Search Results - "Shariat‐Madar, Z"

Human plasma kallikrein-kinin system: physiological and biochemical parameters by Bryant, J W, Shariat-Madar, Z

“…The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS encompasses coagulation factor XII (FXII), the complex of…”
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Prolylcarboxypeptidase independently activates plasma prekallikrein (fletcher factor) by Wang, J, Matafonov, A, Madkhali, H, Mahdi, F, Watson, D, Schmaier, A H, Gailani, D, Shariat-Madar, Z

“…Prolylcarboxypeptidase isoform 1 (PRCP1) is capable of regulating numerous autocrines and hormones, such as angiotensin II, angiotensin III, αMSH1-13, and…”
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Biochemical characterization of a novel high‐affinity and specific plasma kallikrein inhibitor by Kolte, D, Bryant, JW, Holsworth, D, Wang, J, Akbari, P, Gibson, GW, Shariat‐Madar, Z

“…BACKGROUND AND PURPOSE Kallikrein acts on high molecular weight kininogen (HK) to generate HKa (cleaved HK) and bradykinin (BK). BK exerts its effects by…”
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Influence of a novel inhibitor (UM8190) of prolylcarboxypeptidase (PRCP) on appetite and thrombosis by Rabey, F M, Gadepalli, R S V S, Diano, S, Cheng, Q, Tabrizian, T, Gailani, D, Rimoldi, J M, Shariat-Madar, Z

“…Preclinical pharmacological characterization of a novel inhibitor (UM8190) of prolylcarboxypeptidase (PRCP) was investigated. We synthesized and evaluated a…”
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Prolylcarboxypeptidase (PRCP) as a new target for obesity treatment by Shariat-Madar, B, Kolte, D, Verlangieri, A, Shariat-Madar, Z

“…Recently, we serendipitously discovered that mice with the deficiency of the enzyme prolylcarboxypeptidase (PRCP) have elevated alpha-melanocyte-stimulating…”
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PF-04886847 (an inhibitor of plasma kallikrein) attenuates inflammatory mediators and activation of blood coagulation in rat model of lipopolysaccharide (LPS)-induced sepsis by Kolte, D, Bryant, J W, Gibson, G W, Wang, J, Shariat-Madar, Z

“…The plasma kallikrein-mediated proteolysis regulates both thrombosis and inflammation. Previous study has shown that PF-04886847 is a potent and competitive…”
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Prolylcarboxypeptidase: A cardioprotective enzyme by Mallela, J., Yang, J., Shariat-Madar, Z.

“…Prolylcarboxypeptidase (PRCP) is involved in regulating the blood flow through active tissues in order to preserve the internal environment. The expression of…”
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Assembly of high molecular weight kininogen and activation of prekallikrein on cell matrix by Motta, G, Shariat-Madar, Z, Mahdi, F, Sampaio, C A, Schmaier, A H

“…Investigations determined if extracellular matrix of endothelial cells (EC) is a platform for HK assembly and PK activation. In buffers containing bovine serum…”
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Highly selective hydrolysis of kinins by recombinant prolylcarboxypeptidase by Chajkowski, S.M., Mallela, J., Watson, D.E., Wang, J., McCurdy, C.R., Rimoldi, J.M., Shariat-Madar, Z.

“…► The kinetic parameters of the kinin hydrolysis reaction by LC–MS. ► The correlation between K M and k cat values and the substrate structure. ► The IC 50 for…”
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Identification of lipopolysaccharide binding site on high molecular weight kininogen by Perkins, R., Ngo, M. Dinh, Mahdi, F., Shariat-Madar, Z.

“…Plasma kallikrein kinin system (KKS) activation along with its cellular receptors expression are increased after injury and in patients with septic shock,…”
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Overexpression of prolylcarboxypeptidase enhances plasma prekallikrein activation on Chinese hamster ovary cells by Shariat-Madar, Z, Rahimy, E, Mahdi, F, Schmaier, A H

“…Plasma prekallikrein (PK) complexes with its receptor, high-molecular-weight kininogen (HK), on human umbilical vein endothelial cells (HUVEC). When assembled…”
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Cytosolic Calmodulin Is Increased in SK‐N‐SH Human Neuroblastoma Cells Due to Release of Calcium from Intracellular Stores by McGinnis, K. M., Shariat‐Madar, Z., Gnegy, M. E.

“…: Muscarinic receptor stimulation elicits a redistribution of calmodulin (CaM) from the membrane fraction to cytosol in the human neuroblastoma cell line…”
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The functional importance of the N-terminal region of human prolylcarboxypeptidase by Mallela, J., Perkins, R., Yang, J., Pedigo, S., Rimoldi, J.M., Shariat-Madar, Z.

“…The renin–angiotensin-system cascade pathway generates the vasopressor and prothrombotic hormones, angiotensin II (Ang II) and angiotensin III (Ang III) from…”
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Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells by Mahdi, Fakhri, Shariat-Madar, Zia, Todd, Robert F., Figueroa, Carlos D., Schmaier, Alvin H.

“…The cellular localization of human cytokeratin 1 (CK1), urokinase plasminogen activator receptor (uPAR), and gC1qR, high-molecular-weight kininogen…”
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Effect of Continuous Phorbol Ester Treatment on Muscarinic Receptor‐Mediated Calmodulin Redistribution in SK‐N‐SH Neuroblastoma Cells by Shariat‐Madar, Z., Goldsmith, A. M., Gnegy, M. E.

“…: Stimulation of muscarinic receptors by carbachol and activation of protein kinase C elicits the translocation of calmodulin (CaM) from membranes to cytosol…”
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Factor XI assembly and activation on human umbilical vein endothelial cells in culture by Shariat-Madar, Z, Mahdi, F, Schmaier, A H

“…Biotin-FXI optimally bound to HUVEC in the presence of 40 nM high molecular weight kininogen (HK) and > or =7 microM Zn2+. There was little specific FXI…”
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Reconstitution, identification, purification, and immunological characterization of the 110-kDa Na+/Ca2+ antiporter from beef heart mitochondria by Li, W, Shariat-Madar, Z, Powers, M, Sun, X, Lane, R D, Garlid, K D

“…The mitochondrial Na+/Ca2+ antiporter plays a key role in the physiological regulation of intramitochondrial Ca2+, which in turn attunes mitochondrial enzymes…”
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Identification and Characterization of Prolylcarboxypeptidase as an Endothelial Cell Prekallikrein Activator by Shariat-Madar, Zia, Mahdi, Fakhri, Schmaier, Alvin H.

“…Our recent investigations have postulated a human umbilical vein endothelial cell (HUVEC)-associated prekallikrein activator (PKA). When prekallikrein (PK)…”
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Recombinant prolylcarboxypeptidase activates plasma prekallikrein by Shariat-Madar, Zia, Mahdi, Fakhri, Schmaier, Alvin H.

“…The serine protease prolylcarboxypeptidase (PRCP), isolated from human umbilical vein endothelial cells (HUVECs), is a plasma prekallikrein (PK) activator…”
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Reconstitution and partial purification of the Na(+)-selective Na+/H+ antiporter of beef heart mitochondria by Garlid, K D, Shariat-Madar, Z, Nath, S, Jezek, P

“…Na+/H+ antiporters play important physiological roles in most biological membranes. Although they were first discovered in mitochondria (Mitchell, P., and…”
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