Search Results - "Sharon, Ofer"

Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults by Van Damme, Pierre, Oosterhuis-Kafeja, Froukje, Van der Wielen, Marie, Almagor, Yotam, Sharon, Ofer, Levin, Yotam

“…Abstract Background Intradermal vaccine delivery has been shown to induce good immune responses with low vaccine doses. Technologies for drug-delivery which…”
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Longitudinal plasma proteomic profiling of patients with non-small cell lung cancer undergoing immune checkpoint blockade by Harel, Michal, Lahav, Coren, Jacob, Eyal, Dahan, Nili, Sela, Itamar, Elon, Yehonatan, Raveh Shoval, Shani, Yahalom, Galit, Kamer, Iris, Zer, Alona, Sharon, Ofer, Carbone, David P, Dicker, Adam P, Bar, Jair, Shaked, Yuval

“…BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized the cancer therapy landscape due to long-term benefits in patients with advanced metastatic…”
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300 Longitudinal plasma proteomic profiling of non-small cell lung cancer patients undergoing immune checkpoint blockade-based therapy by Harel, Michal, Lahav, Coren, Jacob, Eyal, Sela, Itamar, Elon, Yehonatan, Yahalom, Galit, Kamer, Iris, Sharon, Ofer, Shaked, Yuval, Dicker, Adam, Carbone, David, Bar, Jair

“…BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by shifting the focus from the tumor to the immune system of the host…”
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Natural products with taxol-like anti-tumor activity: Synthetic approaches to eleutherobin and dictyostatin by Gennari, Cesare, Castoldi, Damiano, Sharon, Ofer

“…Eleutherobin and dictyostatin are antimitotic compounds which exert their cytotoxic activity by a taxol-like mode of action, i.e., hypernucleating tubulin…”
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21 Plasma-based proteomic profiling as a tool for predicting response to immunotherapy in melanoma patients by Harel, Michal, Lahav, Coren, Jacob, Eyal, Issler, Eran, Bar, Haim, Dicker, Adam, Sharon, Ofer, Bacchiocchi, Antonietta, Halaban, Ruth, Sznol, Mario, Shaked, Yuval

“…BackgroundIn recent years, studies have indicated that in response to almost any type of anti-cancer therapy, the patient (the host) may generate…”
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A Formal Total Synthesis of Eleutherobin Using the Ring-Closing Metathesis (RCM) Reaction of a Densely Functionalized Diene as the Key Step: Investigation of the Unusual Kinetically Controlled RCM Stereochemistry by Castoldi, Damiano, Caggiano, Lorenzo, Panigada, Laura, Sharon, Ofer, Costa, Anna M., Gennari, Cesare

“…Asymmetric oxyallylation reactions and ring‐closing metathesis have been used to synthesize compound 3, a key advanced intermediate used in the total synthesis…”
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Comprehensive healthcare resource use among newly diagnosed congestive heart failure by Weitzman, Dahlia, Bash, Lori, O], [A.

“…Congestive heart failure (CHF) is among the most common causes of hospital admissions and readmissions in the Western world. However, the burden of ambulatory…”
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A proteomic biomarker discovery platform for predicting clinical benefit of immunotherapy in advanced melanoma by Shaked, Yuval, Harel, Michal, Issler, Eran, Fremder, Ella, Jacob, Eyal, Dahan, Nili, Bar, Haim, Halaban, Ruth, Sznol, Mario, Sharon, Ofer

“…Abstract only 10037 Background: Immune checkpoint inhibitor-based immunotherapies that target CTLA-4 and the PD-1/PD-L1 axis have revolutionized the treatment…”
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A randomized trial of immune checkpoint inhibitor plasma proteomic biomarker and chemotherapy risk model in advanced non-small cell lung cancer by Singhal, Surbhi, Schokrpur, Shiruyeh, Elon, Yehonatan, McGregor, Kimberly, Ofer, Sharon, Gandara, David, Riess, Jonathan

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Abstract LB-401: A proteomics-based biomarker discovery platform for predicting clinical response to immune checkpoint inhibitor therapy in non-small cell lung cancer by Harel, Michal, Khononov, Irena, Issler, Eran, Lahav, Coren, Fremder, Ella, Jacob, Eyal, Dahan, Nili, Raviv, Ziv, Shkedy, Avishag, Jacob, Reema, Dicker, Adam, Bar, Haim, Sharon, Ofer, Shaked, Yuval

