Search Results - "Sharon, A."

Autophagy pathway: Cellular and molecular mechanisms by Yu, Li, Chen, Yang, Tooze, Sharon A.

“…Macroautophagy/autophagy is an essential, conserved self-eating process that cells perform to allow degradation of intracellular components, including soluble…”
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Dyskeratosis congenita and telomere biology disorders by Savage, Sharon A

“…Numerous genetic discoveries and the advent of clinical telomere length testing have led to the recognition of a spectrum of telomere biology disorders (TBDs)…”
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Climate change and extreme events are changing the biology of Polar Regions by Robinson, Sharon A.

“…Polar landscapes and their unique biodiversity are threatened by climate change. Wild reindeer are cultural and ecological keystone species, traversing across…”
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The autophagosome: origins unknown, biogenesis complex by Lamb, Christopher A., Yoshimori, Tamotsu, Tooze, Sharon A.

“…Key Points Autophagy is an evolutionarily conserved lysosome-mediated degradation process that involves membrane-bound organelles called autophagosomes…”
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Investing in School Mental Health: Strategies to Wisely Spend Federal and State Funding by Hoover, Sharon A

“…In the context of the current youth mental health crisis, it is prudent to reconsider how resources are allocated to facilitate the delivery of effective and…”
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Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy by Gianferante, D. Matthew, Mirabello, Lisa, Savage, Sharon A.

“…Key Points Osteosarcoma treatment and outcomes have not changed substantially over the past 30 years Osteosarcoma is associated with growth and certain…”
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A molecular perspective of mammalian autophagosome biogenesis by Mercer, Thomas J., Gubas, Andrea, Tooze, Sharon A.

“…Autophagy is a highly conserved process and is essential for the maintenance of cellular homeostasis. Autophagy occurs at a basal level in all cells, but it…”
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The origin of the autophagosomal membrane by Tooze, Sharon A, Yoshimori, Tamotsu

“…Macroautophagy is initiated by the formation of the phagophore (also called the isolation membrane). This membrane can both selectively and non-selectively…”
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Occupational moral injury and mental health: systematic review and meta-analysis by Williamson, Victoria, Stevelink, Sharon A.M., Greenberg, Neil

“…Many people confront potentially morally injurious experiences (PMIEs) in the course of their work which can violate deeply held moral values or beliefs,…”
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Achieving diversity in study populations: The importance of community engagement by Brangman, Sharon A.

“…The majority of clinical trials currently and historically do not include older adults or non‐white participants. While more women are being recruited, their…”
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Beginning at the ends: telomeres and human disease [version 1; peer review: 4 approved] by Savage, Sharon A

“…Studies of rare and common illnesses have led to remarkable progress in the understanding of the role of telomeres (nucleoprotein complexes at chromosome ends…”
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Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes by Simonsen, Anne, Tooze, Sharon A

“…Autophagy or "self-eating" is a highly conserved pathway that enables cells to degrade pieces of themselves in autolysosomes to enable their survival in times…”
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Digesting the Expanding Mechanisms of Autophagy by Ktistakis, Nicholas T, Tooze, Sharon A

“…Autophagy is a catabolic ‘self-eating’ pathway that is emerging as a crucial integration point in cell physiology. With its own set of genes, the autophagy…”
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Telomere length and cancer risk: finding Goldilocks by Savage, Sharon A.

“…Telomeres are the nucleoprotein complex at chromosome ends essential in genomic stability. Baseline telomere length (TL) is determined by rare and common…”
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Emerging roles of ATG proteins and membrane lipids in autophagosome formation by Nishimura, Taki, Tooze, Sharon A.

“…Autophagosome biogenesis is a dynamic membrane event, which is executed by the sequential function of autophagy-related (ATG) proteins. Upon autophagy…”
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Who Should Have Multigene Germline Testing for Hereditary Cancer? by Savage, Sharon A

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Autophagosome formation—The role of ULK1 and Beclin1–PI3KC3 complexes in setting the stage by Wirth, Martina, Joachim, Justin, Tooze, Sharon A

“…Abstract Autophagy is a conserved and highly regulated degradative membrane trafficking pathway, maintaining energy homeostasis and protein synthesis during…”
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Cancer in the National Cancer Institute inherited bone marrow failure syndrome cohort after fifteen years of follow-up by Alter, Blanche P, Giri, Neelam, Savage, Sharon A, Rosenberg, Philip S

“…The National Cancer Institute Inherited Bone Marrow Failure Syndromes Cohort enrolls patients with the four major syndromes: Fanconi anemia, dyskeratosis…”
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Mesenchymal stem cells: key players in cancer progression by Ridge, Sarah M, Sullivan, Francis J, Glynn, Sharon A

“…Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu…”
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Telomere biology disorders gain a family member by Savage, Sharon A.

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