Recent advances in breast cancer cell line research

Recent advances in breast cancer cell line research

Breast cancer, a formidable global health challenge, needs continuous translational research to understand the complexity of mechanisms and improve therapeutic and diagnostic strategies. Breast cancer cell lines are of paramount importance as they significantly contribute to the initial stage of res...

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Bibliographic Details
Published in:International journal of cancer Vol. 154; no. 10; pp. 1683 - 1693
Main Authors: Sharma, Manika P, Shukla, Supriya, Misra, Gauri
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 15-05-2024
Subjects:
Breast cancer
Cancer research
Cell culture
Global health
Immunotherapy
Medical diagnosis
Medical treatment
Microbiomes
Organoids
Public health
Translation
Tumor cell lines
Tumor cells
Tumor microenvironment
Tumors
Xenografts
cell line development
breast cancer
therapeutics
cell cultures
xenografts
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Summary:Breast cancer, a formidable global health challenge, needs continuous translational research to understand the complexity of mechanisms and improve therapeutic and diagnostic strategies. Breast cancer cell lines are of paramount importance as they significantly contribute to the initial stage of research to understand cancer biology. This review provides insights into targeted therapies and immunotherapies that have emerged using in vitro models and microbiome analysis. It focuses on therapeutic development using cell lines and the limitations of tumor heterogeneity and microenvironment. We explore the evolving landscape of breast cancer cell lines from two-dimensional (2-D) cultures to patient-derived xenograft (PDX) models advancing both fundamental and translational research. Patient-derived xenografts, cell line-derived xenografts (CDX), three-dimensional (3-D) cultures, organoids, and circulating tumor cells (CTC) models provide promising alternatives that capture the intricacies of the tumor microenvironment. This review bridges the gap between traditional cell lines and newer developments exploring the therapeutic and diagnostic advancements and needs for cell lines to expedite the progress in breast cancer research and treatment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.34849