Search Results - "Sharma, Ajit K."

Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation by O’Sullivan, Julia, Tedim Ferreira, Maria, Gagné, Jean-Philippe, Sharma, Ajit K., Hendzel, Michael J., Masson, Jean-Yves, Poirier, Guy G.

“…Protein ADP-ribosylation is essential for the regulation of several cellular pathways, enabling dynamic responses to diverse pathophysiological conditions. It…”
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Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks by Caron, Marie-Christine, Sharma, Ajit K., O’Sullivan, Julia, Myler, Logan R., Ferreira, Maria Tedim, Rodrigue, Amélie, Coulombe, Yan, Ethier, Chantal, Gagné, Jean-Philippe, Langelier, Marie-France, Pascal, John M., Finkelstein, Ilya J., Hendzel, Michael J., Poirier, Guy G., Masson, Jean-Yves

“…PARP-1 is rapidly recruited and activated by DNA double-strand breaks (DSBs). Upon activation, PARP-1 synthesizes a structurally complex polymer composed of…”
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BMI-1 regulates DNA end resection and homologous recombination repair by Fitieh, Amira, Locke, Andrew J., Mashayekhi, Fatemeh, Khaliqdina, Fajr, Sharma, Ajit K., Ismail, Ismail Hassan

“…BMI-1 is an essential regulator of transcriptional silencing during development. Recently, the role of BMI-1 in the DNA damage response has gained much…”
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Protocol to measure end resection intermediates at sequence-specific DNA double-strand breaks by quantitative polymerase chain reaction using ER-AsiSI U2OS cells by Sharma, Ajit K., Fitieh, Amira Mohammed, Hafez Ali, Jana Yasser, Ismail, Ismail Hassan

“…DNA end resection is a critical step in the homologous recombination pathway of repairing DNA double-strand breaks (DSBs) that can be visualized in cells by…”
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Quantification of protein enrichment at site-specific DNA double-strand breaks by chromatin immunoprecipitation in cultured human cells by Sharma, Ajit K., Fitieh, Amira Mohammed, Locke, Andrew J., Ali, Jana Yasser Hafez, Ismail, Ismail Hassan

“…Here, we present a chromatin-immunoprecipitation-based protocol to quantify the recruitment of proteins adjacent to site-specific DNA double-strand breaks…”
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Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma by Khan, Shafqat A, Tyagi, Monica, Sharma, Ajit K, Barreto, Savio G, Sirohi, Bhawna, Ramadwar, Mukta, Shrikhande, Shailesh V, Gupta, Sanjay

“…AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological…”
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Surfactant-aided sol-gel synthesis of TiO2–MgO nanocomposite and their photocatalytic azo dye degradation activity by Sharma, Ajit K, Lee, Byeong-Kyu

“…In this work, a surfactant-aided TiO2–MgO nanocomposite (Ti-M-S) was successfully synthesized by a sol-gel process with the aid of sodium dodecyl sulfate as a…”
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The relationship between histone posttranslational modification and DNA damage signaling and repair by Sharma, Ajit K, Hendzel, Michael J.

“…Purpose: The cellular response to DNA damage occurs in the context of an organized chromatin environment in order to maintain genome integrity. Immediately…”
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Molecular Modeling of Differentially Phosphorylated Serine 10 and Acetylated lysine 9/14 of Histone H3 Regulates their Interactions with 14-3-3ζ, MSK1, and MKP1 by Sharma, Ajit K., Mansukh, Abhilasha, Varma, Ashok, Gadewal, Nikhil, Gupta, Sanjay

“…Histone modifications occur in precise patterns, with several modifications known to affect the binding of proteins. These interactions affect the chromatin…”
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Techniques to access histone modifications and variants in cancer by Tyagi, Monica, Khan, Shafqat A, Bhattacharya, Saikat, Reddy, Divya, Sharma, Ajit K, Khade, Bharat, Gupta, Sanjay

“…Recent years have witnessed an explosion of epigenetic research on the role of histone variants and modifications in cancer. To understand the global dynamics…”
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Dynamic alteration in H3 serine 10 phosphorylation is G1-phase specific during ionization radiation induced DNA damage response in human cells by Sharma, Ajit K, Bhattacharya, Saikat, Khan, Shafqat A, Khade, Bharat, Gupta, Sanjay

“…Chromatin acts as a natural barrier in DNA-damage recognition and repair. Histones undergo differential post-translational modification(s) to facilitate DNA…”
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MKP1 phosphatase mediates G1-specific dephosphorylation of H3Serine10P in response to DNA damage by Sharma, Ajit K, Khan, Shafqat A, Sharda, Asmita, Reddy, Divya V, Gupta, Sanjay

“…Histone mark, H3S10 phosphorylation plays a dual role in a cell by maintaining relaxed chromatin for active transcription in interphase and condensed chromatin…”
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Microwave accelerated synthesis and characterization of poly(acrylamide) by Singh, Vandana, Tiwari, Ashutosh, Kumari, Premlata, Sharma, Ajit K.

“…Poly(acrylamide) (PAM) was efficiently synthesized under microwave (MW) irradiation using catalytic amount of potassium persulfate. The synthesis does not…”
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Conservation strategies for threatened medicinal plant – Barleria prionitis L. – using in vitro and ex vitro propagation techniques by Lone, Shabir A, Yadav, A.S, Bajaj, A, Sharma, Ajit K, Badkhane, Yogesh, Raghuwanshi, D.K

“…Over-utilisation and continuous depletion of medicinal plants have affected their supply and loss of genetic diversity. Hence the current study is based on…”
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Preparation of novel carbon microfiber/carbon nanofiber-dispersed polyvinyl alcohol-based nanocomposite material for lithium-ion electrolyte battery separator by Sharma, Ajit K., Khare, Prateek, Singh, Jayant K., Verma, Nishith

“…A novel nanocomposite polyvinyl alcohol precursor-based material dispersed with the web of carbon microfibers and carbon nanofibers is developed as lithium…”
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Surfactant-aided sol-gel synthesis of TiO 2 –MgO nanocomposite and their photocatalytic azo dye degradation activity by Sharma, Ajit K, Lee, Byeong-Kyu

“…In this work, a surfactant-aided TiO 2 –MgO nanocomposite (Ti-M-S) was successfully synthesized by a sol-gel process with the aid of sodium dodecyl sulfate as…”
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Design, synthesis, and biological evaluation of novel 2,4-thiazolidinedione derivatives as histone deacetylase inhibitors targeting liver cancer cell line by Mohan, Rhea, Sharma, Ajit K., Gupta, Sanjay, Ramaa, C. S.

“…As a part of an ongoing effort to find alternate chemotherapeutic agents for hepatocellular carcinoma, we herein, report the design and synthesis of two novel…”
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Molecular modeling of differentially phosphorylated serine 10 and acetylated lysine 9/14 of histone H3 regulates their interactions with 14-3-3θ, MSK1, and MKP1 by Sharma, Ajit K, Mansukh, Abhilasha, Varma, Ashok, Gadewal, Nikhil, Gupta, Sanjay

“…Histone modifications occur in precise patterns, with several modifications known to affect the binding of proteins. These interactions affect the chromatin…”
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Molecular Modeling of Differentially Phosphorylated Serine 10 and Acetylated lysine 9/14 of Histone H3 Regulates their Interactions with 14-3-3ζ, MSK1, and MKP1 by Ajit K. Sharma, Abhilasha Mansukh, Ashok Varma, Nikhil Gadewal, Sanjay Gupta

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