Search Results - "Shapiro, Roger"

Neural-Tube Defects with Dolutegravir Treatment from the Time of Conception by Zash, Rebecca, Makhema, Joseph, Shapiro, Roger L

“…Preventing mother-to-child transmission of HIV is a priority, but assessing a medication for potential side effects in pregnancy is complicated. In this…”
Get full text

Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana by Zash, Rebecca, Holmes, Lewis, Diseko, Modiegi, Jacobson, Denise L, Brummel, Sean, Mayondi, Gloria, Isaacson, Arielle, Davey, Sonya, Mabuta, Judith, Mmalane, Mompati, Gaolathe, Tendani, Essex, M, Lockman, Shahin, Makhema, Joseph, Shapiro, Roger L

“…In the context of increasing treatment for HIV infection in Botswana, an association between dolutegravir use and neural-tube defects was identified…”
Get full text

Comparative Safety of Antiretroviral Treatment Regimens in Pregnancy by Zash, Rebecca, Jacobson, Denise L, Diseko, Modiegi, Mayondi, Gloria, Mmalane, Mompati, Essex, Max, Petlo, Chipo, Lockman, Shahin, Makhema, Joseph, Shapiro, Roger L

“…Maternal antiretroviral treatment (ART) started before conception may increase the risk for adverse birth outcomes among women with human immunodeficiency…”
Get more information

Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa by Viana, Raquel, Moyo, Sikhulile, Amoako, Daniel G., Tegally, Houriiyah, Scheepers, Cathrine, Althaus, Christian L., Anyaneji, Ugochukwu J., Bester, Phillip A., Boni, Maciej F., Chand, Mohammed, Choga, Wonderful T., Colquhoun, Rachel, Davids, Michaela, Deforche, Koen, Doolabh, Deelan, du Plessis, Louis, Engelbrecht, Susan, Everatt, Josie, Giandhari, Jennifer, Giovanetti, Marta, Hardie, Diana, Hill, Verity, Hsiao, Nei-Yuan, Iranzadeh, Arash, Ismail, Arshad, Joseph, Charity, Joseph, Rageema, Koopile, Legodile, Kosakovsky Pond, Sergei L., Kraemer, Moritz U. G., Kuate-Lere, Lesego, Laguda-Akingba, Oluwakemi, Lesetedi-Mafoko, Onalethatha, Lessells, Richard J., Lockman, Shahin, Lucaci, Alexander G., Maharaj, Arisha, Mahlangu, Boitshoko, Maponga, Tongai, Mahlakwane, Kamela, Makatini, Zinhle, Marais, Gert, Maruapula, Dorcas, Masupu, Kereng, Matshaba, Mogomotsi, Mayaphi, Simnikiwe, Mbhele, Nokuzola, Mbulawa, Mpaphi B., Mendes, Adriano, Mlisana, Koleka, Mnguni, Anele, Mohale, Thabo, Moir, Monika, Moruisi, Kgomotso, Mosepele, Mosepele, Motsatsi, Gerald, Motswaledi, Modisa S., Mphoyakgosi, Thongbotho, Msomi, Nokukhanya, Mwangi, Peter N., Naidoo, Yeshnee, Ntuli, Noxolo, Nyaga, Martin, Olubayo, Lucier, Pillay, Sureshnee, Radibe, Botshelo, Ramphal, Yajna, Ramphal, Upasana, San, James E., Scott, Lesley, Shapiro, Roger, Singh, Lavanya, Smith-Lawrence, Pamela, Stevens, Wendy, Strydom, Amy, Subramoney, Kathleen, Tebeila, Naume, Tshiabuila, Derek, Tsui, Joseph, van Wyk, Stephanie, Weaver, Steven, Wibmer, Constantinos K., Wilkinson, Eduan, Wolter, Nicole, Zarebski, Alexander E., Zuze, Boitumelo, Goedhals, Dominique, Preiser, Wolfgang, Treurnicht, Florette, Venter, Marietje, Williamson, Carolyn, Pybus, Oliver G., Bhiman, Jinal, Glass, Allison, Martin, Darren P., Rambaut, Andrew, Gaseitsiwe, Simani, von Gottberg, Anne, de Oliveira, Tulio

“…The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while…”
Get full text

Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19 by Stephenson, Kathryn E, Le Gars, Mathieu, Sadoff, Jerald, de Groot, Anne Marit, Heerwegh, Dirk, Truyers, Carla, Atyeo, Caroline, Loos, Carolin, Chandrashekar, Abishek, McMahan, Katherine, Tostanoski, Lisa H, Yu, Jingyou, Gebre, Makda S, Jacob-Dolan, Catherine, Li, Zhenfeng, Patel, Shivani, Peter, Lauren, Liu, Jinyan, Borducchi, Erica N, Nkolola, Joseph P, Souza, Morgana, Tan, Chen Sabrina, Zash, Rebecca, Julg, Boris, Nathavitharana, Ruvandhi R, Shapiro, Roger L, Azim, Ahmed Abdul, Alonso, Carolyn D, Jaegle, Kate, Ansel, Jessica L, Kanjilal, Diane G, Guiney, Caitlin J, Bradshaw, Connor, Tyler, Anna, Makoni, Tatenda, Yanosick, Katherine E, Seaman, Michael S, Lauffenburger, Douglas A, Alter, Galit, Struyf, Frank, Douoguih, Macaya, Van Hoof, Johan, Schuitemaker, Hanneke, Barouch, Dan H

