Search Results - "Sharer, J E"

Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey by Sharer, J E, Shipley, L A, Vandenbranden, M R, Binkley, S N, Wrighton, S A

“…The metabolism of probe substrates of phase I and phase II enzymes in vitro were compared in hepatic subcellular fractions from humans, cynomolgus monkeys,…”
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Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine by Sharer, J E, Wrighton, S A

“…Antipyrine biotransformation has been used extensively in clinical studies as a marker for general hepatic oxidative or cytochrome P450 (P450)-mediated,…”
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Species and tissue differences in the microsomal oxidation of 1,3-butadiene and the glutathione conjugation of butadiene monoxide in mice and rats. Possible role in 1,3-butadiene-induced toxicity by Sharer, J E, Duescher, R J, Elfarra, A A

“…Rat and mouse liver, lung, and kidney microsomes metabolized 1,3-butadiene to butadiene monoxide (BM), whereas microsomes from testis, one of the target organs…”
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Epoxide Hydrolase-Dependent Metabolism of Butadiene Monoxide to 3-Butene-1,2-diol in Mouse, Rat, and Human Liver by KRAUSE, R. J, SHARER, J. E, ELFARRA, A. A

“…Incubations of butadiene monoxide (BMO) with mouse, rat, and human liver microsomes or cDNA-expressed human microsomal epoxide hydrolase led to…”
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Formation, stability, and rearrangements of the glutathione conjugates of butadiene monoxide: evidence for the formation of stable sulfurane intermediates by Sharer, Jane E, Duescher, Renee J, Elfarra, Adnan A

“…Butadiene monoxide, a toxic metabolite of 1,3-butadiene, is a substrate for the human placental glutathione (GSH) S-transferase. The products have been…”
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Synthesis and Characterization of N-Acetyl-L-cysteine S-Conjugates of Butadiene Monoxide and Their Detection and Quantitation in Urine of Rats and Mice Given Butadiene Monoxide by Elfarra, Adnan A, Sharer, Jane E, Duescher, Renee J

“…Butadiene monoxide (BM), a mutagen and carcinogen, is the major metabolite of 1,3-butadiene in rats and mice. Because mercapturic acids (N-acetyl-L-cysteine…”
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Reviewing Acid-Base Balance by Sharer, Jo Ellen

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S-(2-hydroxy-3-buten-1-y)glutathione and S-(1-hydroxy-3-buten-2-yl)glutathione are in vivo metabolites of butadienes monoxide : detection and quantitation in bile by SHARER, J. E, ELFARRA, A. A

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S-(2-Hydroxy-3-buten-1-yl)glutathione and S-(1-hydroxy-3-buten-2-yl)glutathione are in vivo metabolites of butadiene monoxide: detection and quantitation in bile by Sharer, Jane E, Elfarra, Adnan A

“…Administration (ip) of butadiene monoxide, a toxic metabolite of 1,3-butadiene, to rats caused the appearance of two new biliary peaks when analyzed by HPLC…”
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