Search Results - "Sharma, Maryada"

Induction of posterior vitreous detachment (PVD) by non-enzymatic reagents targeting vitreous collagen liquefaction as well as vitreoretinal adhesion by Santra, Mithun, Sharma, Maryada, Katoch, Deeksha, Jain, Sahil, Saikia, Uma Nahar, Dogra, Mangat R., Luthra-Guptasarma, Manni

“…Induction of posterior vitreous detachment (PVD) by pharmacologic vitreolysis has been largely attempted through the use of enzymatic reagents. Ocriplasmin has…”
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Genotyping Indian patients with primary cardiomyopathies-analysis of database by Vaidya, Vanya, Dhiman, Ramandeep Singh, Mittal, Anupam, Khullar, Madhu, Sharma, Maryada, Bahl, Ajay

“…Each population has its own unique genotype. Genotyping data on Indian cardiomyopathy patients is lacking. We aimed to create and analyse a database of…”
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Author Correction: Induction of posterior vitreous detachment (PVD) by non-enzymatic reagents targeting vitreous collagen liquefaction as well as vitreoretinal adhesion by Santra, Mithun, Sharma, Maryada, Katoch, Deeksha, Jain, Sahil, Saikia, Uma Nahar, Dogra, Mangat R., Luthra-Guptasarma, Manni

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Neutrophil NETworking in ENL: Potential as a Putative Biomarker: Future Insights by Sahu, Smrity, Sharma, Keshav, Sharma, Maryada, Narang, Tarun, Dogra, Sunil, Minz, Ranjana Walker, Chhabra, Seema

“…Erythema nodosum leprosum (ENL), also known as type 2 reaction (T2R) is an immune complex mediated (type III hypersensitivity) reactional state encountered in…”
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Fibrotic remodeling of the extracellular matrix through a novel (engineered, dual-function) antibody reactive to a cryptic epitope on the N-terminal 30 kDa fragment of fibronectin by Sharma, Maryada, Tiwari, Anil, Sharma, Shweta, Bhoria, Preeti, Gupta, Vishali, Gupta, Amod, Luthra-Guptasarma, Manni

“…Fibrosis is characterized by excessive accumulation of scar tissue as a result of exaggerated deposition of extracellular matrix (ECM), leading to tissue…”
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Amelioration of collagen antibody induced arthritis in mice by an antibody directed against the fibronectin type III repeats of tenascin-C by Mehta, Brij Bhushan, Tiwari, Anil, Sharma, Saniya, Shukla, Ashu, Sharma, Maryada, Vasishta, Rakesh K., Sen, Ramesh K., Sharma, Aman, Luthra-Guptasarma, Manni

“…Tenascin-C (TN-C) levels are elevated in the synovial tissue and fluid, as well as cartilage of rheumatoid arthritis (RA) patients. In addition, the presence…”
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Studies on Vibrio mimicus derived collagenase variants providing insights into critical role(s) played by the FAXWXXT motifs in its collagen-binding domain by Santra, Mithun, Sharma, Maryada, Luthra-Guptasarma, Manni

“…•Vibrio mimicus collagenase (VMC) acts similar to Clostridium collagenase (CC).•Poor sequence similarity between VMC and CC.•VMC has two collagen binding…”
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A single chain variable fragment antibody (Tn 64) cognate to fibronectin type III repeats promotes corneal wound healing by inhibiting fibrosis by Shukla, Ashu, Suresh, Vyshak, Gupta, Parul Chawla, Sharma, Maryada, Saikia, Uma Nahar, Ram, Jagat, Luthra-Guptasarma, Manni

“…[Display omitted] •scFv Tn64 effectively binds to 3–5 region of Tn C fibronectin type III repeats.•Tn fn 3–5 has a pro-fibrotic influence on corneal…”
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Neuro-Vascularized Skin Organoids: Novel Exploratory Research Tools in Leprosy by Sharma, Keshav, Chhabra, Seema, Sharma, Maryada

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Cutaneous‐immuno‐neuro‐endocrine (CINE) system: A complex enterprise transforming skin into a super organ by Shastri, Malvika, Sharma, Maryada, Sharma, Keshav, Sharma, Ayush, Minz, Ranjana Walker, Dogra, Sunil, Chhabra, Seema

