Search Results - "Sharif, N. A."

Rho-Rho kinase pathway in the actomyosin contraction and cell-matrix adhesion in immortalized human trabecular meshwork cells by Ramachandran, C, Patil, R V, Combrink, K, Sharif, N A, Srinivas, S P

“…The outflow facility for aqueous humor across the trabecular meshwork (TM) is enhanced by agents that oppose the actomyosin contraction of its resident cells…”
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Pharmacological characterization of [3H]‐prostaglandin E2 binding to the cloned human EP4 prostanoid receptor by Davis, T L, Sharif, N A

“…Prostaglandin (PG) E2 (PGE2) is a potent prostanoid derived from arachidonic which can interact with EP1, EP2, EP3 and EP4 prostanoid receptor subtypes…”
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Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells by Sharif, N A, Kelly, C R, Crider, J Y, Williams, G W, Xu, S X

“…Natural prostaglandins (PGs) such as PGD2, PGE2, PGF2(2alpha), and PGI2 exhibited the highest affinity for their respective cognate receptors, but were the…”
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Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: pharmacological characterization using agonists and antagonists by Crider, J Y, Griffin, B W, Sharif, N A

“…Various prostaglandin agonists representing various classes of receptor subtypes were evaluated for their ability to stimulate adenylyl cyclase via the…”
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Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases by Sharif, N A, Xu, S X, Miller, S T, Gamache, D A, Yanni, J M

“…Olopatadine (AL-4943A; KW-4679) [(Z)-11-[3-(dimethylamino)propylidene]-6, 11-dihydrodibenz[b,e]oxepine-2-acetic acid hydrochloride] is an…”
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[3H]AL-5848 ([3H]9β-(+)-Fluprostenol). Carboxylic Acid of Travoprost (AL-6221), a Novel FP Prostaglandin o study the Pharmacology and Autoradiographic Localization of the FP Receptor by SHARIF, N. A., DAVIS, T. L., WILLIAMS, G. W.

“…AL‐5848 (5Z,13E)‐(9 S,11R,15S)‐9,11,15‐trihydroxy‐5,13‐prostadienoic acid) is the carboxylic acid of travoprost (AL‐6221), a single (+)‐isomer of…”
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Pharmacology and autoradiography of human DP prostanoid receptors using [3H]‐BWA868C, a DP receptor‐selective antagonist radioligand by Sharif, N A, Williams, G W, Davis, T L

“…A potent and highly selective DP prostanoid receptor antagonist radioligand, [3H]‐cyclohexyl‐N‐BWA868C…”
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Discrete mapping of brain Mu and delta opioid receptors using selective peptides: quantitative autoradiography, species differences and comparison with kappa receptors by Sharif, N A, Hughes, J

“…The opioid peptides, [3H]DAGO and [3H]DPDPE, bound to rat and guinea pig brain homogenates with a high, nanomolar affinity and to a high density of mu and…”
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FP prostaglandin receptors mediating inositol phosphates generation and calcium mobilization in Swiss 3T3 cells: a pharmacological study by Griffin, B W, Williams, G W, Crider, J Y, Sharif, N A

“…A detailed pharmacological characterization of the prostaglandin (PG) receptor coupled to phosphoinositide (PI) turnover and intracellular calcium mobilization…”
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Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor by Sharif, N A, Kelly, C R, Crider, J Y

“…We have determined the agonist activity of a number of natural prostaglandins and prostaglandin analogs at the FP prostaglandin receptor cloned from a human…”
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Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies by Offord, EA, Sharif, NA, Mace, K, Tromvoukis, Y, Spillare, EA, Avanti, O, Howe, WE, Pfeifer, AM

“…To develop a metabolically competent, human immortalized corneal epithelial cell line for use in toxicity and inflammation studies. Primary corneal epithelial…”
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Effects of bradykinin on signal transduction, cell proliferation, and cytokine, prostaglandin E2 and collagenase‐1 release from human corneal epithelial cells by Wiernas, T K., Davis, T L., Griffin, B W., Sharif, N A.

“…1 We recently demonstrated the presence of phospholipase C‐coupled bradykinin (BK) B2‐receptors in human primary and SV40 virus‐immortalized corneal epithelial…”
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Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist by Hellberg, M R, Sallee, V L, McLaughlin, M A, Sharif, N A, Desantis, L, Dean, T R, Zinke, P W

“…Travoprost is the isopropyl ester prodrug of a high affinity, selective FP prostaglandin full receptor agonist. In contrast to travoprost acid's high affinity…”
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Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes by Sharif, N A, Xu, S X, Crider, J Y, McLaughlin, M, Davis, T L

“…The pharmacological characteristics of levobetaxolol, a single active isomer of betaxolol, were determined and compared with activities of other…”
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Quantitative autoradiographic visualization and pharmacology of FP-prostaglandin receptors in human eyes using the novel phosphor-imaging technology by Davis, T L, Sharif, N A

“…Quantitative autoradiographic visualization of FP prostaglandin receptors was determined in postmortem human eye sections using [3H]PGF2alpha and the novel…”
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Endogenous EP4 prostaglandin receptors coupled positively to adenylyl cyclase in Chinese hamster ovary cells : pharmacological characterization by CRIDER, J. Y, GRIFFIN, B. W, SHARIF, N. A

“…The purpose of these studies was to investigate the pharmacology of E-series and selected prostaglandins of other classes on adenylyl cyclase activity in…”
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Topical formulations of novel angiostatic steroids inhibit rabbit corneal neovascularization by BenEzra, D, Griffin, BW, Maftzir, G, Sharif, NA, Clark, AF

“…To evaluate the antiangiogenic potential of topical ophthalmic formulations of the novel angiostatic steroids AL-3789 and AL-4940, using a rabbit model of…”
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AL-3138 Antagonizes FP Prostanoid Receptor-mediated Inositol Phosphates Generation: Comparison with Some Purported FP Antagonists by SHARIF, N. A., CRIDER, J. Y., DAVIS, T. L.

“…The aim of this study was to pharmacologically characterize the antagonist properties of a novel prostaglandin F2α (PGF2α) analogue (11‐deoxy‐16‐fluoro PGF2α;…”
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Binding affinities of ocular hypotensive beta-blockers levobetaxolol, levobunolol, and timolol at endogenous guinea pig beta-adrenoceptors by Sharif, N A, Xu, S X

“…The current study determined the relative affinities and selectivities of numerous beta-adrenoceptor antagonists at the endogenous beta(1)- and…”
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The expression of functionally‐coupled B2‐bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists by Wiernas, T. K., Griffin, B. W., Sharif, N. A.

“…Bradykinin (BK) and Lys‐BK are peptides which are released at high nanomolar concentrations into the tear‐film of ocular allergic patients. We hypothesized…”
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