiona, Iatropoulos, George, Ernst, Matthias, Afshar-Sterle, Shoukat, Desai, Jayesh, Gibbs, Peter, Sieber, Oliver M., Dhillon, Amardeep S., Tebbutt, Niall C., Mariadason, John M.

“…Abstract The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyper-activated in most colorectal cancers (CRCs). A current limitation of inhibitors of this…”
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Genetic and epigenetic changes associated with cholangiocarcinoma： From DNA methylation to microRNAs by Stutes, Monique, Tran, Steven, DeMorrow, Sharon

“…Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about the molecular development…”
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Between Asian Girls Minor Feminisms and Sideways Critique by Tran, Sharon N

“…This dissertation expands existing accounts of the history of Asian racialization in the United States by examining the various discursive, symbolic, and…”
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Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals by Elizabeth T. Montaño, Jason F. Nideffer, Lauren Brumage, Marcella Erb, Julia Busch, Lynley Fernandez, Alan I. Derman, John Paul Davis, Elena Estrada, Sharon Fu, Danielle Le, Aishwarya Vuppala, Cassidy Tran, Elaine Luterstein, Shivani Lakkaraju, Sriya Panchagnula, Caroline Ren, Jennifer Doan, Sharon Tran, Jamielyn Soriano, Yuya Fujita, Pranathi Gutala, Quinn Fujii, Minda Lee, Anthony Bui, Carleen Villarreal, Samuel R. Shing, Sean Kim, Danielle Freeman, Vipula Racha, Alicia Ho, Prianka Kumar, Kian Falah, Thomas Dawson, Eray Enustun, Amy Prichard, Ana Gomez, Kanika Khanna, Shelly Trigg, Kit Pogliano, Joe Pogliano

“…The threat to public health posed by drug-resistant bacteria is rapidly increasing, as some of healthcare’s most potent antibiotics are becoming obsolete…”
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Diversity in the intrinsic apoptosis pathway of nematodes by Young, Neil D., Harris, Tiffany J., Evangelista, Marco, Tran, Sharon, Wouters, Merridee A., Soares da Costa, Tatiana P., Kershaw, Nadia J., Gasser, Robin B., Smith, Brian J., Lee, Erinna F., Fairlie, W. Douglas

“…Early studies of the free-living nematode C. elegans informed us how BCL-2-regulated apoptosis in humans is regulated. However, subsequent studies showed C…”
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