Search Results - "Sharma, Anita K"

Time course of changes in oxidative stress and stress-induced proteins in cardiomyocytes exposed to doxorubicin and prevention by vitamin C by Ludke, Ana, Akolkar, Gauri, Ayyappan, Prathapan, Sharma, Anita K, Singal, Pawan K

“…We previously reported that Vitamin C (Vit C) protects against doxorubicin (Dox)-induced cardiotoxicity by reducing oxidative stress, p38 mitogen-activated…”
Get full text

Akt regulates IL-10 mediated suppression of TNFα-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation by Dhingra, Sanjiv, Bagchi, Ashim K, Ludke, Ana L, Sharma, Anita K, Singal, Pawan K

“…We have already reported that TNF-α increases cardiomyocyte apoptosis and IL-10 treatment prevented these effects of TNF-α. Present study investigates the role…”
Get full text

Downregulation of vitamin C transporter SVCT-2 in doxorubicin-induced cardiomyocyte injury by Ludke, Ana R, Sharma, Anita K, Akolkar, Gauri, Bajpai, Gunjan, Singal, Pawan K

“…Vitamin C (Vit C) has been shown to be protective against doxorubicin (Dox)-induced cardiotoxicity. However, Vit C uptake into cardiomyocytes is poorly…”
Get more information

IL-10 attenuates TNF-α-induced NFκB pathway activation and cardiomyocyte apoptosis by Dhingra, Sanjiv, Sharma, Anita K., Arora, Rakesh C., Slezak, Jan, Singal, Pawan K.

“…Aims We have recently reported that tumour necrosis factor-α (TNF-α) increases oxidative stress and apoptosis in cardiomyocytes by upregulating p38…”
Get full text

p38 and ERK1/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis by Dhingra, Sanjiv, Sharma, Anita K, Singla, Dinender K, Singal, Pawan K

“…It is known that TNF-alpha increases the production of ROS and decreases antioxidant enzymes, resulting in an increase in oxidative stress. IL-10 appears to…”
Get more information

Subcellular basis of vitamin C protection against doxorubicin-induced changes in rat cardiomyocytes by Ludke, Ana, Sharma, Anita K., Bagchi, Ashim K., Singal, Pawan K.

“…Understanding the molecular basis of doxorubicin (Dox)-induced cardiomyopathy is crucial to finding cardioprotective strategies. Oxidative stress-mediated…”
Get full text

Biology of TNFα and IL-10, and their imbalance in heart failure by Kaur, Kuljeet, Dhingra, Sanjiv, Slezak, Jan, Sharma, Anita K., Bajaj, Anju, Singal, Pawan K.

“…Our understanding of the multiple in vivo functions of the proinflammatory cytokine, tumor necrosis factor (TNFα), is advancing at a rapid pace. In addition to…”
Get full text

Interplay of TNF-α and IL-10 in regulating oxidative stress in isolated adult cardiac myocytes by Kaur, Kuljeet, Sharma, Anita K., Dhingra, Sanjiv, Singal, Pawan K.

“…Oxidative stress and inflammation are considered to be important factors in the pathogenesis of congestive heart failure subsequent to myocardial infarction…”
Get full text

Oleic acid mitigates TNF-α-induced oxidative stress in rat cardiomyocytes by Al-Shudiefat, Abd Al Rahman, Sharma, Anita K., Bagchi, Ashim K., Dhingra, Sanjiv, Singal, Pawan K.

