Search Results - "Sharon, Ronit"

Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies by Kisos, Haya, Pukaß, Katharina, Ben-Hur, Tamir, Richter-Landsberg, Christiane, Sharon, Ronit

“…Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by striatonigral degeneration and olivo-pontocerebellar atrophy. The…”
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Loss of Corticostriatal Mu-Opioid Receptors in α-Synuclein Transgenic Mouse Brains by Grigoletto, Jessica, Schechter, Meir, Sharon, Ronit

“…Ultrastructural, neurochemical, and molecular alterations within the striatum are associated with the onset and progression of Parkinson's disease (PD). In PD,…”
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Alpha synuclein deficiency increases CD4+ T‐cells pro‐inflammatory profile in a Nurr1‐dependent manner by Trudler, Dorit, Levy‐Barazany, Hilit, Nash, Yuval, Samuel, Liron, Sharon, Ronit, Frenkel, Dan

“…It has been suggested that extracellular alpha synuclein (αSyn) can mediate neuroinflammation in Parkinson’s disease, and that αSyn affects B‐cell maturation…”
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α‐Synuclein in blood cells differentiates Parkinson’s disease from healthy controls by Abd Elhadi, Suaad, Grigoletto, Jessica, Poli, Maura, Arosio, Paolo, Arkadir, David, Sharon, Ronit

“…Objective To determine whether blood cells expressed α‐Syn can differentiate Parkinson’s disease (PD) from healthy controls (HC). Methods The concentrations of…”
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A role for α-Synuclein in axon growth and its implications in corticostriatal glutamatergic plasticity in Parkinson's disease by Schechter, Meir, Grigoletto, Jessica, Abd-Elhadi, Suaad, Glickstein, Hava, Friedman, Alexander, Serrano, Geidy E, Beach, Thomas G, Sharon, Ronit

“…α-Synuclein (α-Syn) is a protein implicated in the pathogenesis of Parkinson's disease (PD). α-Syn has been shown to associate with membranes and bind acidic…”
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Lysine residues at the first and second KTKEGV repeats mediate α-Synuclein binding to membrane phospholipids by Zarbiv, Yonaton, Simhi-Haham, Dganit, Israeli, Eitan, Elhadi, Suaad Abed, Grigoletto, Jessica, Sharon, Ronit

“…Abstract While α-Synuclein (α-Syn) is mainly detected as a cytosolic protein, a portion of it is recovered bound to membranes. It is suggested that binding to…”
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α-Synuclein Translocates to the Nucleus to Activate Retinoic-Acid-Dependent Gene Transcription by Davidi, Dana, Schechter, Meir, Elhadi, Suaad Abd, Matatov, Adar, Nathanson, Lubov, Sharon, Ronit

“…α-Synuclein (α-Syn) protein is implicated in the pathogenesis of Parkinson disease (PD). It is primarily cytosolic and interacts with cell membranes. α-Syn…”
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Human cytomegalovirus pUL37x1-induced calcium flux activates PKCα, inducing altered cell shape and accumulation of cytoplasmic vesicles by Sharon-Friling, Ronit, Shenk, Thomas

“…The human cytomegalovirus immediate-early protein pUL37x1 induces the release of Ca(2+) stores from the endoplasmic reticulum into the cytosol. This release…”
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Safety and Tolerability, Dose-Escalating, Double-Blind Trial of Oral Mannitol in Parkinson's Disease by Linetsky, Eduard, Abd Elhadi, Suaad, Bauer, Max, Gallant, Akiva, Namnah, Montaser, Weiss, Sagit, Segal, Daniel, Sharon, Ronit, Arkadir, David

“…Mannitol, a natural alcoholic-sugar, was recently suggested as a potential disease-modifying agent in Parkinson's disease. In animal models of the disease,…”
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Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss by Grigoletto, Jessica, Pukaß, Katharina, Gamliel, Ayelet, Davidi, Dana, Katz-Brull, Rachel, Richter-Landsberg, Christiane, Sharon, Ronit

“…α-Synuclein is a protein involved in the pathogenesis of synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple…”
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α-Synuclein Occurs in Lipid-Rich High Molecular Weight Complexes, Binds Fatty Acids, and Shows Homology to the Fatty Acid-Binding Proteins by Sharon, Ronit, Goldberg, Matthew S., Bar-Josef, Ifat, Betensky, Rebecca A., Shen, Jie, Selkoe, Dennis J.

