CTHRC1 expression is a novel shared diagnostic and prognostic biomarker of survival in six different human cancer subtypes

According to the previous reports, the collagen triple helix repeat containing 1 (CTHRC1) causes tumorigenesis by modulating the tumor microenvironment, however, the evidence is limited to a few human cancer subtypes. In the current study, we analyzed and validated the CTHRC1 expression variations i...

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Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; pp. 19873 - 18
Main Authors:	Sial, Nuzhat, Ahmad, Mukhtiar, Hussain, Muhammad Safdar, Iqbal, Muhammad Junaid, Hameed, Yasir, Khan, Mehran, Abbas, Mustansar, Asif, Rizwan, Rehman, Jalil Ur, Atif, Muhammad, Khan, Muhammad Rashid, Hameed, Zahid, Saeed, Hina, Tanveer, Rida, Saeed, Saba, Sharif, Aneeqa, Asif, Hafiz Muhammad
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06-10-2021 Nature Publishing Group Nature Portfolio
Subjects:	631/114 631/61 631/67 631/80 Adenocarcinoma Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomarkers Biomarkers, Tumor Cancer CD8 antigen CD8-Positive T-Lymphocytes Collagen Computational Biology - methods Databases, Genetic Disease Susceptibility DNA Methylation Endometrial cancer Endometrium Epigenesis, Genetic Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Gene Expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Head and neck carcinoma Hepatocellular carcinoma Hepatocytes Humanities and Social Sciences Humans Immunohistochemistry Kaplan-Meier Estimate Lung cancer Lung carcinoma Metastases multidisciplinary Neoplasm Staging Neoplasms - diagnosis Neoplasms - genetics Neoplasms - mortality Neoplasms - therapy Organ Specificity Prognosis Promoter Regions, Genetic Protein Interaction Mapping Renal cell carcinoma Science Science (multidisciplinary) Squamous cell carcinoma Tumor microenvironment Tumorigenesis Uterine cancer Uterus
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Summary:	According to the previous reports, the collagen triple helix repeat containing 1 (CTHRC1) causes tumorigenesis by modulating the tumor microenvironment, however, the evidence is limited to a few human cancer subtypes. In the current study, we analyzed and validated the CTHRC1 expression variations in 24 different human cancer tissues paired with normal tissues using publically available databases. We observed that CTHRC1 was overexpressed in all the 24 major subtypes of human cancers and its overexpression was significantly associated with the reduced overall survival (OS) duration of head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), Lung adenocarcinoma (LUAD), stomach adenocarcinoma (STAD), and Uterine corpus endometrial carcinoma (UCEC). This implies that CTHRC1 plays a significant role in the development and progression of these cancers. We further noticed that CTHRC1 was also overexpressed in HNSC, KIRC, LIHC, LUAD, STAD, and UCEC patients of different clinicopathological features. Pathways enrichment analysis revealed the involvement of CTHRC1 associated genes in seven diverse pathways. We also explored few interesting correlations between CTHRC1 expression and promoter methylation, genetic alterations, CNVs, CD8+ T immune cells infiltration, and tumor purity. In conclusion, CTHRC1 can serve as a shared diagnostic and prognostic biomarker in HNSC, KIRC, LIHC, LUAD, STAD, and UCEC patients of different clinicopathological features.
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-99321-w