Search Results - "Sharfstein, Susan T"

Heparin: Past, Present, and Future by Oduah, Eziafa I, Linhardt, Robert J, Sharfstein, Susan T

“…Heparin, the most widely used anticoagulant drug in the world today, remains an animal-derived product with the attendant risks of adulteration and…”
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An 'omics approach towards CHO cell engineering by Datta, Payel, Linhardt, Robert J., Sharfstein, Susan T.

“…Chinese hamster ovarian cells (CHO) cells have been extensively utilized for industrial production of biopharmaceutical products, such as monoclonal…”
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Proteasome inhibition paradoxically degrades gain-of-function mutant p53 R273H in NSCLC and could have therapeutic implications by Oduah, Eziafa I, Sharfstein, Susan T, Seetharamu, Nagashree, Grossman, Steven R, Litovchick, Larisa

“…Lung cancer is the leading cause of cancer mortality. Despite therapeutic advances in recent years, new treatment strategies are needed to improve outcomes of…”
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TGFβ2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor by Torrejon, Karen Y., Papke, Ellen L., Halman, Justin R., Bergkvist, Magnus, Danias, John, Sharfstein, Susan T., Xie, Yubing

“…Members of the transforming growth factor beta (TGFβ) cytokine family have long been associated with affecting several cellular functions, including cell…”
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Salivary Gland Bioengineering by Rose, Stephen C, Larsen, Melinda, Xie, Yubing, Sharfstein, Susan T

“…Salivary gland dysfunction affects millions globally, and tissue engineering may provide a promising therapeutic avenue. This review delves into the current…”
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Alginate Hydrogel Microtubes for Salivary Gland Cell Organization and Cavitation by Jorgensen, Matthew, Ramesh, Pujhitha, Toro, Miriam, Evans, Emily, Moskwa, Nicholas, Zhang, Xulang, Sharfstein, Susan T, Larsen, Melinda, Xie, Yubing

“…Understanding the different regulatory functions of epithelial and mesenchymal cell types in salivary gland development and cellular organization is essential…”
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Bio-hybrid electronic and photonic devices by Sharfstein, Susan T

“…Bio-hybrid devices, combining electronic and photonic components with cells, tissues, and organs, hold potential for advancing our understanding of biology,…”
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Evaluation of Alginate Hydrogel Microstrands for Stromal Cell Encapsulation and Maintenance by Kollampally, Sujith Chander Reddy, Zhang, Xulang, Moskwa, Nicholas, Nelson, Deirdre A, Sharfstein, Susan T, Larsen, Melinda, Xie, Yubing

“…Mesenchymal stromal cells (MSCs) have displayed potential in regenerating organ function due to their anti-fibrotic, anti-inflammatory, and regenerative…”
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Recreating the Trabecular Outflow Tissue on Implantable, Micropatterned, Ultrathin, Porous Polycaprolactone Scaffolds by Beardslee, Luke A, Halman, Justin R, Unser, Andrea M, Xie, Yubing, Danias, John, Bergkvist, Magnus, Sharfstein, Susan T, Torrejon, Karen Y

“…Glaucoma, where increased intraocular pressure (IOP) leads to damage to the optic nerve and loss of sight, is amongst the foremost causes of irreversible…”
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Non-protein biologic therapeutics by Sharfstein, Susan T

“…[Display omitted] •Peptide, nucleic acid, carbohydrate, viral, and cell-based therapies are reviewed.•Recent advances and approvals in the last two years are…”
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Optimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin by Baik, Jong Youn, Dahodwala, Hussain, Oduah, Eziafa, Talman, Lee, Gemmill, Trent R., Gasimli, Leyla, Datta, Payel, Yang, Bo, Li, Guoyun, Zhang, Fuming, Li, Lingyun, Linhardt, Robert J., Campbell, Andrew M., Gorfien, Stephen F., Sharfstein, Susan T.

“…Heparin is the most widely used anticoagulant drug in the world today. Heparin is currently produced from animal tissues, primarily porcine intestines. A…”
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effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells by Nam, Jong Hyun, Zhang, Fuming, Ermonval, Myriam, Linhardt, Robert J, Sharfstein, Susan T

“…The effects of different culture conditions, suspension and microcarrier culture and temperature reduction on the structures of N-linked glycans attached to…”
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Transcriptomic responses to sodium chloride-induced osmotic stress: A study of industrial fed-batch CHO cell cultures by Shen, Duan, Kiehl, Thomas R., Khattak, Sarwat F., Li, Zheng Jian, He, Aiqing, Kayne, Paul S., Patel, Vishal, Neuhaus, Isaac M., Sharfstein, Susan T.

“…The rapidly expanding market for monoclonal antibody and Fc‐fusion‐protein therapeutics has increased interest in improving the productivity of mammalian cell…”
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Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter by Dahodwala, Hussain, Kaushik, Prashant, Tejwani, Vijay, Kuo, Chih-Chung, Menard, Patrice, Henry, Michael, Voldborg, Bjorn G., Lewis, Nathan E., Meleady, Paula, Sharfstein, Susan T.

“…Most therapeutic monoclonal antibodies in biopharmaceutical processes are produced in Chinese hamster ovary (CHO) cells. Technological advances have rendered…”
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A Closer Look at Schlemm's Canal Cell Physiology: Implications for Biomimetics by Dautriche, Cula N, Tian, Yangzi, Xie, Yubing, Sharfstein, Susan T

“…Among ocular pathologies, glaucoma is the second leading cause of progressive vision loss, expected to affect 80 million people worldwide by 2020. A primary…”
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High‐throughput and automation advances for accelerating single‐cell cloning, monoclonality and early phase clone screening steps in mammalian cell line development for biologics production by Tejwani, Vijay, Chaudhari, Minal, Rai, Toyaj, Sharfstein, Susan T.

“…Mammalian cell line development is a multistep process wherein timelines for developing clonal cells to be used as manufacturing cell lines for biologics…”
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Reduced Culture Temperature Differentially Affects Expression and Biophysical Properties of Monoclonal Antibody Variants by Mason, Megan, Sweeney, Bernadette, Cain, Katharine, Stephens, Paul, Sharfstein, Susan

“…Reduced culture temperature is an increasingly popular practice to improve recombinant protein yields in CHO cells. Recent studies have attributed the…”
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The 'Omics Revolution in CHO Biology: Roadmap to Improved CHO Productivity by Dahodwala, Hussain, Sharfstein, Susan T

“…Chinese hamster ovary (CHO) cell physiology understanding has advanced very rapidly in the past few years with incredible improvements in long-read sequencing,…”
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Glycoengineering in CHO Cells: Advances in Systems Biology by Tejwani, Vijay, Andersen, Mikael R., Nam, Jong Hyun, Sharfstein, Susan T.

“…For several decades, glycoprotein biologics have been successfully produced from Chinese hamster ovary (CHO) cells. The therapeutic efficacy and potency of…”
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Microarray platform affords improved product analysis in mammalian cell growth studies by Datta, Payel, Meli, Luciana, Li, Lingyun, Migliore, Nicole, Schaefer, Eugene, Sharfstein, Susan T., Dordick, Jonathan S., Linhardt, Robert J.

“…High throughput (HT) platforms serve as a cost‐efficient and rapid screening method for evaluating the effect of cell‐culture conditions and screening of…”
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