Search Results - "Sharief, M K"

Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit by SILBER, E, SEMRA, Y. K, GREGSON, N. A, SHARIEF, M. K

“…The cause of axonal loss, an important contributor to disability in MS, is poorly understood. This study investigated whether progression in MS is associated…”
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Infection-associated encephalopathies : their investigation, diagnosis, and treatment by DAVIES, Nicholas W. S, SHARIEF, Mohammad K, HOWARD, Robin S

“…Reduced level of consciousness is a common clinical finding in acutely sick patients. In the majority of cases a cause for the encephalopathy is readily…”
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Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis by Sharief, Mohammad K, Hentges, Romain

“…MULTIPLE sclerosis, an inflammatory and demyelinating disease of the central nervous system, is regarded as a major cause of neurologic disability among young…”
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A double blind, randomised study of sildenafil citrate for erectile dysfunction in men with multiple sclerosis by Fowler, C J, Miller, J R, Sharief, M K, Hussain, I F, Stecher, V J, Sweeney, M

“…Objective: Identifying and effectively treating erectile dysfunction (ED) can result in an improvement of the quality of life (QoL) in men with multiple…”
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Factors influencing PCR detection of viruses in cerebrospinal fluid of patients with suspected CNS infections by Davies, N W S, Brown, L J, Gonde, J, Irish, D, Robinson, R O, Swan, A V, Banatvala, J, Howard, R S, Sharief, M K, Muir, P

“…Background: Polymerase chain reaction (PCR) is used to detect viruses in the cerebrospinal fluid (CSF) of patients with neurological disease. However, data to…”
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IV immunoglobulin reduces circulating proinflammatory cytokines in Guillain-Barré syndrome by SHARIEF, M. K, INGRAM, D. A, SWASH, M, THOMPSON, E. J

“…Treatment with human i.v. immunoglobulin (IVIg) modifies the course of Guillain-Barré syndrome (GBS), but its specific mode of action is unknown. Cellular…”
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Neurophysiologic analysis of neuromuscular symptoms in UK Gulf War veterans: A controlled study by SHARIEF, M. K, PRIDDIN, J, DELAMONT, R. S, UNWIN, C, ROSE, M. R, DAVID, A, WESSELY, S

“…UK veterans who were deployed to the Gulf in 1990 to 1991 reported higher prevalence of neuromuscular symptoms. To investigate whether these Gulf War-related…”
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Axonal ion channel dysfunction in amyotrophic lateral sclerosis by Bostock, H, Sharief, M K, Reid, G, Murray, N M

“…In amyotrophic lateral sclerosis (ALS) it is not known how or why the motor neurons die, but a clue is provided by observations that the dying cells discharge…”
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Hypocretin (orexin) deficiency in narcolepsy and primary hypersomnia by Ebrahim, I O, Sharief, M K, de Lacy, S, Semra, Y K, Howard, R S, Kopelman, M D, Williams, A J

“…The discovery that hypocretins are involved in narcolepsy, a disorder associated with excessive daytime sleepiness, cataplexy, and unusually rapid transitions…”
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Heightened intrathecal release of axonal cytoskeletal proteins in multiple sclerosis is associated with progressive disease and clinical disability by Semra, Y.K, Seidi, O.A, Sharief, M.K

“…The pathologic basis of disease progression in multiple sclerosis (MS) is thought to involve axonal degeneration, which contributes to the accumulation of…”
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Heightened intrathecal release of soluble CD137 in patients with multiple sclerosis by Sharief, M. K.

“…Human CD137 (ILA/4‐1BB), a member of the tumour necrosis factor (TNF) receptor family, regulates the activation and proliferation of immune cells, and may…”
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PUFA in the pathogenesis and treatment of patients with multiple sclerosis by Harbige, L. S., Pinto, E., Xiang, M., Leach, M., Sharief, M. K.

“…Cytokine dysregulation has been found in peripheral blood mononuclear cells (PBMC) during the relapse-remitting phases of MS, i.e. raised TNFα and IL-1β and…”
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Axonal degeneration in the pathogenesis of multiple sclerosis by Silber, Eli, Sharief, Mohammad K

“…Axonal degeneration plays an important role in the accumulation of disability in patients with multiple sclerosis (MS). Pathological studies have demonstrated…”
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Evaluation of neuromuscular symptoms in uk Gulf War veterans: A controlled study by ROSE, M. R, SHARIEF, M. K, WESSELY, S, PRIDDIN, J, NIKOLAOU, V, HULL, L, UNWIN, C, AJMAL-ALI, R, SHERWOOD, R. A, SPELLMAN, A, DAVID, A

“…To determine whether Gulf War veterans with neuromuscular symptoms that included weakness and fatigue had either 1) objective correlates for muscle weakness or…”
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Elevated serum levels of tumor necrosis factor-alpha in Guillain-Barré syndrome by Sharief, M K, McLean, B, Thompson, E J

“…Activated T lymphocytes and macrophages play a putative role in the the pathogenesis of Guillain-Barré syndrome. Both cell types secrete tumor necrosis…”
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Impaired Fas-independent apoptosis of T lymphocytes in patients with multiple sclerosis by Sharief, M.K

“…The homeostasis of the immune system is maintained by apoptotic (programmed cell death) elimination of potentially pathogenic, autoreactive mononuclear cells…”
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Blood-Brain Barrier Damage in Patients with Bacterial Meningitis: Association with Tumor Necrosis Factor-α but Not Interleukin-1β by Sharief, M. K., Ciardi, M., Thompson, E. J.

“…Brain damage after meningeal infection could result from impairment of cerebral endothelial cell functions and disruption of blood-brain barriers. Tumor…”
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In vivo relationship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis by Sharief, M K, Thompson, E J

“…Tumor necrosis factor-alpha (TNF-alpha) has well recognized effects on cerebral endothelial cells and, therefore, may mediate disruption of blood-brain barrier…”
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Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-alpha and blood-brain barrier damage by Sharief, M K, Noori, M A, Ciardi, M, Cirelli, A, Thompson, E J

“…The mechanism for the initiation of blood-brain barrier damage and intrathecal inflammation in multiple sclerosis (MS) is poorly understood. We have recently…”
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Overexpression of the apoptosis inhibitor FLIP in T cells correlates with disease activity in multiple sclerosis by Semra, Y.K, Seidi, O.A, Sharief, M.K

“…The cellular caspase-inhibitory protein FLIP has been recently identified as a potent regulator of T lymphocyte susceptibility to Fas-mediated programmed cell…”
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