“…Some of the effects of tumor necrosis factor alpha (TNF-α) are suggested to be mediated by oxidative stress. It has also been reported that dietary supplements…”
Get full text

The role of renin angiotensin system antagonists in the prevention of doxorubicin and trastuzumab induced cardiotoxicity by Akolkar, Gauri, Bhullar, Navdeep, Bews, Hilary, Shaikh, Bilal, Premecz, Sheena, Bordun, Kimberly-Ann, Cheung, David Yc, Goyal, Vineet, Sharma, Anita K, Garber, Philip, Singal, Pawan K, Jassal, Davinder S

“…Cardio-Oncology is an evolving discipline that focuses on the management of cancer patients who develop cardiovascular complications as a result of their…”
Get full text

Cardioprotective and antihypertensive effects of Enicostemma littorale Blume extract in fructose-fed rats by Bhatt, Niraj M, Chavda, Meenal, Desai, Dipali, Zalawadia, Rishit, Patel, Vaibhav B, Burade, Vinod, Sharma, Anita K, Singal, Pawan K, Gupta, Sarita

“…We investigated the protective effects of Enicostemma littorale Blume (EL) extract on hypertension and insulin resistance along with its associated…”
Get more information

Adriamycin-induced oxidative stress, activation of MAP kinases and apoptosis in isolated cardiomyocytes by Lou, Huiquan, Kaur, Kuljeet, Sharma, Anita K., Singal, Pawan K.

“…Background: Adriamycin (ADR) induced heart failure is associated with an increase in oxidative stress and apoptosis. Changes due to ADR in mitogen-activated…”
Get full text

Probucol promotes endogenous antioxidant reserve and confers protection against reperfusion injury by Singla, Dinender K, Kaur, Kuljeet, Sharma, Anita K, Dhingra, Sanjiv, Singal, Pawan K

“…The present study examines whether a subchronic probucol treatment of rats offers protection against ischemia-reperfusion (IR) injury in isolated perfused…”
Get more information

Transition from hypertrophy to heart failure in guinea pigs is associated with an increase in apoptosis by Sharma, Anita K, Dhingra, Sanjiv, Khaper, Neelam, Singal, Pawan K

Get full text

288 IL-10 induced cardiomyocyte survival is mediated by CD14 and MyD88 activation by Bagchi, Ashim K, Sharma, Anita K, Lehenbauer Ludke, Ana R, Al-Shudiefat, Abd Al-Rahaman S, Singal, Pawan K

Get full text

Sca‐1 positive cells are more sensitive than adult rat cardiomyocytes to doxorubicin‐induced changes by Ludke, Ana, Sharma, Anita K, Bagchi, Ashim K, Singal, Pawan K

“…Abstract only Cardiac progenitor cells in the adult heart have recently been implicated in Doxorubicin (Dox)‐induced cardiomyopathy. This study compared the…”
Get full text

Oleic acid mitigates TNF-[alpha]-induced oxidative stress in rat cardiomyocytes by Al-shudiefat, Abd Al Rahman, Sharma, Anita K, Bagchi, Ashim K, Dhingra, Sanjiv, Singal, Pawan K

“…Some of the effects of tumor necrosis factor alpha (TNF-α) are suggested to be mediated by oxidative stress. It has also been reported that dietary supplements…”
Get full text

Vitamin C Modulates Doxorubicin-Induced Cardiotoxicity by Reducing P53 and Map Kinase Activation by Ludke, Ana, Sharma, Anita K., Bagchi, Ashim, Singal, Pawan K.

Get full text

Akt Regulates IL-10 Mediated Suppression of TNF[alpha]-Induced Cardiomyocyte Apoptosis by Upregulating Stat3 Phosphorylation by Dhingra, Sanjiv, Bagchi, Ashim K, Ludke, Ana L, Sharma, Anita K, Singal, Pawan K

“…Background We have already reported that TNF-[alpha] increases cardiomyocyte apoptosis and IL-10 treatment prevented these effects of TNF-[alpha]. Present…”
Get full text

IL‐10 promotes cardiomyocyte survival through the activation of Akt and transcription factor Stat3 by Dhingra, Sanjiv, Bagchi, Ashim K, Al‐Shudiefat, Abd Al‐Rahman, Sharma, Anita K, Singal, Pawan K

“…We have already reported that IL‐10 prevents TNF‐α induced increase in oxidative stress and apoptosis in cardiomyocytes. Present study investigated the role of…”
Get full text