Elevated serum PAR‐1 levels as an emerging biomarker of inflammation to predict the dengue infection severity

Elevated serum PAR‐1 levels as an emerging biomarker of inflammation to predict the dengue infection severity

The present study was designed to check the serum levels of protease‐activated receptor (PAR‐1) in patients during different phases of dengue severity. Moreover, a correlation between serum PAR‐1 levels and hematological parameters, inflammatory cytokine levels, and liver functional changes was also...

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Published in:Journal of medical virology Vol. 95; no. 1; pp. e28152 - n/a
Main Authors: Sibia, Raminderpal Singh, Sood, Ankita, Subedi, Arshula, Sharma, Anushya, Mittal, Anirudh, Singh, Gaaminepreet, Singh, Thakur Gurjeet, Jaura, Ravinder Singh, Goyal, Sanjay
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-01-2023
Subjects:
Alanine
Alanine Transaminase
Aspartate Aminotransferases
Aspartate transaminase
Bilirubin
Biomarkers
C-Reactive Protein
Complications
Cytokines
Dengue
Dengue fever
Dengue hemorrhagic fever
Diagnostic systems
Enzymes
Hematocrit
Hematology
Humans
Infections
Inflammation
Interleukin 6
Interleukin-17
Liver
liver dysfunction
Platelets
Population studies
protease activated receptor‐1
Serum levels
Severe Dengue
shock
Tumor necrosis factor
Tumor Necrosis Factor-alpha
Tumor necrosis factor-TNF
Vector-borne diseases
Virology
protease activated receptor-1
liver dysfunction
inflammation
dengue
shock
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Summary:The present study was designed to check the serum levels of protease‐activated receptor (PAR‐1) in patients during different phases of dengue severity. Moreover, a correlation between serum PAR‐1 levels and hematological parameters, inflammatory cytokine levels, and liver functional changes was also determined. Based on the World Health Organization criteria, the study population was divided into: nonsevere dengue fever (DF; n = 30), severe dengue hemorrhagic fever (DHF; n = 19), and severe dengue shock syndrome (DSS; n = 11). The platelet count (PLT) and hematocrit (HCT) were analyzed using an automated hematology analyzer and liver function enzymes aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphate (ALP), bilirubin were checked by auto‐analyzer using diagnostic kits. Moreover, the levels of inflammatory mediators C‐reactive protein (CRP), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), interleukin‐17 (IL‐17), and PAR‐1 were determined using respective ELISA kits. The HCT levels were elevated and platelet count decreased significantly during dengue complications (DHF and DSS) compared to the DF patients, while the levels of liver functional biomarkers AST, ALT, ALP, and bilirubin remained elevated in DHF and DSS groups than in the corresponding DF group. Similarly, the inflammatory cytokine levels of CRP, TNF‐α, IL‐6, and IL‐17 in DHF and DSS subjects were markedly increased when observed against DF subjects. Notably, the PAR‐1 levels were significantly elevated in DHF and DSS groups than in the DF group and positively correlated with changes in HCT levels, inflammatory biomarkers, and liver enzymes. Our findings conclude that PAR‐1 levels persistently increased with the severity of the dengue infection and are strongly associated with various clinical manifestations. Thus, PAR‐1 levels can be used as a diagnostic marker for assessing dengue severity.
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ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.28152