Search Results - "Sharma, Vijay S."

Intramuscular Cobinamide Sulfite in a Rabbit Model of Sublethal Cyanide Toxicity by Brenner, Matthew, MD, Kim, Jae G., PhD, Mahon, Sari B., PhD, Lee, Jangwoen, PhD, Kreuter, Kelly A., MS, Blackledge, William, MD, Mukai, David, BS, Patterson, Steve, PhD, Mohammad, Othman, MD, Sharma, Vijay S., PhD, Boss, Gerry R., MD

“…Study objective Exposure to cyanide in fires and industrial exposures and intentional cyanide poisoning by terrorists leading to mass casualties is an ongoing…”
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Cyanide Produced by Human Isolates of Pseudomonas aeruginosa Contributes to Lethality in Drosophila melanogaster by Broderick, Kate E., Chan, Adriano, Balasubramanian, Maheswari, Feala, Jake, Reed, Sharon L., Panda, Markandeswar, Sharma, Vijay S., Pilz, Renate B., Bigby, Timothy D., Boss, Gerry R.

“…Some Pseudomonas aeruginosa strains are cyanogenic, and cyanide may contribute to the bacterium's virulence. Using human isolates of P. aeruginosa, we have…”
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Nitric Oxide Scavenging by the Cobalamin Precursor Cobinamide by Broderick, Kate E., Singh, Veena, Zhuang, Shunhui, Kambo, Amanpreet, Chen, Jeffrey C., Sharma, Vijay S., Pilz, Renate B., Boss, Gerry R.

“…Nitric oxide (NO) is an important signaling molecule, and a number of NO synthesis inhibitors and scavengers have been developed to allow study of NO functions…”
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Analysis of melting of some metals using pressure dependence of the Grüneisen parameter in the Lindemann law by Ashwini, D., Sharma, Vijay S., Sunil, K.

“…In order to obtain the melting curves representing the relationship between melting temperature and pressure for a material with the help of Lindemann’s law,…”
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Kinetics of Nitric Oxide Dissociation from Five- and Six-Coordinate Nitrosyl Hemes and Heme Proteins, Including Soluble Guanylate Cyclase by Kharitonov, Vladimir G, Sharma, Vijay S, Magde, Douglas, Koesling, Doris

“…Kinetics of NO dissociation were characterized for three five-coordinate systems, heme−NO, HSA−heme−NO (human serum albumin), GC−NO (soluble guanylate…”
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Nitric Oxide Inhibits Mammalian Methylmalonyl-CoA Mutase by Kambo, Amanpreet, Sharma, Vijay S., Casteel, Darren E., Woods, Virgil L., Pilz, Renate B., Boss, Gerry R.

“…Methylmalonyl-CoA mutase is a key enzyme in intermediary metabolism, and children deficient in enzyme activity have severe metabolic acidosis. We found that…”
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Kinetics and Equilibria of Soluble Guanylate Cyclase Ligation by CO:  Effect of YC-1 by Kharitonov, Vladimir G, Sharma, Vijay S, Magde, Douglas, Koesling, Doris

“…Previous work has proved that the enzyme-soluble guanylate cyclase, GC, is activated several 100-fold by the combination of carbon monoxide plus a…”
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Role of the Interdomain Linker Probed by Kinetics of CO Ligation to an Endothelial Nitric Oxide Synthase Mutant Lacking the Calmodulin Binding Peptide (Residues 503−517 in Bovine) by Zemojtel, Tomasz, Scheele, Jurgen S, Martásek, Pavel, Masters, Bettie Sue Siler, Sharma, Vijay S, Magde, Douglas

“…Oxygenase and reductase domains in nitric oxide synthase are linked by a peptide region that binds calmodulin. Here we study the effects of modifying the…”
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Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring by Brenner, Matthew, Mahon, Sari B, Lee, Jangwoen, Kim, Jae Gwan, Mukai, David S, Goodman, Seth, Kreuter, Kelly A, Ahdout, Rebecca, Mohammad, Othman, Sharma, Vijay S, Blackledge, William, Boss, Gerry R

