Search Results - "Sharkey, David"

Seminal fluid and fertility in women by Robertson, Sarah A., Ph.D, Sharkey, David J., Ph.D

“…Seminal fluid is often viewed as simply a vehicle to carry sperm to fertilize the oocyte, but a more complex function in influencing female reproductive…”
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Immune Cells at the Fetomaternal Interface: How the Microenvironment Modulates Immune Cells To Foster Fetal Development by Schumacher, Anne, Sharkey, David J, Robertson, Sarah A, Zenclussen, Ana C

“…Immune cells adapt their phenotypic and functional characteristics in response to the tissue microenvironment within which they traffic and reside. The…”
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Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus by Sharkey, David J, Tremellen, Kelton P, Jasper, Melinda J, Gemzell-Danielsson, Kristina, Robertson, Sarah A

“…In mice, seminal fluid elicits an inflammation-like response in the female genital tract that activates immune adaptations to advance the likelihood of…”
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TLR4 Signaling Is a Major Mediator of the Female Tract Response to Seminal Fluid in Mice by Schjenken, John E, Glynn, Danielle J, Sharkey, David J, Robertson, Sarah A

“…Seminal fluid interacts with epithelial cells lining the female reproductive tract to induce expression of proinflammatory cytokines and chemokines, initiating…”
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Seminal Fluid and the Generation of Regulatory T Cells for Embryo Implantation by Robertson, Sarah A., Prins, Jelmer R., Sharkey, David J., Moldenhauer, Lachlan M.

“…T regulatory (Treg) cells are essential mediators of the maternal immune adaptation necessary for embryo implantation. In mice, insufficient Treg cell activity…”
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TGF-β mediates proinflammatory seminal fluid signaling in human cervical epithelial cells by Sharkey, David J, Macpherson, Anne M, Tremellen, Kelton P, Mottershead, David G, Gilchrist, Robert B, Robertson, Sarah A

“…The cervix is central to the female genital tract immune response to pathogens and foreign male Ags introduced at coitus. Seminal fluid profoundly influences…”
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Roles of male reproductive tract extracellular vesicles in reproduction by Tamessar, Cottrell T., Trigg, Natalie A., Nixon, Brett, Skerrett‐Byrne, David A., Sharkey, David J., Robertson, Sarah A., Bromfield, Elizabeth G., Schjenken, John E.

“…Sources of extracellular vesicles within the male reproductive tract. Given that the secretion of extracellular vesicles (EVs) is a virtually ubiquitous…”
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High-fat Diet Alters Male Seminal Plasma Composition to Impair Female Immune Adaptation for Pregnancy in Mice by Schjenken, John E, Moldenhauer, Lachlan M, Sharkey, David J, Chan, Hon Y, Chin, Peck Y, Fullston, Tod, McPherson, Nicole O, Robertson, Sarah A

“…Abstract Paternal experiences and exposures before conception can influence fetal development and offspring phenotype. The composition of seminal plasma…”
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Plasma miRNAs Display Limited Potential as Diagnostic Tools for Endometriosis by Nisenblat, Victoria, Sharkey, David J, Wang, Zhao, Evans, Susan F, Healey, Martin, Ohlsson Teague, E Maria C, Print, Cristin G, Robertson, Sarah A, Hull, M Louise

“…Despite extensive searches for novel noninvasive diagnostics, laparoscopy remains the reference test for endometriosis. Circulating miRNAs are purported…”
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Regulatory T Cell Proportion and Phenotype Are Altered in Women Using Oral Contraception by Moldenhauer, Lachlan M, Jin, Min, Wilson, Jasmine J, Green, Ella S, Sharkey, David J, Salkeld, Mark D, Bristow, Thomas C, Hull, M Louise, Dekker, Gustaaf A, Robertson, Sarah A

“…Abstract Regulatory T (Treg) cells are a specialized CD4+ T cell subpopulation that are essential for immune homeostasis, immune tolerance, and protection…”
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Measuring Reactive Oxygen Species in Semen for Male Preconception Care: A Scientist Perspective by Castleton, Patience E, Deluao, Joshua C, Sharkey, David J, McPherson, Nicole O