“…Immune checkpoint inhibitors (ICIs) have changed the treatment paradigm for non-small cell lung cancer (NSCLC) due to their unprecedented rates of durable…”
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Integration of proteomic and clinical data for the prediction of response to immune checkpoint inhibitor therapy in non-small cell lung cancer by Shaked, Yuval, Harel, Michal, Lahav, Coren, Jacob, Eyal, Sela, Itamar, Yahalom, Galit, Elon, Yehonatan, Sharon, Ofer, Kamer, Iris, Bar, Haim, Dicker, Adam P., Bar, Jair, Katzenelson, Rivka, Wolf, Ido, Gottfried, Maya, Abu-Amana, Mahmud, Agbarya, Abed, Nechushtan, Hovav, Moskovitz, Mor Tal, Zer, Alona

“…Abstract only e21110 Background: Immune checkpoint inhibitor (ICI) therapy represents one of the most promising cancer treatments to date. However, despite…”
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Synthesis of the C15–C23 fragment of dictyostatin using a highly stereoselective Carreira alkynylation by Sharon, Ofer, Monti, Chiara, Gennari, Cesare

“…A straightforward synthesis of the C15–C23 fragment of dictyostatin has been achieved by a highly stereoselective Carreira alkynylation between alkyne 1 and…”
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Urinary albumin excretion with sitagliptin compared to sulfonylurea as add on to metformin in type 2 diabetes patients with albuminuria: A real-world evidence study by Goldshtein, Inbal, Karasik, Avraham, Melzer-Cohen, Cheli, Engel, Samuel S, Yu, Shengsheng, Sharon, Ofer, Brodovicz, Kimberly, Gadir, Noga, Katzeff, Harvey L, Radican, Larry, Chodick, Gabriel, Shalev, Varda, Tunceli, Kaan

“…Abstract Aim To compare the change in urinary albumin to creatinine ratio (UACR) in type 2 diabetes (T2DM) patients with albuminuria who initiate sitagliptin…”
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A highly stereoselective synthesis of the C10-C23 fragment of (-)-dictyostatin by Monti, Chiara, Sharon, Ofer, Gennari, Cesare

“…A highly stereoselective synthesis of the C10-C23 fragment of (-)-dictyostatin has been achieved using a Carreira alkynylation and a Marshall-Tamaru…”
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A Formal Total Synthesis of Eleutherobin Through an Unprecedented Kinetically Controlled Ring-Closing-Metathesis Reaction of a Densely Functionalized Diene by Castoldi, Damiano, Caggiano, Lorenzo, Panigada, Laura, Sharon, Ofer, Costa, Anna M., Gennari, Cesare

“…The key step in a formal total synthesis of eleutherobin was an unprecedented kinetically controlled RCM reaction of a densely functionalized diene 1 bearing…”
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Renal impairment among postmenopausal women with osteoporosis from a large health plan in Israel by Yu, Jingbo, Goldshtein, Inbal, Shalev, Varda, O], [A.

“…Summary Bisphosphonates are a first-line treatment for osteoporosis but require adequate renal function. We estimated the prevalence of renal impairment among…”
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Synthesis of novel, simplified, C-7 substituted eleutheside analogues with potent microtubule-stabilizing activity by Castoldi, Damiano, Caggiano, Lorenzo, Bayón, Pau, Costa, Anna M., Cappella, Paolo, Sharon, Ofer, Gennari, Cesare

“…The synthesis of a number of novel, simplified, C-7 substituted eleutheside analogues with potent tubulin-assembling and microtubule-stabilizing properties is…”
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Synthesis and photosensitized oxygenation of cyclopropylidenecyclobutenes by Sharon, Ofer, Frimer, Aryeh A

“…Cyclopropylidenecyclobutenes and -cyclobutanes were conveniently prepared using the Petasis titanocene approach. The cyclobutenes were unreactive to singlet…”
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Pemphigus and infections by Brenner, Sarah, Sasson, Aushrat, Sharon, Ofer

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Surprising exocyclic regioselectivity in electrophilic additions to alkylidenecyclobutenes by Pizem, Hillel, Sharon, Ofer, Frimer, Aryeh A.

“…The addition of peracid, bromine, TCNE and singlet oxygen to alkylidenecyclobutenes shows a strong regioselectivity—in some cases regiospecificity—for the…”
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