Search Results - "Sharma, Amitabh"

Uncovering disease-disease relationships through the incomplete interactome by Menche, Jörg, Sharma, Amitabh, Kitsak, Maksim, Ghiassian, Susan Dina, Vidal, Marc, Loscalzo, Joseph, Barabási, Albert-László

“…A network approach to finding disease modules Shared genes represent a powerful but limited representation of the mechanistic relationship between two…”
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Network Medicine in the Age of Biomedical Big Data by Sonawane, Abhijeet R, Weiss, Scott T, Glass, Kimberly, Sharma, Amitabh

“…Network medicine is an emerging area of research dealing with molecular and genetic interactions, network biomarkers of disease, and therapeutic target…”
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Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets by Vinayagam, Arunachalam, Gibson, Travis E., Lee, Ho-Joon, Yilmazel, Bahar, Roesel, Charles, Hu, Yanhui, Kwon, Young, Sharma, Amitabh, Liu, Yang-Yu, Perrimon, Norbert, Barabási, Albert-László

“…The protein–protein interaction (PPI) network is crucial for cellular information processing and decision-making. With suitable inputs, PPI networks drive the…”
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Robustness and lethality in multilayer biological molecular networks by Liu, Xueming, Maiorino, Enrico, Halu, Arda, Glass, Kimberly, Prasad, Rashmi B., Loscalzo, Joseph, Gao, Jianxi, Sharma, Amitabh

“…Robustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. Here we…”
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Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease by Schlotter, Florian, Halu, Arda, Goto, Shinji, Blaser, Mark C, Body, Simon C, Lee, Lang H, Higashi, Hideyuki, DeLaughter, Daniel M, Hutcheson, Joshua D, Vyas, Payal, Pham, Tan, Rogers, Maximillian A, Sharma, Amitabh, Seidman, Christine E, Loscalzo, Joseph, Seidman, Jonathan G, Aikawa, Masanori, Singh, Sasha A, Aikawa, Elena

“…BACKGROUND:No pharmacological therapy exists for calcific aortic valve disease (CAVD), which confers a dismal prognosis without invasive valve replacement. The…”
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Tissue Specificity of Human Disease Module by Kitsak, Maksim, Sharma, Amitabh, Menche, Jörg, Guney, Emre, Ghiassian, Susan Dina, Loscalzo, Joseph, Barabási, Albert-László

“…Genes carrying mutations associated with genetic diseases are present in all human cells; yet, clinical manifestations of genetic diseases are usually highly…”
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PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation by Iwata, Hiroshi, Goettsch, Claudia, Sharma, Amitabh, Ricchiuto, Piero, Goh, Wilson Wen Bin, Halu, Arda, Yamada, Iwao, Yoshida, Hideo, Hara, Takuya, Wei, Mei, Inoue, Noriyuki, Fukuda, Daiju, Mojcher, Alexander, Mattson, Peter C., Barabási, Albert-László, Boothby, Mark, Aikawa, Elena, Singh, Sasha A., Aikawa, Masanori

“…Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis…”
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Early pregnancy vitamin D status and risk of preeclampsia by Mirzakhani, Hooman, Litonjua, Augusto A, McElrath, Thomas F, O'Connor, George, Lee-Parritz, Aviva, Iverson, Ronald, Macones, George, Strunk, Robert C, Bacharier, Leonard B, Zeiger, Robert, Hollis, Bruce W, Handy, Diane E, Sharma, Amitabh, Laranjo, Nancy, Carey, Vincent, Qiu, Weilliang, Santolini, Marc, Liu, Shikang, Chhabra, Divya, Enquobahrie, Daniel A, Williams, Michelle A, Loscalzo, Joseph, Weiss, Scott T

“…Low vitamin D status in pregnancy was proposed as a risk factor of preeclampsia. We assessed the effect of vitamin D supplementation (4,400 vs. 400 IU/day),…”
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A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses by Ripatti, Samuli, Dr, Tikkanen, Emmi, MSc, Orho-Melander, Marju, Prof, Havulinna, Aki S, MSc, Silander, Kaisa, PhD, Sharma, Amitabh, PhD, Guiducci, Candace, BS, Perola, Markus, Prof, Jula, Antti, MD, Sinisalo, Juha, MD, Lokki, Marja-Liisa, PhD, Nieminen, Markku S, Prof, Melander, Olle, MD, Salomaa, Veikko, Prof, Peltonen, Leena, Prof, Kathiresan, Sekar, MD

“…Summary Background Comparison of patients with coronary heart disease and controls in genome-wide association studies has revealed several single nucleotide…”
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A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma by Sharma, Amitabh, Menche, Jörg, Huang, C Chris, Ort, Tatiana, Zhou, Xiaobo, Kitsak, Maksim, Sahni, Nidhi, Thibault, Derek, Voung, Linh, Guo, Feng, Ghiassian, Susan Dina, Gulbahce, Natali, Baribaud, Frédéric, Tocker, Joel, Dobrin, Radu, Barnathan, Elliot, Liu, Hao, Panettieri, Jr, Reynold A, Tantisira, Kelan G, Qiu, Weiliang, Raby, Benjamin A, Silverman, Edwin K, Vidal, Marc, Weiss, Scott T, Barabási, Albert-László