“…Oxidative stress and elevated levels of seminal and sperm reactive oxygen species (ROS) may contribute to up to 80% of male infertility diagnosis, with sperm…”
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Assessing the influence of preconception diet on male fertility: a systematic scoping review by Tully, Cathryn A, Alesi, Simon, McPherson, Nicole O, Sharkey, David J, Teong, Xiao Tong, Tay, Chau Thien, Silva, Thais Rasia, Puglisi, Carolyn, Barsby, Jacqueline P, Moran, Lisa J, Grieger, Jessica A, Mousa, Aya

“…The last decade has seen increased research on the relationship between diet and male fertility, but there are no clearly defined nutritional recommendations…”
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Toll-Like Receptor-4 Antagonist (+)-Naloxone Confers Sexually Dimorphic Protection From Inflammation-Induced Fetal Programming in Mice by Chin, Peck Yin, Dorian, Camilla, Sharkey, David J, Hutchinson, Mark R, Rice, Kenner C, Moldenhauer, Lachlan M, Robertson, Sarah A

“…Inflammation elicited by infection or noninfectious insults during gestation induces proinflammatory cytokines that can shift the trajectory of development to…”
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Seminal plasma transforming growth factor-β, activin A and follistatin fluctuate within men over time by Sharkey, David J., Tremellen, Kelton P., Briggs, Nancy E., Dekker, Gustaaf A., Robertson, Sarah A.

“…Abstract STUDY QUESTION Do seminal plasma transforming growth factor-β (TGFB) cytokines vary within individuals over time, and does this relate to sperm…”
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Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells by Sharkey, David J., Macpherson, Anne M., Tremellen, Kelton P., Robertson, Sarah A.

“…Exposure to semen elicits an inflammatory response in the female reproductive tract of rodents and other animals. The nature and regulation of any similar…”
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Immune regulatory cytokines in seminal plasma of healthy men: A scoping review and analysis of variance by Lyons, Hannah E, Arman, Bridget M, Robertson, Sarah A, Sharkey, David J

“…Seminal plasma cytokines are associated with fertility and reproductive health, but progressing their clinical utility is hampered by absence of reference data…”
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surviveR: a flexible shiny application for patient survival analysis by Sessler, Tamas, Quinn, Gerard P., Wappett, Mark, Rogan, Emily, Sharkey, David, Ahmaderaghi, Baharak, Lawler, Mark, Longley, Daniel B., McDade, Simon S.

“…Kaplan–Meier (KM) survival analyses based on complex patient categorization due to the burgeoning volumes of genomic, molecular and phenotypic data, are an…”
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Toll-Like Receptor-4 Antagonist (+)-Naltrexone Protects Against Carbamyl-Platelet Activating Factor (cPAF)-Induced Preterm Labor in Mice by Wahid, Hanan H., Chin, Peck Yin, Sharkey, David J., Diener, Kerrilyn R., Hutchinson, Mark R., Rice, Kenner C., Moldenhauer, Lachlan M., Robertson, Sarah A.

“…Spontaneous preterm labor is frequently caused by an inflammatory response in the gestational tissues elicited by either infectious or sterile agents. In…”
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Interferon-gamma inhibits seminal plasma induction of colony-stimulating factor 2 in mouse and human reproductive tract epithelial cells by Sharkey, David J, Glynn, Danielle J, Schjenken, John E, Tremellen, Kelton P, Robertson, Sarah A

“…Seminal fluid interacts with the female reproductive tract to initiate a permissive immune response that facilitates embryo implantation and pregnancy success…”
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miRNA Regulation of Immune Tolerance in Early Pregnancy by Schjenken, John E., Zhang, Bihong, Chan, Hon Y., Sharkey, David J., Fullston, Tod, Robertson, Sarah A.

“…To support embryo implantation, the female reproductive tract must provide a tolerogenic immune environment. Seminal fluid contact at conception contributes to…”
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