Search Results - "Sharlow, Elizabeth"

Drugging Undruggable Molecular Cancer Targets by Lazo, John S, Sharlow, Elizabeth R

“…Cancer, more than any other human disease, now has a surfeit of potential molecular targets poised for therapeutic exploitation. Currently, a number of…”
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Emerging drug discovery ecosystems by Sharlow, Elizabeth R

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Revisiting Repurposing by Sharlow, Elizabeth R

“…Drug repurposing can be a cost-effective strategy to identify new small molecule-based therapies. Thus, drug repurposing significantly influences the discovery…”
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Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations by Sharlow, Elizabeth R, Llaneza, Danielle C, Tewari, Bhanu P, Mingledorff, Garnett A, Mendelson, Anna J, Sontheimer, Harald, Bloom, George S, Lazo, John S

“…Neuronal differentiation and maturation are extended developmental processes. To determine whether neurons at different developmental stages have divergent…”
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Small molecule targeting of PTPs in cancer by Lazo, John S., McQueeney, Kelley E., Burnett, James C., Wipf, Peter, Sharlow, Elizabeth R.

“…[Display omitted] Protein tyrosine phosphatases (PTPs) undeniably have a central role in the development and progression of human cancers. Historically,…”
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Deactivation of STAT3 and ERK and Activation of p38 in Ovarian Cancer Cells Treated with a Small Molecule Inhibitor of PTP4A3 Phosphatase by Lazo, John S., Isbell, Kelly N., Rastelli, Ettore J., Wipf, Peter, Sharlow, Elizabeth R.

“…The Protein Tyrosine Phosphatase of Regenerating Liver‐3, also known as PRL‐3 or PTP4A3, is among the most oncogenic known protein tyrosine phosphatases,…”
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Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase by Lazo, John S, Isbell, Kelly N, Vasa, Sai Ashish, Llaneza, Danielle C, Rastelli, Ettore J, Wipf, Peter, Sharlow, Elizabeth R

“…Protein tyrosine phosphatase type IVA member 3 (PTP4A3 or PRL-3) is a nonreceptor, oncogenic, dual-specificity phosphatase that is highly expressed in many…”
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Introduction to the iPS Cells for Ischemic Stroke, Traumatic Brain Injury, and Other Brain-Related Diseases Special Issue by Sharlow, Guest Editor, Elizabeth R

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Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer's Disease and Brain Insulin Resistance, and Its Relation to Cancer by Koseoglu, Mehmet Murat, Norambuena, Andrés, Sharlow, Elizabeth R, Lazo, John S, Bloom, George S

“…Aberrant neuronal cell cycle re-entry (CCR) is a phenomenon that precedes and may mechanistically lead to a majority of the neuronal loss observed in…”
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The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells by Colunga Biancatelli, Ruben M L, Solopov, Pavel A, Sharlow, Elizabeth R, Lazo, John S, Marik, Paul E, Catravas, John D

“…Acute lung injury (ALI) leading to acute respiratory distress syndrome is the major cause of COVID-19 lethality. Cell entry of SARS-CoV-2 occurs via the…”
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Chemical genetics of Plasmodium falciparum by Guy, R. Kiplin, Guiguemde, W. Armand, Shelat, Anang A, Bouck, David, Duffy, Sandra, Crowther, Gregory J, Davis, Paul H, Smithson, David C, Connelly, Michele, Clark, Julie, Zhu, Fangyi, Jiménez-Díaz, María B, Martinez, María S, Wilson, Emily B, Tripathi, Abhai K, Gut, Jiri, Sharlow, Elizabeth R, Bathurst, Ian, Mazouni, Farah El, Fowble, Joseph W, Forquer, Isaac, McGinley, Paula L, Castro, Steve, Angulo-Barturen, Iñigo, Ferrer, Santiago, Rosenthal, Philip J, DeRisi, Joseph L, Sullivan, David J, Lazo, John S, Roos, David S, Riscoe, Michael K, Phillips, Margaret A, Rathod, Pradipsinh K, Van Voorhis, Wesley C, Avery, Vicky M

“…Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and…”
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Benefits of Strategic Small-Scale Targeted Screening by Sharlow, Elizabeth R

