Predictive Value of C-reactive Protein in the Spontaneous Passage of Lower Ureteric Stones: A Prospective Single-Centre Study

Predictive Value of C-reactive Protein in the Spontaneous Passage of Lower Ureteric Stones: A Prospective Single-Centre Study

Ureteric stones, characterised by their presence in the ureter, present a common yet often painful urological condition requiring timely intervention. As C-reactive protein (CRP) emerges as a potential biomarker, its correlation with the spontaneous stone passage (SSP) offers valuable insights into...

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Published in:Curēus (Palo Alto, CA) Vol. 16; no. 6; p. e62669
Main Authors: Ahmad, Ahsan, Mahmood, Khalid, Kumar, Nandesh, Sharma, Ravi R, Ranjan, Nikhil, Anand, Rakesh Kumar, Kumar, Shishir
Format: Journal Article
Language:English
Published: United States Cureus Inc 19-06-2024
Subjects:
Biomarkers
Blood tests
Body mass index
Calcium phosphates
Density
Gandhi, Indira (1917-1984)
Hematuria
Inflammation
Leukocytes
Lithotripsy
Neutrophils
Patients
Proteins
Statistical analysis
Uric acid
Urinary tract diseases
Urinary tract infections
Urogenital system
India
ureteric stone
biomarker
leukocyturia
c –reactive protein (crp)
neutrophil levels
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Summary:Ureteric stones, characterised by their presence in the ureter, present a common yet often painful urological condition requiring timely intervention. As C-reactive protein (CRP) emerges as a potential biomarker, its correlation with the spontaneous stone passage (SSP) offers valuable insights into patient management and treatment strategies. The present study aimed to assess if CRP levels can predict SSP in symptomatic lower ureteric calculi of size 5 mm-10 mm. This prospective observational study, conducted at the Indira Gandhi Institute of Medical Sciences in Patna, India, from July 2022 to June 2023, focused on individuals aged 13 to 60 years presenting with ureteric colic and single distal ureteral stones (5 mm-10 mm). Patients underwent comprehensive initial assessment and monitoring, including diagnostic procedures such as a complete blood count, urinalysis, CRP levels, and renal function evaluations. Treatment consisted of hydration encouragement, tamsulosin (0.4 mg) daily administration, and diclofenac (50 mg) as needed. Follow-up assessments at one-month post-treatment involved clinical examination and imaging studies to evaluate treatment efficacy. This study analysed 157 patients with ureteric stones, finding that 76% experienced SSP. Lower CRP levels (≤6 mg/L), along with other laboratory parameters like low white blood cell counts, low neutrophil levels, absence of leukocyturia, absence of hematuria, and lower urine specific gravity, were associated with higher SSP rates. C-reactive protein levels ≤6 mg/L emerged as a strong predictor of SSP in multiple regression analysis. The findings underscore the potential utility of CRP as a predictive biomarker in guiding the management and treatment strategies for ureteric stones.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.62669