Search Results - "Sharland, A. F."

Infiltrating Foxp3+ Regulatory T Cells From Spontaneously Tolerant Kidney Allografts Demonstrate Donor‐Specific Tolerance by Hu, M., Wang, C., Zhang, G. Y., Saito, M., Wang, Y. M., Fernandez, M. A., Wang, Y., Wu, H., Hawthorne, W. J., Jones, C., O'Connell, P. J., Sparwasser, T., Bishop, G. A., Sharland, A. F., Alexander, S. I.

“…Foxp3+ regulatory T cells (Tregs) have an essential role in immune and allograft tolerance. However, in both kidney and liver transplantation in humans, FOXP3+…”
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Posttransplant Administration of Donor Leukocytes Induces Long-Term Acceptance of Kidney or Liver Transplants by an Activation-Associated Immune Mechanism by Yan, Yiqun, Shastry, Suma, Richards, Craig, Wang, Chuanmin, Bowen, David G, Sharland, Alexandra F, Painter, Dorothy M, McCaughan, Geoffrey W, Bishop, G. Alex

“…Donor leukocytes play a dual role in rejection and acceptance of transplanted organs. They provide the major stimulus for rejection, and their removal from the…”
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Paradoxical early immune activation during acceptance of liver allografts compared with rejection of skin grafts in a rat model of transplantation by Rokahr, K L, Sharland, A F, Sun, J, Wang, C, Sheil, A G, Yan, Y, McCaughan, G W, Bishop, G A

“…Liver allografts in many animal models are often spontaneously accepted across a complete histocompatibility barrier without requirement for immunosuppression…”
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Is the T helper 1/T helper 2 paradigm of allograft tolerance dead or has it just been turned upside down? by McCaughan, G W, Sharland, A F, Bishop, G A

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Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance by McCaughan, Geoffrey W., Gorrell, Mark D., Bishop, G. Alex, Abbott, Catherine A., Shackel, Nicholas A., McGuinness, Peter H., Levy, Miriam T., Sharland, Alexandra F., Bowen, David G., Yu, Denise, Slaitini, Loubnah, Church, W. Bret, Napoli, John

“…The hallmarks of chronic liver diseases are chronic inflammation, cellular damage, regeneration and fibrosis. An appreciation of intrahepatic molecular…”
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Spontaneous acceptance of liver transplants in rodents: Evidence that liver leucocytes induce recipient T-cell death by neglect by Bishop, G Alex, Wang, Chuanmin, Sharland, Alexandra F, McCaughan, Geoffrey W

“…In many animal models transplanted livers are not rejected, even when there is a complete MHC mismatch between the donor and recipient and the recipient is not…”
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Outcomes of Two Different Methods of Ureteric Anastomosis in a Mouse Kidney Transplant Model: 1587 by Wang, C., Wang, Z. Z., Cunningham, E. C., Allen, R. D., Sharland, A. F., Bishop, A.

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Outcomes of Two Different Methods of Ureteric Anastomosis in a Mouse Kidney Transplant Model: 1587 by Wang, C., Wang, Z. Z., Cunningham, E. C., Allen, R. D., Sharland, A. F., Bishop, A.

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Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts by Cunningham, Eithne C, Tay, Szun S, Wang, Chuanmin, Rtshiladze, Michael, Wang, Zane Z, McGuffog, Claire, Cubitt, Jonathan, McCaughan, Geoffrey W, Alexander, Ian E, Bertolino, Patrick, Sharland, Alexandra F, Bowen, David G, Bishop, G Alex

“…The liver has long been recognized as having tolerogenic properties. We investigated whether recombinant adenoassociated virus (rAAV)-mediated expression of…”
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Blocking Indoleamine Dioxygenase Activity Early After Rat Liver Transplantation Prevents Long-Term Survival But Does Not Cause Acute Rejection by LAURENCE, Jerome M, CHUANMIN WANG, PARK, Euiyoun T, BUCHANAN, Alexandra, CLOUSTON, Andrew, ALIEN, Richard D. M, MCCAUGHAN, Geoffrey W, BISHOP, G. Alex, SHARLAND, Alexandra F

“…In a well-characterized rat model of liver transplantation, Piebald Virol Glaxo strain livers are accepted long term in fully mismatched Dark Agouti recipients…”
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PORCINE CELLS EXPRESS LIGANDS FOR THE HUMAN NK CELL ACTIVATING RECEPTOR NKG2D by Sharland, A F, Christiansen, D, Tran, P, Winterhalter, A, Brooks, A, Sandrin, M S

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HORMONAL RESUSCITATION HAS BENEFICIAL EFFECTS ON DONOR PULMONARY FUNCTION IN A PORCINE MODEL OF BRAIN-DEAD ORGAN DONATION: 1830 by Watson, A J., Hicks, M, Gao, L, Jabbour, A, Faddy, S C., Kesteven, S H., Sharland, A F., Allen, R D.M., Jansz, P C., Macdonald, P S.

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Postoperative administration of donor B cells induces rat kidney allograft acceptance: Lack of association with Th2 cytokine expression in long-term accepted grafts by YIQUN YAN, VAN DER PUTTEN, Karien, BOWEN, David G, PAINTER, Dorothy M, KOHAR, Jimmy, SHARLAND, Alexandra F, MCCAUGHAN, Geoffrey W, BISHOP, G. Alex

“…Although donor leukocytes are only thought to prolong survival when administered before transplantation, recent evidence shows that they are effective at…”
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Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance by McCaughan, G W, Gorrell, MD, Bishop, G A, Abbott, CA, Shackel, NA, McGuinness, PH, Levy, M T, Sharland, A F, Bowen, D G, Yu, D, Slaitini, L, Church, W B, Napoli, J

“…The hallmarks of chronic liver diseases are chronic inflammation, cellular damage, regeneration and fibrosis. An appreciation of intrahepatic molecular…”
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Molecular pathogenesis of liver disease : An approach to hepatic inflammation, cirrhosis and liver transplant tolerance: Disease and defense in the liver by MCCAUGHAN, G. W, GORRELL, M. D, SLAITINI, L, CHURCH, W. B, NAPOLI, J, BISHOP, G. A, ABBOTT, C. A, SHACKEL, N. A, MCGUINNESS, P. H, LEVY, M. T, SHARLAND, A. F, BOWEN, D. G, YU, D

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