“…IMPORTANCE: Control of the global COVID-19 pandemic will require the development and deployment of safe and effective vaccines. OBJECTIVE: To evaluate the…”
Get full text

Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2010/VESTED): a multicentre, open-label, randomised, controlled, phase 3 trial by Lockman, Shahin, Brummel, Sean S, Ziemba, Lauren, Stranix-Chibanda, Lynda, McCarthy, Katie, Coletti, Anne, Jean-Philippe, Patrick, Johnston, Ben, Krotje, Chelsea, Fairlie, Lee, Hoffman, Risa M, Sax, Paul E, Moyo, Sikhulile, Chakhtoura, Nahida, Stringer, Jeffrey SA, Masheto, Gaerolwe, Korutaro, Violet, Cassim, Haseena, Mmbaga, Blandina T, João, Esau, Hanley, Sherika, Purdue, Lynette, Holmes, Lewis B, Momper, Jeremiah D, Shapiro, Roger L, Thoofer, Navdeep K, Rooney, James F, Frenkel, Lisa M, Amico, K Rivet, Chinula, Lameck, Currier, Judith, Best, Brookie M., Blanchette, Cheryl, Browning, Renee, Cheng, Yao, Fox, Andee, Jaliaah, Nagawa, Knowles, Kevin, Mirochnick, Mark, Murtaugh, William A., Patras, Emmanuel, Pinilla, Mauricio, van Wyk, Jean, Whalen, Frances

“…Antiretroviral therapy (ART) during pregnancy is important for both maternal health and prevention of perinatal HIV-1 transmission; however adequate data on…”
Get full text

In-utero triple antiretroviral exposure associated with decreased growth among HIV-exposed uninfected infants in Botswana by Powis, Kathleen M, Smeaton, Laura, Hughes, Michael D, Tumbare, Esther A, Souda, Sajini, Jao, Jennifer, Wirth, Kathleen E, Makhema, Joseph, Lockman, Shahin, Fawzi, Wafaie, Essex, Max, Shapiro, Roger L

“…OBJECTIVE:To assess associations between in-utero triple antiretrovirals (cART) versus zidovudine (ZDV) monotherapy exposure and growth among HIV-uninfected…”
Get full text

Association of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection With Maternal Mortality and Neonatal Birth Outcomes in Botswana by Human Immunodeficiency Virus Status by Jackson-Gibson, Maya, Diseko, Modiegi, Caniglia, Ellen C, Mayondi, Gloria K, Mabuta, Judith, Luckett, Rebecca, Moyo, Sikhulile, Lawrence, Pamela, Matshaba, Mogomotsi, Mosepele, Mosepele, Mmalane, Mompati, Banga, Jaspreet, Lockman, Shahin, Makhema, Joseph, Zash, Rebecca, Shapiro, Roger L

“…To evaluate the combined association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human immunodeficiency virus (HIV) infection on…”
Get full text

Comparative safety of dolutegravir-based or efavirenz-based antiretroviral treatment started during pregnancy in Botswana: an observational study by Zash, Rebecca, Jacobson, Denise L, Diseko, Modiegi, Mayondi, Gloria, Mmalane, Mompati, Essex, Max, Gaolethe, Tendani, Petlo, Chipo, Lockman, Shahin, Holmes, Lewis B, Makhema, Joseph, Shapiro, Roger L

“…Global rollout of dolutegravir-based antiretroviral therapy (ART) has been hampered in part by insufficient safety data in pregnancy. We compared birth…”
Get full text

Highly Active Antiretroviral Therapy and Adverse Birth Outcomes Among HIV-infected Women in Botswana by Chen, Jennifer Y., Ribaudo, Heather J., Souda, Sajini, Parekh, Natasha, Ogwu, Anthony, Lockman, Shahin, Powis, Kathleen, Dryden-Peterson, Scott, Creek, Tracy, Jimbo, William, Madidimalo, Tebogo, Makhema, Joseph, Essex, Max, Shapiro, Roger L

“…Background. It is unknown whether adverse birth outcomes are associated with maternal highly active antiretroviral therapy (HAART) in pregnancy, particularly…”
Get full text

Increased Risk of Preterm Delivery Among HIV-Infected Women Randomized to Protease Versus Nucleoside Reverse Transcriptase Inhibitor-Based HAART During Pregnancy by Powis, Kathleen M., Kitch, Douglas, Ogwu, Anthony, Hughes, Michael D., Lockman, Shahin, Leidner, Jean, van Widenfelt, Erik, Moffat, Claire, Moyo, Sikhulile, Makhema, Joseph, Essex, Max, Shapiro, Roger L.