“…Our purpose is to compare cobinamide to hydroxocobalamin in reversing cyanide (CN)-induced physiologic effects in an animal model using diffuse optical…”
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Reactions of Nitric Oxide with Vitamin B12 and Its Precursor, Cobinamide by Sharma, Vijay S, Pilz, Renate B, Boss, Gerry R, Magde, Douglas

“…Despite early claims that nitric oxide does not react with cobalamin under any circumstances, it is now accepted that NO has a high affinity for cobalamin in…”
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Cyanide detoxification by the cobalamin precursor cobinamide by Broderick, Kate E, Potluri, Prasanth, Zhuang, Shunhui, Scheffler, Immo E, Sharma, Vijay S, Pilz, Renate B, Boss, Gerry R

“…Cyanide is a highly toxic agent that inhibits mitochondrial cytochrome-c oxidase, thereby depleting cellular ATP. It contributes to smoke inhalation deaths in…”
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Kinetics of Nitrosation of Thiols by Nitric Oxide in the Presence of Oxygen by Kharitonov, V G, Sundquist, A R, Sharma, V S

“…Nitrosothiols are powerful vasodilators. They act by releasing nitric oxide, which activates the heme protein guanylate cyclase. We have studied the kinetics…”
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Why nitric oxide? by Traylor, Teddy G, Sharma, Vijay S

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Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo by Broderick, Kate E, Alvarez, Luis, Balasubramanian, Mahesh, Belke, Darrell D, Makino, Ayako, Chan, Adriano, Woods, Jr, Virgil L, Dillmann, Wolfgang H, Sharma, Vijay S, Pilz, Renate B, Bigby, Timothy D, Boss, Gerry R

“…A limited number of nitric oxide (NO)-generating drugs are available for clinical use for acute and chronic conditions. Most of these agents are organic…”
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The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide by Broderick, Kate E, Balasubramanian, Maheswari, Chan, Adriano, Potluri, Prasanth, Feala, Jake, Belke, Darrell D, McCulloch, Andrew, Sharma, Vijay S, Pilz, Renate B, Bigby, Timothy D, Boss, Gerry R

“…Sodium nitroprusside is used to treat hypertensive emergencies and acute heart failure. It acts by releasing nitric oxide (NO), a highly potent vasodilator,…”
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Activation of Soluble Guanylate Cyclase by Carbon Monoxide and Nitric Oxide: A Mechanistic Model by Sharma, Vijay S., Magde, Douglas

“…Soluble guanylate cyclase (GC) from bovine lung is activated 4-fold by carbon monoxide (CO) and 400-fold by nitric oxide (NO). Spectroscopic and kinetic data…”
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Nitric Oxide Inhibits Methionine Synthase Activity in Vivo and Disrupts Carbon Flow through the Folate Pathway by Danishpajooh, Idrees O., Gudi, Tanima, Chen, Yongchang, Kharitonov, Vladimir G., Sharma, Vijay S., Boss, Gerry R.

“…Many of nitric oxide's biological effects are mediated via NO binding to the iron in heme-containing proteins. Cobalamin (vitamin B12) is structurally similar…”
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The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis by Broderick, Kate E., Feala, Jake, McCulloch, Andrew, Paternostro, Giovanni, Sharma, Vijay S., Pilz, Renate B., Boss, Gerry R.

“…Septic shock has an extremely high mortality rate, with ∼200,000 people dying from sepsis annually in the U.S. The high mortality results in part from severe…”
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Basis of Guanylate Cyclase Activation by Carbon Monoxide by Kharitonov, Vladimir G., Sharma, Vijay S., Pilz, Renate B., Magde, Douglas, Koesling, Doris

“…Kinetics of CO association with guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] and dissociation from carboxy guanylate cyclase have been…”
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Melting curves of diatomic solids using the Lindemann law and a density-dependent Grüneisen parameter by K, Anand, K, Rajesh, Sharma, Vijay S.

“…In this work we used the Lindemann law of melting assuming a density dependence of the Grüneisen parameter (based on the Roy-Sarkar model) to obtain melting…”
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