Search Results - "Shapiro, DN"

Fusion of a Kinase Gene, ALK, to a Nucleolar Protein Gene, NPM, in Non-Hodgkin's Lymphoma by Morris, Stephan W., Kirstein, Mark N., Valentine, Marcus B., Dittmer, Kristopher G., Shapiro, David N., Saltman, David L., Look, A. Thomas

“…The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes. This rearrangement was…”
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A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1 by Jeon, I S, Davis, J N, Braun, B S, Sublett, J E, Roussel, M F, Denny, C T, Shapiro, D N

“…Most Ewing's sarcomas or related primitive neuroectodermal tumors have the (11;22)(q24;q12) or less frequently the (21;22)(q22;q12) translocation. These…”
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Pax3 Modulates Expression of the c-Met Receptor during Limb Muscle Development by Epstein, Jonathan A., Shapiro, David N., Cheng, Jane, Paula Y. P. Lam, Maas, Richard L.

“…Pax3 is a transcription factor whose expression has been used as a marker of myogenic precursor cells arising in the lateral somite destined to migrate to and…”
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Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes (∗) by Anderson, Dirk M., Kumaki, Satoru, Ahdieh, Minoo, Bertles, Jeanette, Tometsko, Mark, Loomis, Aaron, Giri, Judith, Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Valentine, Virginia, Shapiro, David N., Morris, Stephan W., Park, Linda S., Cosman, David

“…Interleukins-2 and −15 (IL-2 and IL-15) are cytokines with overlapping but distinct biological effects. Their receptors share two subunits (the IL-2Rβ and -γ…”
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Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma by Zhan, S, Shapiro, D N, Helman, L J

“…The insulin-like growth factor II (IGF2) gene is exclusively silent at the maternal allele in the mouse as well as in normal human tissues and is expressed at…”
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Biology and therapy of pediatric rhabdomyosarcoma by Pappo, A S, Shapiro, D N, Crist, W M, Maurer, H M

“…To review key developments in biology and therapy of rhabdomyosarcoma (RMS) since the early 1970s. The literature regarding biology, therapy, and late effects…”
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Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas by KHATIB, Z. A, MATSUSHIME, H, VALENTINE, M, SHAPIRO, D. N, SHERR, C. J, LOOK, A. T

“…The 34-kilodalton cyclin-dependent kinase, p34cdk4, is a major catalytic subunit of mammalian D-type cyclins, which act during the G1 phase of the cell cycle…”
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Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma by SHAPIRO, D. N, SUBLETT, J. E, BAITAO LI, DOWNING, J. R, NAEVE, C. W

“…Alveolar rhabdomyosarcoma, a malignant tumor of skeletal muscle, is characterized by a chromosomal translocation, t(2;13)(q35;q14). This translocation is…”
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Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma by Morris, S W, Kirstein, M N, Valentine, M B, Dittmer, K, Shapiro, D N, Look, A T, Saltman, D L

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Pax3 Inhibits Myogenic Differentiation of Cultured Myoblast Cells by Epstein, Jonathan A., Lam, Paula, Jepeal, Lisa, Maas, Richard L., Shapiro, David N.

“…Pax3 is an evolutionarily conserved transcription factor expressed in the lateral dermomyotome, a region that gives rise to limb muscle progenitors. Mutations…”
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Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization by REARDON, D. A, MICHALKIEWICZ, E, KUN, L. E, SHAPIRO, D. N, LOOK, A. T, BOYETT, J. M, SUBLETT, J. E, ENTREKIN, R. E, RAGSDALE, S. T, VALENTINE, M. B, BEHM, F. G, LI, H, HEIDEMAN, R. L

“…We analyzed 27 samples of primary medulloblastoma, using comparative genomic hybridization and a novel statistical approach to evaluate chromosomal regions for…”
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PAX3/Forkhead Homolog in Rhabdomyosarcoma Oncoprotein Activates Glucose Transporter 4 Gene Expression in Vivo and in Vitro by Armoni, Michal, Quon, Michael J., Maor, Gila, Avigad, Smadar, Shapiro, David N., Harel, Chava, Esposito, Diana, Goshen, Yaacov, Yaniv, Isaac, Karnieli, Eddy

“…Increased levels of glucose uptake and increased expression of the glucose transporter (GLUT) genes are characteristic features of tumors. In the…”
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Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma by Shapiro, D N, Jones, B G, Shapiro, L H, Dias, P, Houghton, P J

“…The expression of the insulin-like growth factors (IGFs) and their receptors has been linked to cellular proliferation and tumorigenicity in a number of model…”
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Loss of imprinting of IGF2 in Ewing's sarcoma by Zhan, S, Shapiro, D N, Helman, L J

“…Insulin-like Growth Factor 2 (IGF2) has recently been demonstrated to be maternally imprinted in both mice and humans. We previously reported loss of…”
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Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor by Dilling, M B, Dias, P, Shapiro, D N, Germain, G S, Johnson, R K, Houghton, P J

“…We show that cell lines derived from childhood alveolar rhabdomyosarcoma (RMS) are very sensitive to the growth-inhibitory effects of the immunosuppressive…”
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The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator by Sublett, J E, Jeon, I S, Shapiro, D N

“…Chimeric transcription factors, created by gene fusions as the result of chromosomal translocations, have been implicated in the pathogenesis of several…”
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Rhabdomyosarcoma. Biology and treatment by Pappo, A S, Shapiro, D N, Crist, W M

“…Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood. Recognition of specific genetic changes in the two most common subtypes of…”
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Homozygous deletion at chromosome 2q33 in human small-cell lung carcinoma identified by arbitrarily primed PCR genomic fingerprinting by Kohno, T, Morishita, K, Takano, H, Shapiro, D N, Yokota, J

“…We have searched for novel genetic alterations in human cancer cell lines by using the arbitrarily primed polymerase chain reaction (AP-PCR), which is a…”
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Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma by Shapiro, DN, Valentine, MB, Rowe, ST, Sinclair, AE, Sublett, JE, Roberts, WM, Look, AT

“…We assessed fluorescence in situ hybridization (FISH) as an alternative to Southern blot analysis for determination of N-myc gene amplification in…”
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Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction by Downing, JR, Head, DR, Parham, DM, Douglass, EC, Hulshof, MG, Link, MP, Motroni, TA, Grier, HE, Curcio-Brint, AM, Shapiro, DN

“…Ewing's sarcoma and the related primitive neuroectodermal tumor (PNET) share a unique and specific t(11;22)(q24;q12) chromosomal translocation. The breakpoints…”
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