Search Results - "Shapiro, Mariya B"

Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity by Shapiro, Mariya B., Cheever, Tracy, Malherbe, Delphine C., Pandey, Shilpi, Reed, Jason, Yang, Eun Sung, Wang, Keyun, Pegu, Amarendra, Chen, Xuejun, Siess, Don, Burke, David, Henderson, Heidi, Lewinsohn, Rebecca, Fischer, Miranda, Stanton, Jeffrey J., Axthelm, Michael K., Kahl, Christoph, Park, Byung, Lewis, Anne D., Sacha, Jonah B., Mascola, John R., Hessell, Ann J., Haigwood, Nancy L.

“…Vertical transmission accounts for most human immunodeficiency virus (HIV) infection in children, and treatments for newborns are needed to abrogate infection…”
Get full text

Advancing HIV Broadly Neutralizing Antibodies: From Discovery to the Clinic by Spencer, David A., Shapiro, Mariya B., Haigwood, Nancy L., Hessell, Ann J.

“…Despite substantial progress in confronting the global HIV-1 epidemic since its inception in the 1980s, better approaches for both treatment and prevention…”
Get full text

Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials by Balasubramanian, Preetha, Williams, Constance, Shapiro, Mariya B., Sinangil, Faruk, Higgins, Keith, Nádas, Arthur, Totrov, Maxim, Kong, Xiang-Peng, Fiore-Gartland, Andrew J., Haigwood, Nancy L., Zolla-Pazner, Susan, Hioe, Catarina E.

“…Immunization with HIV AIDSVAX gp120 vaccines in the phase III VAX003 and VAX004 trials did not confer protection. To understand the shortcomings in antibody…”
Get full text

Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates by Rosenberg, Yvonne J, Ordonez, Tracy, Khanwalkar, Urjeet S, Barnette, Philip, Pandey, Shilpi, Backes, Iara M, Otero, Claire E, Goldberg, Benjamin S, Crowley, Andrew R, Leib, David A, Shapiro, Mariya B, Jiang, Xiaoming, Urban, Lori A, Lees, Jonathan, Hessell, Ann J, Permar, Sallie, Haigwood, Nancy L, Ackerman, Margaret E

“…Transplacental transfer of maternal antibodies provides the fetus and newborn with passive protection against infectious diseases. While the role of the highly…”
Get full text

Hoxa9 and Flt3 signaling synergistically regulate an early checkpoint in lymphopoiesis by Gwin, Kimberly A, Shapiro, Mariya B, Dolence, Joseph J, Huang, Zhixin L, Medina, Kay L

“…Hoxa9 and Flt3 signaling are individually important for the generation of lymphoid lineage precursors from multipotent hematopoietic progenitors (MPP) in bone…”
Get full text

Differential requirement for Hoxa9 in the development and differentiation of B, NK, and DC-lineage cells from Flt3+ multipotential progenitors by Gwin, Kimberly, Dolence, Joseph J, Shapiro, Mariya B, Medina, Kay L

“…Hoxa9 is a homeodomain transcription factor important for the generation of Flt3+hiIL-7R- lymphoid biased-multipotential progenitors, Flt3+IL-7R+ common…”
Get full text

Reduced Cell-Associated DNA and Improved Viral Control in Macaques following Passive Transfer of a Single Anti-V2 Monoclonal Antibody and Repeated Simian/Human Immunodeficiency Virus Challenges by Hessell, Ann J, Shapiro, Mariya B, Powell, Rebecca, Malherbe, Delphine C, McBurney, Sean P, Pandey, Shilpi, Cheever, Tracy, Sutton, William F, Kahl, Christoph, Park, Byung, Zolla-Pazner, Susan, Haigwood, Nancy L

“…A high level of V1V2-specific IgG antibodies (Abs) in vaccinees' sera was the only independent variable that correlated with a reduced risk of human…”
Get full text

Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses by Hessell, Ann J., Powell, Rebecca, Jiang, Xunqing, Luo, Christina, Weiss, Svenja, Dussupt, Vincent, Itri, Vincenza, Fox, Alisa, Shapiro, Mariya B., Pandey, Shilpi, Cheever, Tracy, Fuller, Deborah H., Park, Byung, Krebs, Shelly J., Totrov, Maxim, Haigwood, Nancy L., Kong, Xiang-Peng, Zolla-Pazner, Susan

“…The V1V2 region of the HIV-1 envelope is the target of several broadly neutralizing antibodies (bNAbs). Antibodies to V1V2 elicited in the RV144 clinical trial…”
Get full text

Alpaca single B cell interrogation and heavy-chain-only antibody discovery on an optofluidic platform by Shapiro, Mariya B, Boucher, Jacqueline, Brousseau, Anna, Dehkharghani, Amin, Gabriel, Justin, Kamat, Vishal, Patil, Ketan, Gao, Feng, Walker, Jennifer, Kelly, Ryan, Souders, Colby A

“…Abstract In vivo VHH discovery approaches have been limited by the lack of methodologies for camelid B cell interrogation. Here, we report a novel application…”
Get full text

Immune perturbation following SHIV infection is greater in newborn macaques than in infants by Shapiro, Mariya B, Ordonez, Tracy, Pandey, Shilpi, Mahyari, Eisa, Onwuzu, Kosiso, Reed, Jason, Sidener, Heather, Smedley, Jeremy, Colgin, Lois M, Johnson, Amanda, Lewis, Anne D, Bimber, Benjamin, Sacha, Jonah B, Hessell, Ann J, Haigwood, Nancy L

“…Transmission of HIV-1 to newborns and infants remains high, with 130,000 new infections in 2022 in resource-limited settings. Half of HIV-infected newborns, if…”
Get full text

Flt3 signaling regulates the proliferation, survival, and maintenance of multipotent hematopoietic progenitors that generate B cell precursors by Dolence, Joseph J, Gwin, Kimberly A, Shapiro, Mariya B, Medina, Kay L

“…Flt3 signaling plays a crucial role in regulating the survival and differentiation of lymphoid progenitors into B cell precursors (BCPs) in bone marrow. To…”
Get full text

Changes at the 3'-untranslated region stabilize Rubisco activase transcript levels during heat stress in Arabidopsis by DeRidder, Benjamin P., Shybut, Mikel E., Dyle, Michael C., Kremling, Karl A. G., Shapiro, Mariya B.

“…Inhibition of photosynthesis by heat stress is accompanied by functional impairment of Rubisco's chápenme, activase (RCA), resulting in deactivation of…”
Get full text

Cell extrinsic alterations in splenic B cell maturation in Flt3‐ligand knockout mice by Dolence, Joseph J., Gwin, Kimberly A., Shapiro, Mariya B., Hsu, Fan‐Chi, Shapiro, Virginia S., Medina, Kay L.

“…B lymphopoiesis in bone marrow (BM) is critical for maintaining a diverse peripheral B cell pool to fight infection and establish lifelong immunity. The…”
Get full text