Search Results - "Sharma, Jehoshua"

A CRISPR Interference Platform for Efficient Genetic Repression in Candida albicans by Wensing, Lauren, Sharma, Jehoshua, Uthayakumar, Deeva, Proteau, Yannic, Chavez, Alejandro, Shapiro, Rebecca S

“…Fungal pathogens are emerging as an important cause of human disease, and is among the most common causative agents of fungal infections. Studying this fungal…”
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Linking Cellular Morphogenesis with Antifungal Treatment and Susceptibility in Candida Pathogens by Sharma, Jehoshua, Rosiana, Sierra, Razzaq, Iqra, Shapiro, Rebecca S

“…Fungal infections are a growing public health concern, and an increasingly important cause of human mortality, with species being amongst the most frequently…”
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CRISPR-Based Genetic Manipulation of Candida Species: Historical Perspectives and Current Approaches by Uthayakumar, Deeva, Sharma, Jehoshua, Wensing, Lauren, Shapiro, Rebecca S.

“…The Candida genus encompasses a diverse group of ascomycete fungi that have captured the attention of the scientific community, due to both their role in…”
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Development and applications of a CRISPR activation system for facile genetic overexpression in Candida albicans by Gervais, Nicholas C, La Bella, Alyssa A, Wensing, Lauren F, Sharma, Jehoshua, Acquaviva, Victoria, Best, Madison, Cadena López, Ricardo Omar, Fogal, Meea, Uthayakumar, Deeva, Chavez, Alejandro, Santiago-Tirado, Felipe, Flores-Mireles, Ana L, Shapiro, Rebecca S

“…Abstract For the fungal pathogen Candida albicans, genetic overexpression readily occurs via a diversity of genomic alterations, such as aneuploidy and…”
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Superior Conjugative Plasmids Delivered by Bacteria to Diverse Fungi by Cochrane, Ryan R., Shrestha, Arina, Severo de Almeida, Mariana M., Agyare-Tabbi, Michelle, Brumwell, Stephanie L., Hamadache, Samir, Meaney, Jordyn S., Nucifora, Daniel P., Say, Henry Heng, Sharma, Jehoshua, Soltysiak, Maximillian P. M., Tong, Cheryl, Van Belois, Katherine, Walker, Emma J. L., Lachance, Marc-André, Gloor, Gregory B., Edgell, David R., Shapiro, Rebecca S., Karas, Bogumil J.

“…Fungi are nature’s recyclers, allowing for ecological nutrient cycling and, in turn, the continuation of life on Earth. Some fungi inhabit the human microbiome…”
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Mucin modulates microbial morphogenesis by Sharma, Jehoshua, Shapiro, Rebecca S.

“…The rising threat of antifungal resistance means that alternative therapeutics need to be considered. New research explores the biochemical basis of virulence…”
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A novel CRISPRi platform to study the role of essential genes in antifungal drug-resistant Candida albicans isolates by Wensing, Lauren, Shapiro, Rebecca, Uthayakumar, Deeva, Halder, Viola, Sharma, Jehoshua, Proteau, Yannic, Chavez, Alejandro

“…With the emergence of antifungal resistant Candida albicans strains, the need for new antifungal drugs is critical in combating this fungal pathogen…”
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Most azole resistance mutations in the Candida albicans drug target confer cross-resistance without intrinsic fitness cost by Bédard, Camille, Gagnon-Arsenault, Isabelle, Boisvert, Jonathan, Plante, Samuel, Dubé, Alexandre K., Pageau, Alicia, Fijarczyk, Anna, Sharma, Jehoshua, Maroc, Laetitia, Shapiro, Rebecca S., Landry, Christian R.

“…Azole antifungals are the main drugs used to treat fungal infections. Amino acid substitutions in the drug target Erg11 (Cyp51) are a common resistance…”
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A CRISPR Interference Platform for Efficient Genetic Repression in italic toggle="yes">Candida albicans /italic by Lauren Wensing, Jehoshua Sharma, Deeva Uthayakumar, Yannic Proteau, Alejandro Chavez, Rebecca S. Shapiro

“…ABSTRACT Fungal pathogens are emerging as an important cause of human disease, and Candida albicans is among the most common causative agents of fungal…”
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