Search Results - "Shapiro, Martin A"

Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents by Tran, Tuan P., Ellsworth, Edmund L., Stier, Michael A., Domagala, John M., Hollis Showalter, H.D., Gracheck, Stephen J., Shapiro, Martin A., Joannides, Themis E., Singh, Rajeshwar

“…The synthesis and SAR of the 3-hydroxyquinazoline diones, a novel class of bacterial topoisomerase inhibitors, is reported. A series of…”
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Broad Spectrum Antimicrobial Biocides Target the FabI Component of Fatty Acid Synthesis by Heath, Richard J., Yu, Yuen-Tsu, Shapiro, Martin A., Olson, Eric, Rock, Charles O.

“…The broad spectrum antibacterial properties of 2-hydroxydiphenyl ethers have been appreciated for decades, and their use in consumer products is rapidly…”
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Structure−Activity Relationships of the Quinolone Antibacterials against Mycobacteria:  Effect of Structural Changes at N-1 and C-7 by Renau, Thomas E, Sanchez, Joseph P, Gage, Jeffrey W, Dever, Julie A, Shapiro, Martin A, Gracheck, Stephen J, Domagala, John M

“…The re-emergence of tuberculosis infections which are resistant to conventional drug therapy has demonstrated the need for alternative chemotherapy against…”
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3-Aminoquinazolinediones as a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-Type and Multidrug Resistant Organisms by Ellsworth, Edmund L, Tran, Tuan P, Hollis Showalter, H. D, Sanchez, Joseph P, Watson, Brian M, Stier, Michael A, Domagala, John M, Gracheck, Stephen J, Joannides, E. Themis, Shapiro, Martin A, Dunham, Steve A, Hanna, Debra L, Huband, Michael D, Gage, Jeffrey W, Bronstein, Joel C, Liu, Jia Yeu, Nguyen, Dai Q, Singh, Rajeshwar

“…The 3-aminoquinzolinediones represent a new series of antibacterial agents structurally related to the fluoroquinolones. They are inhibitors of bacterial…”
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The Synthesis, Structure-Activity, and Structure-Side Effect Relationships of a Series of 8-Alkoxy- and 5-Amino-8-alkoxyquinolone Antibacterial Agents by Sanchez, Joseph P, Gogliotti, Rocco D, Domagala, John M, Gracheck, Stephen J, Huband, Michael D, Sesnie, Josephine A, Cohen, Michael A, Shapiro, Martin A

“…A series of 1-cyclopropyl-6-fluoro-8-alkoxy (8-methyoxy and 8-ethoxy)-quionoline-3-carboxylic acids and…”
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Structure–activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors by Tran, Tuan P., Ellsworth, Edmund L., Sanchez, Joseph P., Watson, Brian M., Stier, Michael A., Showalter, H.D. Hollis, Domagala, John M., Shapiro, Martin A., Joannides, E. Themis, Gracheck, Stephen J., Nguyen, Dai Q., Bird, Paul, Yip, Judy, Sharadendu, Anurag, Ha, Chan, Ramezani, Saeed, Wu, Xiujuan, Singh, Rajeshwar

“…The syntheses and antibacterial SAR of the 3-aminoquinazolinediones are reported. A series of 3-aminoquinazolinediones was synthesized and evaluated for its…”
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Effect of Lipophilicity at N-1 on Activity of Fluoroquinolones against Mycobacteria by Renau, Thomas E, Sanchez, Joseph P, Shapiro, Martin A, Dever, Julie A, Gracheck, Stephen J, Domagala, John M

“…The dramatic increase in drug resistant Mycobacterium tuberculosis has caused a resurgence in research targeted toward these organisms. As part of a systematic…”
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Comparative therapeutic efficacy of clinafloxacin in a pneumococcal meningitis mouse model by Shapiro, Martin A., Donovan, Kurt D., Gage, Jeffrey W.

“…The therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, was compared with that of ciprofloxacin and ceftriaxone in a novel…”
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Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1-pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy by Domagala, John M, Hagen, Susan E, Joannides, Themis, Kiely, John S, Laborde, Edgardo, Schroeder, Mel C, Sesnie, Josephine A, Shapiro, Martin A, Suto, Mark J, Vanderroest, Steven

“…A series of stereochemically pure 7-[3-(1-aminoethyl)-1-pyrrolidinyl]-1, 4-dihydro-4-oxoquinoline and 1,8-naphthyridine-3-carboxylic acids, with varied…”
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Pharmacokinetics of Clinafloxacin Enantiomers in Humans by Humphrey, Gaye H., Shapiro, Martin A., Randinitis, Edward J., Guttendorf, Robert J., Brodfuehrer, Joanne I.

“…The pharmacokinetics of R‐clinafloxacin and S‐clinafloxacin enantiomers of the broad‐spectrum fluoroquinolone antibiotic, clinafloxacin, were characterized in…”
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Novel Nonpeptidic Inhibitors of Peptide Deformylase by Jayasekera, Maithri M.K., Kendall, Ann, Shammas, Ramy, Dermyer, Michael, Tomala, Matthew, Shapiro, Martin A., Holler, Tod P.

“…A novel series of nonpeptidic compounds structurally related to the known anticholesteremic thyropropic acid were found to inhibit Escherichia coli…”
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Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position by RENAU, T. E, GAGE, J. W, REYNOLDS, R. C, DEVER, J. A, ROLAND, G. E, JOANNIDES, E. T, SHAPIRO, M. A, SANCHEZ, J. P, GRACHECK, S. J, DOMAGALA, J. M, JACOBS, M. R

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Red and Blue Nation?: Consequences and Correction of America's Polarized Politics by Nivola, Pietro S, Brady, David W

“…America's polarized politics are largely disconnected from mainstream public preferences. This disconnect poses fundamental dangers for the representativeness…”
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Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model by SHAPIRO, M. A, SESNIE, J. C, DESATY, T. M, GRIFFIN, T. J, HEIFETZ, C. L

“…A deep-seated Pseudomonas aeruginosa mouse kidney abscess model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical…”
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Comparative therapeutic efficacy of clinafloxacin in leucopenic mice by SHAPIRO, M. A, DEVER, J. A, SESNIE, J. C, VANDERROEST, S. R

“…A cyclophosphamide-induced leucopenic mouse model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, with…”
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In vitro evaluation of cefdinir (FK482), a new oral cephalosporin with enhanced antistaphylococcal activity and beta-lactamase stability by Cohen, M A, Joannides, E T, Roland, G E, Meservey, M A, Huband, M D, Shapiro, M A, Sesnie, J C, Heifetz, C L

“…Cefdinir (FK482), a new oral cephalosporin with enhanced beta-lactamase stability, was tested by microbroth dilution against respiratory, urogenital, and skin…”
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A novel rapid throughput phototolerance screen in mice by Shapiro, Martin A., Sesnie, Josephine C., Joannides, E.Themis, Malta, Thomas E., Dever, Julie A., Heifetz, Carl L.

“…A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. It could prioritize or select…”
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Comparative in-vitro activity of enoxacin against penicillinase- and non-penicillinase-producing Neisseria gonorrhoeae by Shapiro, M A, Heifetz, C L, Sesnie, J C

“…The in-vitro antigonococcal activity of enoxacin was measured by a broth microdilution method. Comparisons were made with five clinically relevant marketed…”
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