Search Results - "Sharon, R."

HIV infection: epidemiology, pathogenesis, treatment, and prevention by Maartens, Gary, Prof, Celum, Connie, Prof, Lewin, Sharon R, Prof

“…Summary HIV prevalence is increasing worldwide because people on antiretroviral therapy are living longer, although new infections decreased from 3·3 million…”
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Genotype Imputation with Millions of Reference Samples by Browning, Brian L., Browning, Sharon R.

“…We present a genotype imputation method that scales to millions of reference samples. The imputation method, based on the Li and Stephens model and implemented…”
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Identification of families in need of support: Correlates of adverse childhood experiences in the right@home sustained nurse home visiting program by Kemp, Lynn, Bruce, Tracey, Elcombe, Emma L, Byrne, Fiona, Scharkie, Sheryl A, Perlen, Susan M, Goldfeld, Sharon R

“…Background Little is known about the efficacy of pregnancy screening tools using non-sensitive sociodemographic questions to identify the possible presence of…”
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The end of AIDS: HIV infection as a chronic disease by Deeks, Steven G, Prof, Lewin, Sharon R, Prof, Havlir, Diane V, Prof

“…Summary The success of antiretroviral therapy has led some people to now ask whether the end of AIDS is possible. For patients who are motivated to take…”
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A One-Penny Imputed Genome from Next-Generation Reference Panels by Browning, Brian L., Zhou, Ying, Browning, Sharon R.

“…Genotype imputation is commonly performed in genome-wide association studies because it greatly increases the number of markers that can be tested for…”
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Accurate Non-parametric Estimation of Recent Effective Population Size from Segments of Identity by Descent by Browning, Sharon R., Browning, Brian L.

“…Existing methods for estimating historical effective population size from genetic data have been unable to accurately estimate effective population size during…”
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Fast two-stage phasing of large-scale sequence data by Browning, Brian L., Tian, Xiaowen, Zhou, Ying, Browning, Sharon R.

“…Haplotype phasing is the estimation of haplotypes from genotype data. We present a fast, accurate, and memory-efficient haplotype phasing method that scales to…”
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Controlling Site Selectivity in Palladium-Catalyzed C–H Bond Functionalization by Neufeldt, Sharon R, Sanford, Melanie S

“…Effective methodology to functionalize C–H bonds requires overcoming the key challenge of differentiating among the multitude of C–H bonds that are present in…”
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Chronic Obstructive Pulmonary Disease by Labaki, Wassim W, Rosenberg, Sharon R

“…Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and progressive airflow obstruction. Tobacco smoking is the…”
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Immune checkpoint blockade in infectious diseases by Wykes, Michelle N., Lewin, Sharon R.

“…Key Points Immunosuppressive pathways or immune checkpoints refer to inhibitory receptors expressed on immune cells that are crucial for maintaining…”
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Improving the accuracy and efficiency of identity-by-descent detection in population data by Browning, Brian L, Browning, Sharon R

“…Segments of indentity-by-descent (IBD) detected from high-density genetic data are useful for many applications, including long-range phase determination,…”
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A groupwise association test for rare mutations using a weighted sum statistic by Madsen, Bo Eskerod, Browning, Sharon R

“…Resequencing is an emerging tool for identification of rare disease-associated mutations. Rare mutations are difficult to tag with SNP genotyping, as…”
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Getting the “Kill” into “Shock and Kill”: Strategies to Eliminate Latent HIV by Kim, Youry, Anderson, Jenny L., Lewin, Sharon R.

“…Despite the success of antiretroviral therapy (ART), there is currently no HIV cure and treatment is life long. HIV persists during ART due to long-lived and…”
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A Unified Approach to Genotype Imputation and Haplotype-Phase Inference for Large Data Sets of Trios and Unrelated Individuals by Browning, Brian L., Browning, Sharon R.

“…We present methods for imputing data for ungenotyped markers and for inferring haplotype phase in large data sets of unrelated individuals and parent-offspring…”
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Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture by Browning, Sharon R., Browning, Brian L., Zhou, Ying, Tucci, Serena, Akey, Joshua M.

“…Anatomically modern humans interbred with Neanderthals and with a related archaic population known as Denisovans. Genomes of several Neanderthals and one…”
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Rethinking Gamma-secretase Inhibitors for Treatment of Non-small-Cell Lung Cancer: Is Notch the Target? by Pine, Sharon R

“…Lung cancer is the leading cause of cancer-related deaths among men and women. γ-Secretase inhibitors, a class of small-molecule compounds that target the…”
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RNA-RNA Interactions Enable Specific Targeting of Noncoding RNAs to Nascent Pre-mRNAs and Chromatin Sites by Engreitz, Jesse M., Sirokman, Klara, McDonel, Patrick, Shishkin, Alexander A., Surka, Christine, Russell, Pamela, Grossman, Sharon R., Chow, Amy Y., Guttman, Mitchell, Lander, Eric S.

“…Intermolecular RNA-RNA interactions are used by many noncoding RNAs (ncRNAs) to achieve their diverse functions. To identify these contacts, we developed a…”
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Rapid and Accurate Haplotype Phasing and Missing-Data Inference for Whole-Genome Association Studies By Use of Localized Haplotype Clustering by Browning, Sharon R., Browning, Brian L.

“…Whole-genome association studies present many new statistical and computational challenges due to the large quantity of data obtained. One of these challenges…”
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Detecting Natural Selection in Genomic Data by Vitti, Joseph J, Grossman, Sharon R, Sabeti, Pardis C

“…The past fifty years have seen the development and application of numerous statistical methods to identify genomic regions that appear to be shaped by natural…”
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Detecting Identity by Descent and Estimating Genotype Error Rates in Sequence Data by Browning, Brian L., Browning, Sharon R.

“…Existing methods for identity by descent (IBD) segment detection were designed for SNP array data, not sequence data. Sequence data have a much higher density…”
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