Search Results - "Shapiro, Irving M."

Role of cytokines in intervertebral disc degeneration: pain and disc content by Risbud, Makarand V., Shapiro, Irving M.

“…Key Points Intervertebral disc (IVD) degeneration is a common condition, affecting a large percentage of the adult population, with huge socio-economic costs…”
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Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice by Novais, Emanuel J., Tran, Victoria A., Johnston, Shira N., Darris, Kayla R., Roupas, Alex J., Sessions, Garrett A., Shapiro, Irving M., Diekman, Brian O., Risbud, Makarand V.

“…Intervertebral disc degeneration is highly prevalent within the elderly population and is a leading cause of chronic back pain and disability. Due to the link…”
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Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling by Choi, Hyowon, Merceron, Christophe, Mangiavini, Laura, Seifert, Erin L., Schipani, Ernestina, Shapiro, Irving M., Risbud, Makarand V.

“…Nucleus pulposus (NP) cells reside in the avascular and hypoxic microenvironment of intervertebral discs. Importantly, many activities related to survival and…”
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Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections by Gilbertie, Jessica M, Schnabel, Lauren V, Hickok, Noreen J, Jacob, Megan E, Conlon, Brian P, Shapiro, Irving M, Parvizi, Javad, Schaer, Thomas P

“…Bacterial invasion of synovial joints, as in infectious or septic arthritis, can be difficult to treat in both veterinary and human clinical practice…”
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Bicarbonate Recycling by HIF‐1–Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells by Silagi, Elizabeth S, Schoepflin, Zachary R, Seifert, Erin L, Merceron, Christophe, Schipani, Ernestina, Shapiro, Irving M, Risbud, Makarand V

“…ABSTRACT Intervertebral disc degeneration is a ubiquitous condition closely linked to chronic low‐back pain. The health of the avascular nucleus pulposus (NP)…”
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Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death by Silagi, Elizabeth S., Batista, Philip, Shapiro, Irving M., Risbud, Makarand V.

“…The integrity of the avascular nucleus pulposus (NP) phenotype plays a crucial role in the maintenance of intervertebral disc health. While advances have been…”
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Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus by Merceron, Christophe, Mangiavini, Laura, Robling, Alexander, Wilson, Tremika LeShan, Giaccia, Amato J, Shapiro, Irving M, Schipani, Ernestina, Risbud, Makarand V

“…The intervertebral disc (IVD) is one of the largest avascular organs in vertebrates. The nucleus pulposus (NP), a highly hydrated and proteoglycan-enriched…”
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COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells by Choi, Hyowon, Chaiyamongkol, Weera, Doolittle, Alexandra C., Johnson, Zariel I., Gogate, Shilpa S., Schoepflin, Zachary R., Shapiro, Irving M., Risbud, Makarand V.

“…The nucleus pulposus (NP) of intervertebral discs experiences dynamic changes in tissue osmolarity because of diurnal loading of the spine. TonEBP/NFAT5 is a…”
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The Proteasome Inhibitor Carfilzomib Suppresses Parathyroid Hormone-induced Osteoclastogenesis through a RANKL-mediated Signaling Pathway by Yang, Yanmei, Blair, Harry C., Shapiro, Irving M., Wang, Bin

“…Parathyroid hormone (PTH) induces osteoclast formation and activity by increasing the ratio of RANKL/OPG in osteoblasts. The proteasome inhibitor carfilzomib…”
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The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection by Antoci, Valentin, Adams, Christopher S, Parvizi, Javad, Davidson, Helen M, Composto, Russell J, Freeman, Theresa A, Wickstrom, Eric, Ducheyne, Paul, Jungkind, Donald, Shapiro, Irving M, Hickok, Noreen J

“…Abstract Peri-prosthetic infections are notoriously difficult to treat as the biomaterial implant is ideal for bacterial adhesion and biofilm formation,…”
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Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: Implications for cell-based transplantation therapy by RISBUD, Makarand V, ALBERT, Todd J, GUTTAPALLI, Asha, VRESILOVIC, Edward J, HILLIBRAND, Alan S, VACCARO, Alexander R, SHAPIRO, Irving M

“…Because mesenchymal stem cells can differentiate into chondrocyte-like cells, we ask the question, can mesenchymal stem cells commit to the nucleus pulposus…”
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Tetracycline tethered to titanium inhibits colonization by Gram-negative bacteria by Davidson, Helen, Poon, Martin, Saunders, Ray, Shapiro, Irving M., Hickok, Noreen J., Adams, Christopher S.

“…As peri-prosthetic infection is one of the most devastating complications associated with implant placement, we have reasoned that such infection can be…”
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Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression by Bohensky, Jolene, Leshinsky, Serge, Srinivas, Vickram, Shapiro, Irving M.

“…The goal of the study is to examine the relationship between the sensor molecules, Hypoxia Inducible Factor-1 (HIF-1), AMP activated Protein Kinase (AMPK) and…”
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Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus by Liu, Chao, Choi, Hyowon, Johnson, Zariel I., Tian, Jiwei, Shapiro, Irving M., Risbud, Makarand V.

“…Nucleus pulposus (NP) cells reside in a physiologically hyperosmotic environment within the intervertebral disc. TonEBP/NFAT5 is an osmo-sensitive…”
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GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc by Johnston, Shira N, Silagi, Elizabeth S, Madhu, Vedavathi, Nguyen, Duc H, Shapiro, Irving M, Risbud, Makarand V

“…Glycolysis is central to homeostasis of nucleus pulposus (NP) cells in the avascular intervertebral disc. Since the glucose transporter, GLUT1, is a highly…”
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Autophagy: a new phase in the maturation of growth plate chondrocytes is regulated by HIF, mTOR and AMP kinase by Srinivas, Vickram, Bohensky, Jolene, Shapiro, Irving M

“…The overall goal of the investigation was to examine autophagy in the growth plate and to ascertain how this process was regulated. Herein, we show that in the…”
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HIF‐1‐PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells by Fujita, Nobuyuki, Hirose, Yuichiro, Tran, Cassie M., Chiba, Kazuhiro, Miyamoto, Takeshi, Toyama, Yoshiaki, Shapiro, Irving M., Risbud, Makarand V.

“…ABSTRACT Intervertebral disc degeneration is the leading cause of chronic back pain. Recent studies show that raised level of SDC4, a cell‐surface heparan…”
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HIF-1 Regulation of Chondrocyte Apoptosis: Induction of the Autophagic Pathway by Bohensky, Jolene, Shapiro, Irving M., Leshinsky, Serge, Terkhorn, Shawn P., Adams, Christopher S., Srinivas, Vickram

“…The goal of our investigation was to explore the mechanism by which hypoxia regulates growth plate chondrocyte survival. At low O2 tension, chondrocytes were…”
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Autophagy in mineralizing tissues: Microenvironmental perspectives by Srinivas, Vickram, Bohensky, Jolene, Zahm, Adam M., Shapiro, Irving M.

“…Chondrocytes in the growth plate and articular cartilage and osteocytes subsumed in Haversian bone exist in environmental niches that are characterized by a…”
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Controlled release of vancomycin from thin sol-gel films on implant surfaces successfully controls osteomyelitis by Adams, Christopher S., Antoci Jr, Valentin, Harrison, Gerald, Patal, Payal, Freeman, Terry A., Shapiro, Irving M., Parvizi, Javad, Hickok, Noreen J., Radin, Shula, Ducheyne, Paul

“…Peri‐prosthetic infection remains a serious complication of joint replacement surgery. Herein, we demonstrate that a vancomycin‐containing sol‐gel film on Ti…”
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