Search Results - "Sharkey, Kieran J"

Divide-and-conquer: machine-learning integrates mammalian and viral traits with network features to predict virus-mammal associations by Wardeh, Maya, Blagrove, Marcus S. C., Sharkey, Kieran J., Baylis, Matthew

“…Our knowledge of viral host ranges remains limited. Completing this picture by identifying unknown hosts of known viruses is an important research aim that can…”
Get full text

Deterministic epidemic models on contact networks: Correlations and unbiological terms by Sharkey, Kieran J.

“…The relationship between system-level and subsystem-level master equations is investigated and then utilised for a systematic and potentially automated…”
Get full text

Deterministic epidemiological models at the individual level by Sharkey, Kieran J.

“…In many fields of science including population dynamics, the vast state spaces inhabited by all but the very simplest of systems can preclude a deterministic…”
Get full text

The Differential Warming Response of Britain's Rivers (1982-2011) by Jonkers, Art R T, Sharkey, Kieran J

“…River water temperature is a hydrological feature primarily controlled by topographical, meteorological, climatological, and anthropogenic factors. For…”
Get full text

Effectiveness of the BNT162b2 (Pfizer-BioNTech) and the ChAdOx1 nCoV-19 (Oxford-AstraZeneca) vaccines for reducing susceptibility to infection with the Delta variant (B.1.617.2) of SARS-CoV-2 by Pattni, Karan, Hungerford, Daniel, Adams, Sarah, Buchan, Iain, Cheyne, Christopher P, García-Fiñana, Marta, Hall, Ian, Hughes, David M, Overton, Christopher E, Zhang, Xingna, Sharkey, Kieran J

“…From January to May 2021 the alpha variant (B.1.1.7) of SARS-CoV-2 was the most commonly detected variant in the UK. Following this, the Delta variant…”
Get full text

Deterministic epidemic models overestimate the basic reproduction number of observed outbreaks by Ali, Wajid, Overton, Christopher E., Wilkinson, Robert R., Sharkey, Kieran J.

“…The basic reproduction number, R0, is a well-known quantifier of epidemic spread. However, a class of existing methods for estimating R0 from incidence data…”
Get full text

Aortic stenosis post-COVID-19: a mathematical model on waiting lists and mortality by Stickels, Christian Philip, Nadarajah, Ramesh, Gale, Chris P, Jiang, Houyuan, Sharkey, Kieran J, Gibbison, Ben, Holliman, Nick, Lombardo, Sara, Schewe, Lars, Sommacal, Matteo, Sun, Louise, Weir-McCall, Jonathan, Cheema, Katherine, Rudd, James H F, Mamas, Mamas, Erhun, Feryal

“…ObjectivesTo provide estimates for how different treatment pathways for the management of severe aortic stenosis (AS) may affect National Health Service (NHS)…”
Get full text

Impact of climatic, demographic and disease control factors on the transmission dynamics of COVID-19 in large cities worldwide by Metelmann, Soeren, Pattni, Karan, Brierley, Liam, Cavalerie, Lisa, Caminade, Cyril, Blagrove, Marcus S.C., Turner, Joanne, Sharkey, Kieran J., Baylis, Matthew

“…Approximately a year into the COVID-19 pandemic caused by the SARS-CoV-2 virus, many countries have seen additional “waves” of infections, especially in the…”
Get full text

An exact relationship between invasion probability and endemic prevalence for Markovian SIS dynamics on networks by Wilkinson, Robert R, Sharkey, Kieran J

“…Understanding models which represent the invasion of network-based systems by infectious agents can give important insights into many real-world situations,…”
Get full text

Impact of the infectious period on epidemics by Wilkinson, Robert R, Sharkey, Kieran J

“…The duration of the infectious period is a crucial determinant of the ability of an infectious disease to spread. We consider an epidemic model that is network…”
Get more information

A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions by Kotze, Helen L, Armitage, Emily G, Sharkey, Kieran J, Allwood, James W, Dunn, Warwick B, Williams, Kaye J, Goodacre, Royston

“…Metabolomics has become increasingly popular in the study of disease phenotypes and molecular pathophysiology. One branch of metabolomics that encompasses the…”
Get full text

Integration of shared-pathogen networks and machine learning reveals the key aspects of zoonoses and predicts mammalian reservoirs by Wardeh, Maya, Sharkey, Kieran J, Baylis, Matthew

“…Diseases that spread to humans from animals, zoonoses, pose major threats to human health. Identifying animal reservoirs of zoonoses and predicting future…”
Get full text

Epidemiological consequences of an incursion of highly pathogenic H5N1 avian influenza into the British poultry flock by Sharkey, Kieran J, Bowers, Roger G, Morgan, Kenton L, Robinson, Susan E, Christley, Robert M

“…Highly pathogenic avian influenza and in particular the H5N1 strain has resulted in the culling of millions of birds and continues to pose a threat to poultry…”
Get full text

A control analysis perspective on Katz centrality by Sharkey, Kieran J.

“…Methods for efficiently controlling dynamics propagated on networks are usually based on identifying the most influential nodes. Knowledge of these nodes can…”
Get full text

Eco-evolutionary dynamics in finite network-structured populations with migration by Pattni, Karan, Ali, Wajid, Broom, Mark, Sharkey, Kieran J.

“…We consider the effect of network structure on the evolution of a population. Models of this kind typically consider a population of fixed size and…”
Get full text

Evolutionary graph theory derived from eco-evolutionary dynamics by Pattni, Karan, Overton, Christopher E., Sharkey, Kieran J.

“…•Evolutionary graph theory (EGT) is derived from an eco-evolutionary dynamics model.•Extreme assumptions leading to departure from ecological processes are…”
Get full text

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity by Leedale, Joseph, Sharkey, Kieran J., Colley, Helen E., Norton, Áine M., Peeney, David, Mason, Chantelle L., Sathish, Jean G., Murdoch, Craig, Sharma, Parveen, Webb, Steven D.

“…Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent…”
Get full text

Discrete-time moment closure models for epidemic spreading in populations of interacting individuals by Frasca, Mattia, Sharkey, Kieran J.

“…Understanding the dynamics of spread of infectious diseases between individuals is essential for forecasting the evolution of an epidemic outbreak or for…”
Get full text

Methods for approximating stochastic evolutionary dynamics on graphs by Overton, Christopher E., Broom, Mark, Hadjichrysanthou, Christoforos, Sharkey, Kieran J.

“…•Population structure can have a significant impact on the outcome of evolution.•Using techniques from physics we approximate evolutionary dynamics on…”
Get full text

Evolutionary bet-hedging in structured populations by Overton, Christopher E., Sharkey, Kieran J.

“…As ecosystems evolve, species can become extinct due to fluctuations in the environment. This leads to the evolutionary adaption known as bet-hedging, where…”
Get full text