Search Results - "Sharma, Monal"

Circulating Exosomes with Distinct Properties during Chronic Lung Allograft Rejection by Gunasekaran, Muthukumar, Sharma, Monal, Hachem, Ramsey, Bremner, Ross, Smith, Michael A, Mohanakumar, Thalachallour

“…Circulating exosomes containing donor HLA and lung-associated self-antigens (SAg) are thought to play an important role in allograft rejection after human lung…”
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Exosomes expressing the self‐antigens myosin and vimentin play an important role in syngeneic cardiac transplant rejection induced by antibodies to cardiac myosin by Sharma, Monal, Liu, Wei, Perincheri, Sudhir, Gunasekaran, Muthukumar, Mohanakumar, T.

“…Long‐term success of heart transplantation is hindered by humoral and cell‐mediated immune responses. We studied preexisting antibodies to cardiac…”
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Alternating exosomes and their mimetics as an emergent strategy for targeted cancer therapy by Mishra, Lokesh Chandra, Pandey, Utkarsh, Gupta, Abhikarsh, Gupta, Jyotsna, Sharma, Monal, Mishra, Gauri

“…Exosomes, a subtype of the class of extracellular vesicles and nano-sized particles, have a specific membrane structure that makes them an alternative…”
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Cardiac antibody production to self-antigens in children and adolescents during and following the correction of severe diabetic ketoacidosis by Hoffman, William H., Sharma, Monal, Cihakova, Daniela, Talor, Monica V., Rose, Noel R., Mohanakumar, T., Passmore, Gregory G.

“…Diabetic cardiomyopathy (DC) is an independent phenotype of diabetic cardiovascular disease. The understanding of the pathogenesis of DC in young patients with…”
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Research Highlights by Sharma, Monal, Luo, Xunrong

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Research Highlights by Sharma, Monal, Luo, Xunrong

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Respiratory viral infection in lung transplantation induces exosomes that trigger chronic rejection by Gunasekaran, Muthukumar, Bansal, Sandhya, Ravichandran, Ranjithkumar, Sharma, Monal, Perincheri, Sudhir, Rodriguez, Francisco, Hachem, Ramsey, Fisher, Cynthia E., Limaye, Ajit P., Omar, Ashraf, Smith, Michael A., Bremner, Ross M., Mohanakumar, Thalachallour

“…Respiratory viral infections can increase the risk of chronic lung allograft dysfunction after lung transplantation, but the mechanisms are unknown. In this…”
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The role of exosomes in allograft immunity by Bansal, Sandhya, Sharma, Monal, R, Ranjithkumar, Mohanakumar, T.

“…•Different types of extracellular vesicles, their composition.•Role for exosomes in allograft immunity.•Exosomes with tissue associated self-antigens as…”
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Prevalence of antibodies to lung self-antigens (Kα1 tubulin and collagen V) and donor specific antibodies to HLA in lung transplant recipients and implications for lung transplant outcomes: Single center experience by Rao, Usha, Sharma, Monal, Mohanakumar, Thalachallour, Ahn, Chul, Gao, Ang, Kaza, Vaidehi

“…For patients with end stage lung disease, lung transplantation (LT) remains the only definitive treatment option. Long term survival post LT is limited by…”
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Significant role for microRNA-21 affecting toll-like receptor pathway in primary graft dysfunction after human lung transplantation by Xu, Zhongping, Sharma, Monal, Gelman, Andrew, Hachem, Ramsey, Mohanakumar, T

“…Background MicroRNAs (miRNAs) were recently identified as modulators of immune responses after human lung transplantation (LTx). This study was undertaken to…”
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Tissue-associated self-antigens containing exosomes: Role in allograft rejection by Sharma, Monal, Ravichandran, Ranjithkumar, Bansal, Sandhya, Bremner, Ross M., Smith, Michael A., Mohanakumar, T.