“…Skin is now emerging as a complex realm of three chief systems viz. immune system, nervous system, and endocrine system. The cells involved in their intricate…”
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Expression of Proteinase-activated Receptor 2 (PAR2) as a Correlate of Concern in Triple-negative Breast Cancer (TNBC) by Kapatia, Gargi, Kaur, Subhpreet, Kumar, Sandeep, Laroiya, Ishita, Singh, Gurpreet, Sharma, Maryada, Bal, Amanjit, Luthra-Guptasarma, Manni

“…PURPOSETriple-negative breast cancer (TNBC), a highly aggressive cancer with poor outcome and lacking specific diagnostic, prognostic, or targeted therapeutic…”
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Cut-off points to classify numeric values of quality of life into normal, mild, moderate, and severe categories: an update for EORTC-QLQ-H N35 by Jyoti Saini, Jaimanti Bakshi, Naresh K. Panda, Maryada Sharma, Dharam Vir, Atul Kumar Goyal

“…Abstract Background Quality of life (QoL) is an important determinant of physical and mental health. QoL in head and neck cancer tends to deteriorate due to…”
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Degradation of proteins upon storage at near-neutral pH: Indications of a proteolytic/gelatinolytic activity associated with aggregates by Sharma, Maryada, Luthra-Guptasarma, Manni

“…The twin phenomena of aggregation and degradation are classically associated with protein storage. However, although aggregation has been thought to be a…”
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Control of fibrotic changes through the synergistic effects of anti-fibronectin antibody and an RGDS-tagged form of the same antibody by Tiwari, Anil, Kumar, Rajendra, Ram, Jagat, Sharma, Maryada, Luthra-Guptasarma, Manni

“…TGF-β and myofibroblasts play a key role in fibrosis, characterized by aberrant synthesis and deposition of extracellular matrix (ECM) proteins, such as…”
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Enzymatic vitreolysis using reengineered Vibrio mimicus- derived collagenase by Santra, Mithun, Sharma, Maryada, Katoch, Deeksha, Jain, Sahil, Saikia, Uma Nahar, Dogra, Mangat R, Luthra-Guptasarma, Manni

“…Collagen is a key player contributing to vitreoelasticity and vitreoretinal adhesions. Molecular reorganization causes spontaneous weakening of these adhesions…”
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Diagnostic and Prognostic Accuracy of MMPs and TIMPs in Oral Cancer Patients on Enzyme-Linked Immunosorbent Assay (ELISA) as Compared to Immunohistochemistry (IHC) by Saini, Jyoti, Bakshi, Jaimanti, Panda, Naresh Kumar, Sharma, Maryada, Yadav, Ashok Kumar, Narayansami, Suruthy, Goyal, Atul Kumar

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Use of discarded corneo-scleral rims to create cornea-like tissue by Sharma, Maryada, Kaur, Subhpreet, Mavlankar, Nimisha A., Chanda, Alokananda, Gupta, Parul Chawla, Saikia, Uma Nahar, Ram, Jagat, Pal, Asish, Mandal, Sanjay, Guptasarma, Purnananda, Luthra-Guptasarma, Manni

“…Background Corneal disease is a major cause of blindness. Transplantation of cadaver-derived corneas (keratoplasty) is still the current therapy of choice;…”
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Cut-off points to classify numeric values of quality of life into normal, mild, moderate, and severe categories: an update for EORTC-QLQ-H&N35 by Saini, Jyoti, Bakshi, Jaimanti, Panda, Naresh K., Sharma, Maryada, Vir, Dharam, Goyal, Atul Kumar

“…Background Quality of life (QoL) is an important determinant of physical and mental health. QoL in head and neck cancer tends to deteriorate due to changes in…”
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Serum Concentration of MMP-9 as a Predictive Biomarker for the Progression of Oral Cancer by Saini, Jyoti, Bakshi, Jaimanti, Panda, Naresh K., Sharma, Maryada, Yadav, Ashok K., Kamboj, Kajal, Goyal, Atul Kumar

“…Background Oral cancer is the most prominent cancer subtype among all head and neck cancers, the incidence and prevalence of which has been consistently…”
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A simulacrum of proliferative vitreoretinopathy (PVR): development and proteomics-based validation of an in vitro model by Sharma, Sumit, Thakur, Amit Kumar, Sharma, Maryada, Katoch, Deeksha, Bansal, Reema, Singh, Ramandeep, Dogra, Mangat R., Luthra-Guptasarma, Manni

“…The epithelial–mesenchymal transition (EMT) is a common feature of disease progression in diseases such as cancer and fibrosis. It is associated with the…”
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