“…α-Synuclein (αS) is a 140-residue neuronal protein that forms insoluble cytoplasmic aggregates in Parkinson's disease (PD) and several other neurodegenerative…”
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α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease by Israeli, Eitan, Yakunin, Eugenia, Zarbiv, Yonaton, Hacohen-Solovich, Amir, Kisos, Haya, Loeb, Virginie, Lichtenstein, Michal, Ben-Gedalya, Tziona, Sabag, Ofra, Pikarsky, Eli, Lorberboum-Galski, Haya, Sharon, Ronit

“…Alpha Synuclein (α-Syn) is a protein implicated in mechanisms of neuronal degeneration in Parkinson's disease (PD). α-Syn is primarily a neuronal protein,…”
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The regulation of catalase activity by PPAR γ is affected by α‐synuclein by Yakunin, Eugenia, Kisos, Haya, Kulik, Willem, Grigoletto, Jessica, Wanders, Ronald J. A., Sharon, Ronit

“…Objective While evidence for oxidative injury is frequently detected in brains of humans affected by Parkinson's disease (PD) and in relevant animal models,…”
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Human Cytomegalovirus pUL37x1 Induces the Release of Endoplasmic Reticulum Calcium Stores by Sharon-Friling, Ronit, Goodhouse, Joseph, Colberg-Poley, Anamaris M., Shenk, Thomas

“…The human CMV UL37x1-encoded protein, also known as the viral mitochondria-localized inhibitor of apoptosis, traffics to the endoplasmic reticulum and…”
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Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress by Liu, Sean T.H, Sharon-Friling, Ronit, Ivanova, Pavlina, Milne, Stephen B, Myers, David S, Rabinowitz, Joshua D, Brown, H. Alex, Shenk, Thomas

“…Human cytomegalovirus induces and requires fatty acid synthesis. This suggests an essential role for lipidome remodeling in viral replication. We used mass…”
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α-Synuclein facilitates endocytosis by elevating the steady-state levels of phosphatidylinositol 4,5-bisphosphate by Schechter, Meir, Atias, Merav, Abd Elhadi, Suaad, Davidi, Dana, Gitler, Daniel, Sharon, Ronit

“…α-Synuclein (α-Syn) is a protein implicated in the pathogenesis of Parkinson's disease (PD). It is an intrinsically disordered protein that binds acidic…”
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β-Synuclein occurs in vivo in lipid-associated oligomers and forms hetero-oligomers with α-synuclein by Israeli, Eitan, Sharon, Ronit

“…α-synuclein (αS) and β-synuclein (βS) are homologous proteins implicated in Parkinson's disease and related synucleinopathies. While αS is neurotoxic and its…”
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The Transgenic Overexpression of α-Synuclein and Not Its Related Pathology Associates with Complex I Inhibition by Loeb, Virginie, Yakunin, Eugenia, Saada, Ann, Sharon, Ronit

“…α-Synuclein (αS) is a protein involved in the cytopathology and genetics of Parkinson disease and is thought to affect mitochondrial complex I activity…”
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The Clathrin-Dependent Localization of Dopamine Transporter to Surface Membranes Is Affected by α-Synuclein by Kisos, Haya, Ben-Gedalya, Tziona, Sharon, Ronit

“…Parkinson's disease (PD) is a progressive age-dependent neurodegenerative disorder, predominantly affecting the dopamine-producing neurons residing at the…”
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Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA by Abd-Elhadi, Suaad, Basora, Misericordia, Vilas, Dolores, Tolosa, Eduardo, Sharon, Ronit

“…The validity of α-synuclein (α-Syn) as a biomarker for Parkinson’s disease (PD) is still under investigation. Conventional methods for capture and quantitation…”
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