“…Exosomes are extracellular vesicles that express self-antigens (SAgs) and donor human leukocyte antigens. Tissue-specific exosomes can be detected in the…”
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The role of donor-derived exosomes in lung allograft rejection by Ravichandran, Ranjithkumar, Bansal, Sandhya, Rahman, Mohammad, Sharma, Monal, Liu, Wei, Bharat, Ankit, Hachem, Ramsey, Omar, Ashraf, Smith, Michael A., Mohanakumar, T.

“…Lung transplant recipients (LTxRs) with acute or chronic rejection release circulating exosomes that mostly originate from donor lung tissue and express…”
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Circulating exosomes with lung self-antigens as a biomarker for chronic lung allograft dysfunction: A retrospective analysis by Sharma, Monal, Gunasekaran, Muthukumar, Ravichandran, Ranjithkumar, Fisher, Cynthia E., Limaye, Ajit P., Hu, Chengcheng, McDyer, John, Kaza, Vaidehi, Bharat, Ankit, Tokman, Sofya, Omar, Ashraf, Arjuna, Ashwini, Walia, Rajat, Bremner, Ross M., Smith, Michael A., Hachem, Ramsey R., Mohanakumar, Thalachallour

“…Exosomes isolated from plasma of lung transplant recipients (LTxRs) with bronchiolitis obliterans syndrome (BOS) contain human leukocyte antigens and lung…”
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OR47 A novel role for antibodies to HLA and self-antigens: Induction of immuno-stimulatory exosomes by Mohanakumar, Thalachallour, Gunasekaran, Muthukumar, Sharma, Monal, Bansal, Sandhya

“…Recent report from us demonstrated that lung transplant recipients who developed donor specific antibodies (DSA) against HLA and chronic rejection…”
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Identification of extracellular vesicle proteins in circulating exosomes from human lung transplant recipients by Bansal, Sandhya, Pirrotte, Patrick, McGilvrey, Marissa, Garcia-Mansfield, Krystine, Sharma, Monal, Gunasekaran, Muthukumar, Smith, Michael, Bremner, Ross, Mohanakumar, Thalachallour

“…Molecular mechanisms involved in rejection following human lung transplantation (LTx) are not well understood. We identified proteomic signatures of clinical…”
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Molecular events contributing to successful pediatric cardiac transplantation in HLA sensitized recipients by Sharma, Monal, Webber, S.A., Zeevi, A., Mohanakumar, T.

“…Antibodies to HLA resulting in positive cytotoxicity crossmatch are generally considered a contraindication for cardiac transplantation. However, cardiac…”
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Research Highlights by Sharma, Monal, Luo, Xunrong

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Differential expression of Homeobox C11 protein in water buffalo Bubalus bubalis and its putative 3D structure by Sharma, Monal, Rawal, Leena, Panwar, Deepak, Sehgal, Neeta, Ali, Sher

“…The Homeobox (Hox) family complex contains 39 genes, clustered into four groups (A-D) all expressing in sequential manner. The HOX proteins are transcriptional…”
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Gallic acid loaded disulfide cross-linked biocompatible polymeric nanogels as controlled release system: synthesis, characterization, and antioxidant activity by Behl, Gautam, Sharma, Monal, Sikka, Manisha, Dahiya, Saurabh, Chhikara, Aruna, Chopra, Madhu

“…In this article, a sustained release formulation of the antioxidant gallic acid (GA) is presented in the form of glutathione responsive disulfide cross-linked…”
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OR16 Antibodies to donor human leukocyte antigen induce exosomes containing tissue-restricted self-antigens in acute and chronic rejection by Gunasekaran, Muthukumar, Sharma, Monal, Hachem, Ramsey, Walia, Rajat, Shenoy, Surendra, Smith, Michael, Bremner, Ross, Mohanakumar, Thalachallour

“…Aim Immune responses to tissue-restricted self-antigens (SAgs) are known contributors to acute and chronic rejection in solid organ transplantation (Tx). The…”
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