“…Background. Protease inhibitor (PI)-based highly active antiretro viral therapy (HAART) use in pregnancy has been associated with preterm deliveries in some…”
Get full text

Prolonged Cotrimoxazole Prophylaxis Has No Impact on Child Growth in the First Two Years of Life: Findings from a Randomized Controlled Trial in Botswana by Mussa, Aamirah, Powis, Kathleen M., Lockman, Shahin, Ajibola, Gbolahan, Morroni, Chelsea, Smeaton, Laura, Mmalane, Mompati, Makhema, Joseph, Shapiro, Roger L.

“…We investigated the impact of prolonged cotrimoxazole prophylaxis on growth in 2848 HIV-exposed uninfected children enrolled in the Mpepu study, a randomized,…”
Get full text

Safety and Efficacy of Starting Antiretroviral Therapy in the First Week of Life by Maswabi, Kenneth, Ajibola, Gbolahan, Bennett, Kara, Capparelli, Edmund V, Jean-Philippe, Patrick, Moyo, Sikhulile, Mohammed, Terence, Batlang, Oganne, Sakoi, Maureen, Lockman, Shahin, Makhema, Joseph, Lichterfeld, Mathias, Kuritzkes, Daniel R, Hughes, Michael D, Shapiro, Roger L

“…Abstract Background Early antiretroviral therapy (ART) is recommended for infants with human immunodeficiency virus (HIV) infection. However, few…”
Get full text

Caregivers of children with HIV in Botswana prefer monthly IV Broadly Neutralizing Antibodies (bNAbs) to daily oral ART by Sakoi-Mosetlhi, Maureen, Ajibola, Gbolahan, Haghighat, Roxanna, Batlang, Oganne, Maswabi, Kenneth, Pretorius-Holme, Molly, Powis, Kathleen M, Lockman, Shahin, Makhema, Joseph, Litcherfeld, Mathias, Kuritzkes, Daniel R, Shapiro, Roger

“…Monthly intravenous infusion of broadly neutralizing monoclonal antibodies may be an attractive alternative to daily oral antiretroviral treatment for children…”
Get full text

Are morbidity and mortality estimates from randomized controlled trials externally valid? A comparison of outcomes among infants enrolled into an RCT or a cohort study in Botswana by Thivalapill, Neil, Lockman, Shahin, Powis, Kathleen, Zash, Rebecca, Leidner, Jean, Ajibola, Gbolahan, Mmalane, Mompati, Makhema, Joseph, Shapiro, Roger L

“…Abstract Background The external validity of the randomized controlled trial (RCT) refers to the extent to which the results of the RCT apply to the relevant,…”
Get full text

Selection bias at the heterosexual HIV-1 transmission bottleneck by Carlson, Jonathan M., Schaefer, Malinda, Monaco, Daniela C., Batorsky, Rebecca, Claiborne, Daniel T., Prince, Jessica, Deymier, Martin J., Ende, Zachary S., Klatt, Nichole R., DeZiel, Charles E., Lin, Tien-Ho, Peng, Jian, Seese, Aaron M., Shapiro, Roger, Frater, John, Ndung'u, Thumbi, Tang, Jianming, Goepfert, Paul, Gilmour, Jill, Price, Matt A., Kilembe, William, Heckerman, David, Goulder, Philip J.R., Allen, Todd M., Allen, Susan, Hunter, Eric

“…HIV needs to be fit to transmit Although you might not think it, it's hard to catch HIV. Less than 1% of unprotected sexual exposures result in infection. What…”
Get full text

Protease Inhibitors and Adverse Birth Outcomes: Is Progesterone the Missing Piece to the Puzzle? by Powis, Kathleen M., Shapiro, Roger L.

Get full text

Viral Reservoir in Early-Treated Human Immunodeficiency Virus-Infected Children and Markers for Sustained Viral Suppression by Ajibola, Gbolahan, Garcia-Broncano, Pilar, Maswabi, Kenneth, Bennett, Kara, Hughes, Michael D, Moyo, Sikhulile, Mohammed, Terrence, Jean-Philippe, Patrick, Sakoi, Maureen, Batlang, Oganne, Lockman, Shahin, Makhema, Joseph, Kuritzkes, Daniel R, Lichterfeld, Mathias, Shapiro, Roger L

“…Abstract Background The impact of very early infant treatment on human immunodeficiency virus (HIV) reservoir, and markers for treatment success, require…”
Get full text

Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine by Lockman, Shahin, Shapiro, Roger L, Smeaton, Laura M, Wester, Carolyn, Thior, Ibou, Stevens, Lisa, Chand, Fatima, Makhema, Joseph, Moffat, Claire, Asmelash, Aida, Ndase, Patrick, Arimi, Peter, van Widenfelt, Erik, Mazhani, Loeto, Novitsky, Vladimir, Lagakos, Stephen, Essex, Max

“…This study analyzed the response to nevirapine-based antiretroviral treatment among 218 HIV-infected women in Botswana who had previously received either a…”
Get full text

Mortality among HIV-Exposed Infants: The First and Final Frontier by Shapiro, Roger L., Lockman, Shahin

Get full text