“…High-throughput screening (HTS) is a key technology platform for the discovery of chemical probes and identification of potential drug leads. Once mainly found…”
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Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor by Salamoun, Joseph M, McQueeney, Kelley E, Patil, Kalyani, Geib, Steven J, Sharlow, Elizabeth R, Lazo, John S, Wipf, Peter

“…The phosphatase PTP4A3 is an attractive anticancer target, but knowledge of its exact role in cells remains incomplete. A potent, structurally novel inhibitor…”
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Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway by Rastelli, Ettore J., Sannino, Sara, Hart, Duncan J., Sharlow, Elizabeth R., Lazo, John S., Brodsky, Jeffrey L., Wipf, Peter

“…[Display omitted] We developed JMS-053, a potent inhibitor of the dual specificity phosphatase PTP4A3 that is potentially suitable for cancer therapy. Due to…”
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Transcriptome and Translatome Regulation of Pathogenesis in Alzheimer's Disease Model Mice by Eastman, Guillermo, Sharlow, Elizabeth R, Lazo, John S, Bloom, George S, Sotelo-Silveira, José R

“…Defining cellular mechanisms that drive Alzheimer's disease (AD) pathogenesis and progression will be aided by studies defining how gene expression patterns…”
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Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase by Lazo, John S, Blanco, Isabella K, Tasker, Nikhil R, Rastelli, Ettore J, Burnett, James C, Garrott, Sharon R, Hart, Duncan J, McCloud, Rebecca L, Hsu, Ku-Lung, Wipf, Peter, Sharlow, Elizabeth R

“…Oncogenic protein tyrosine phosphatases (PTPs) are overexpressed in numerous human cancers but they have been challenging pharmacological targets. The…”
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Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors by Tasker, Nikhil R., Rastelli, Ettore J., Burnett, James C., Sharlow, Elizabeth R., Lazo, John S., Wipf, Peter

“…[Display omitted] A Digest of protein tyrosine phosphatase 4A inhibitors is presented. Protein tyrosine phosphatases (PTPs) are emerging new targets for drug…”
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A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype by Porterfield, Veronica, Khan, Shahzad S., Foff, Erin P., Koseoglu, Mehmet Murat, Blanco, Isabella K., Jayaraman, Sruthi, Lien, Eric, McConnell, Michael J., Bloom, George S., Lazo, John S., Sharlow, Elizabeth R.

“…A hexanucleotide repeat expansion on chromosome 9 open reading frame 72 (C9orf72) is associated with familial amyotrophic lateral sclerosis (ALS) and a…”
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Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin by Czub, Mateusz P, Boulton, Adam M, Rastelli, Ettore J, Tasker, Nikhil R, Maskrey, Taber S, Blanco, Isabella K, McQueeney, Kelley E, Bushweller, John H, Minor, Wladek, Wipf, Peter, Sharlow, Elizabeth R, Lazo, John S

“…Protein tyrosine phosphatase (PTP) 4A3 is frequently overexpressed in human solid tumors and hematologic malignancies and is associated with tumor cell…”
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Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells by Chokshi, Chirayu R., Shaikh, Muhammad Vaseem, Brakel, Benjamin, Rossotti, Martin A., Tieu, David, Maich, William, Anand, Alisha, Chafe, Shawn C., Zhai, Kui, Suk, Yujin, Kieliszek, Agata M., Miletic, Petar, Mikolajewicz, Nicholas, Chen, David, McNicol, Jamie D., Chan, Katherine, Tong, Amy H. Y., Kuhlmann, Laura, Liu, Lina, Alizada, Zahra, Mobilio, Daniel, Tatari, Nazanin, Savage, Neil, Aghaei, Nikoo, Grewal, Shan, Puri, Anish, Subapanditha, Minomi, McKenna, Dillon, Ignatchenko, Vladimir, Salamoun, Joseph M., Kwiecien, Jacek M., Wipf, Peter, Sharlow, Elizabeth R., Provias, John P., Lu, Jian-Qiang, Lazo, John S., Kislinger, Thomas, Lu, Yu, Brown, Kevin R., Venugopal, Chitra, Henry, Kevin A., Moffat, Jason, Singh, Sheila K.

“…Resistance to genotoxic therapies and tumor recurrence are hallmarks of glioblastoma (GBM), an aggressive brain tumor. In this study, we investigated…”
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