“…Recent advances in genetics have spurred rapid progress towards the systematic identification of genes involved in complex diseases. Still, the detailed…”
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Network Diffusion Approach to Predict LncRNA Disease Associations Using Multi-Type Biological Networks: LION by Sumathipala, Marissa, Maiorino, Enrico, Weiss, Scott T, Sharma, Amitabh

“…Recently, long-non-coding RNAs (lncRNAs) have attracted attention because of their emerging role in many important biological mechanisms. The accumulating…”
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Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome by Maiorino, Enrico, Baek, Seung Han, Guo, Feng, Zhou, Xiaobo, Kothari, Parul H., Silverman, Edwin K., Barabási, Albert-László, Weiss, Scott T., Raby, Benjamin A., Sharma, Amitabh

“…The molecular and clinical features of a complex disease can be influenced by other diseases affecting the same individual. Understanding disease-disease…”
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Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease by Röhl, Annika, Baek, Seung Han, Kachroo, Priyadarshini, Morrow, Jarrett D, Tantisira, Kelan, Silverman, Edwin K, Weiss, Scott T, Sharma, Amitabh, Glass, Kimberly, DeMeo, Dawn L

“…Chronic obstructive pulmonary disease (COPD) is a leading cause of death in adults that may have origins in early lung development. It is a complex disease,…”
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Endophenotype Network Models: Common Core of Complex Diseases by Ghiassian, Susan Dina, Menche, Jörg, Chasman, Daniel I., Giulianini, Franco, Wang, Ruisheng, Ricchiuto, Piero, Aikawa, Masanori, Iwata, Hiroshi, Müller, Christian, Zeller, Tania, Sharma, Amitabh, Wild, Philipp, Lackner, Karl, Singh, Sasha, Ridker, Paul M., Blankenberg, Stefan, Barabási, Albert-László, Loscalzo, Joseph

“…Historically, human diseases have been differentiated and categorized based on the organ system in which they primarily manifest. Recently, an alternative view…”
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Mechanical forces induce an asthma gene signature in healthy airway epithelial cells by Kılıç, Ayşe, Ameli, Asher, Park, Jin-Ah, Kho, Alvin T., Tantisira, Kelan, Santolini, Marc, Cheng, Feixiong, Mitchel, Jennifer A., McGill, Maureen, O’Sullivan, Michael J., De Marzio, Margherita, Sharma, Amitabh, Randell, Scott H., Drazen, Jeffrey M., Fredberg, Jeffrey J., Weiss, Scott T.

“…Bronchospasm compresses the bronchial epithelium, and this compressive stress has been implicated in asthma pathogenesis. However, the molecular mechanisms by…”
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Author Correction: Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome by Maiorino, Enrico, Baek, Seung Han, Guo, Feng, Zhou, Xiaobo, Kothari, Parul H., Silverman, Edwin K., Barabási, Albert-László, Weiss, Scott T., Raby, Benjamin A., Sharma, Amitabh

“…A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22939-x…”
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A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks by Zhou, Xuezhong, Lei, Lei, Liu, Jun, Halu, Arda, Zhang, Yingying, Li, Bing, Guo, Zhili, Liu, Guangming, Sun, Changkai, Loscalzo, Joseph, Sharma, Amitabh, Wang, Zhong

“…The International Classification of Diseases (ICD) relies on clinical features and lags behind the current understanding of the molecular specificity of…”
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Integrating personalized gene expression profiles into predictive disease-associated gene pools by Menche, Jörg, Guney, Emre, Sharma, Amitabh, Branigan, Patrick J., Loza, Matthew J., Baribaud, Frédéric, Dobrin, Radu, Barabási, Albert-László

“…Gene expression data are routinely used to identify genes that on average exhibit different expression levels between a case and a control group. Yet, very few…”
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Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation by Halu, Arda, Wang, Jian-Guo, Iwata, Hiroshi, Mojcher, Alexander, Abib, Ana Luisa, Singh, Sasha A, Aikawa, Masanori, Sharma, Amitabh

“…The role of pro-inflammatory macrophage activation in cardiovascular disease (CVD) is a complex one amenable to network approaches. While an indispensible tool…”
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Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling by Nakano, Toshiaki, Katsuki, Shunsuke, Chen, Mingxian, Decano, Julius L, Halu, Arda, Lee, Lang Ho, Pestana, Diego V S, Kum, Angelo S T, Kuromoto, Rodrigo K, Golden, Whitney S, Boff, Mario S, Guimaraes, Gabriel C, Higashi, Hideyuki, Kauffman, Kevin J, Maejima, Takashi, Suzuki, Takehiro, Iwata, Hiroshi, Barabási, Albert-László, Aster, Jon C, Anderson, Daniel G, Sharma, Amitabh, Singh, Sasha A, Aikawa, Elena, Aikawa, Masanori

“…Chronic kidney disease (CKD) increases cardiovascular risk. Underlying mechanisms, however, remain obscure. The uremic toxin indoxyl sulfate is an independent…”
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