Search Results - "Shapovalova, Irina V."

Modeling the Structure of Human tRNA-Guanine Transglycosylase in Complex with 7-Methylguanine and Revealing the Factors that Determine the Enzyme Interaction with Inhibitors by Pushkarev, Sergey V., Vinnik, Valeriia A., Shapovalova, Irina V., Švedas, Vytas K., Nilov, Dmitry K.

“…tRNA-guanine transglycosylase, an enzyme catalyzing replacement of guanine with queuine in human tRNA and participating in the translation mechanism, is…”
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Molecular modeling of different substrate‐binding modes and their role in penicillin acylase catalysis by Novikov, Fedor N., Stroganov, Oleg V., Khaliullin, Ilyas G., Panin, Nikolay V., Shapovalova, Irina V., Chilov, Ghermes G., Švedas, Vytas K.

“…Molecular modeling was addressed to understand different substrate‐binding modes and clarify the role of two positively charged residues of the penicillin G…”
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Saturation mutagenesis reveals the importance of residues αR145 and αF146 of penicillin acylase in the synthesis of β-lactam antibiotics by Jager, Simon A.W., Shapovalova, Irina V., Jekel, Peter A., Alkema, Wynand B.L., Švedas, Vytas K., Janssen, Dick B.

“…Penicillin acylase (PA) from Escherichia coli can catalyze the coupling of an acyl group to penicillin- and cephalosporin-derived β-lactam nuclei, a conversion…”
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The βD484N mutant of penicillin acylase from Escherichia coli is more resistant to inactivation by substrates and can effectively perform peptide synthesis in aqueous medium by Shcherbakova, Tatyana A., Panin, Nikolay V., Suplatov, Dmitry A., Shapovalova, Irina V., Švedas, Vytas K.

“…•Penicillin acylase has been stabilized to substrate inactivation by single mutation.•Penicillin acylase mutant βD484N can effectively catalyze peptide…”
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Saturation mutagenesis reveals the importance of residues alphaR145 and alphaF146 of penicillin acylase in the synthesis of beta-lactam antibiotics by Jager, Simon A W, Shapovalova, Irina V, Jekel, Peter A, Alkema, Wynand B L, Svedas, Vytas K, Janssen, Dick B

“…Penicillin acylase (PA) from Escherichia coli can catalyze the coupling of an acyl group to penicillin- and cephalosporin-derived beta-lactam nuclei, a…”
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