Search Results - "Shapiro, D. N."

Biology and therapy of pediatric rhabdomyosarcoma by Pappo, A S, Shapiro, D N, Crist, W M, Maurer, H M

“…To review key developments in biology and therapy of rhabdomyosarcoma (RMS) since the early 1970s. The literature regarding biology, therapy, and late effects…”
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Factors associated with depression and anxiety in children with intellectual disabilities by Whitney, D. G., Shapiro, D. N., Peterson, M. D., Warschausky, S. A.

“…Background Individuals with intellectual disabilities (ID) are at increased risk for depression and anxiety disorders; however, there is a paucity of research…”
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Fusion of a Kinase Gene, ALK, to a Nucleolar Protein Gene, NPM, in Non-Hodgkin's Lymphoma by Morris, Stephan W., Kirstein, Mark N., Valentine, Marcus B., Dittmer, Kristopher G., Shapiro, David N., Saltman, David L., Look, A. Thomas

“…The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes. This rearrangement was…”
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Pax3 Modulates Expression of the c-Met Receptor during Limb Muscle Development by Epstein, Jonathan A., Shapiro, David N., Cheng, Jane, Paula Y. P. Lam, Maas, Richard L.

“…Pax3 is a transcription factor whose expression has been used as a marker of myogenic precursor cells arising in the lateral somite destined to migrate to and…”
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Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas by KHATIB, Z. A, MATSUSHIME, H, VALENTINE, M, SHAPIRO, D. N, SHERR, C. J, LOOK, A. T

“…The 34-kilodalton cyclin-dependent kinase, p34cdk4, is a major catalytic subunit of mammalian D-type cyclins, which act during the G1 phase of the cell cycle…”
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Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma by SHAPIRO, D. N, SUBLETT, J. E, BAITAO LI, DOWNING, J. R, NAEVE, C. W

“…Alveolar rhabdomyosarcoma, a malignant tumor of skeletal muscle, is characterized by a chromosomal translocation, t(2;13)(q35;q14). This translocation is…”
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Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma by Shapiro, DN, Valentine, MB, Rowe, ST, Sinclair, AE, Sublett, JE, Roberts, WM, Look, AT

“…We assessed fluorescence in situ hybridization (FISH) as an alternative to Southern blot analysis for determination of N-myc gene amplification in…”
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Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization by REARDON, D. A, MICHALKIEWICZ, E, KUN, L. E, SHAPIRO, D. N, LOOK, A. T, BOYETT, J. M, SUBLETT, J. E, ENTREKIN, R. E, RAGSDALE, S. T, VALENTINE, M. B, BEHM, F. G, LI, H, HEIDEMAN, R. L

“…We analyzed 27 samples of primary medulloblastoma, using comparative genomic hybridization and a novel statistical approach to evaluate chromosomal regions for…”
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Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma by Shapiro, D N, Jones, B G, Shapiro, L H, Dias, P, Houghton, P J

“…The expression of the insulin-like growth factors (IGFs) and their receptors has been linked to cellular proliferation and tumorigenicity in a number of model…”
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Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction by Downing, JR, Head, DR, Parham, DM, Douglass, EC, Hulshof, MG, Link, MP, Motroni, TA, Grier, HE, Curcio-Brint, AM, Shapiro, DN

“…Ewing's sarcoma and the related primitive neuroectodermal tumor (PNET) share a unique and specific t(11;22)(q24;q12) chromosomal translocation. The breakpoints…”
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Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma by Downing, JR, Khandekar, A, Shurtleff, SA, Head, DR, Parham, DM, Webber, BL, Pappo, AS, Hulshof, MG, Conn, WP, Shapiro, DN

“…Cytogenetic analysis has defined specific translocations associated with two of the most common small round cell tumors of childhood, t(11;22) in Ewing's…”
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Myogenic regulatory protein (MyoD1) expression in childhood solid tumors: diagnostic utility in rhabdomyosarcoma by Dias, P, Parham, DM, Shapiro, DN, Webber, BL, Houghton, PJ

“…Transcripts for the muscle regulatory gene MyoD1 are expressed during normal skeletal muscle myogenesis and in rhabdomyosarcomas but not in other tissues or in…”
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P-glycoprotein expression at diagnosis may not be a primary mechanism of therapeutic failure in childhood rhabdomyosarcoma by Kuttesch, J F, Parham, D M, Luo, X, Meyer, W H, Bowman, L, Shapiro, D N, Pappo, A S, Crist, W M, Beck, W T, Houghton, P J

“…To evaluate the prognostic significance of tumor cell P-glycoprotein (Pgp) expression at diagnosis in children with rhabdomyosarcoma. A panel of three anti-Pgp…”
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Rhabdomyosarcoma. Biology and treatment by Pappo, A S, Shapiro, D N, Crist, W M

“…Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood. Recognition of specific genetic changes in the two most common subtypes of…”
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Monoclonal antibodies to the myogenic regulatory protein MyoD1 : epitope mapping and diagnostic utility by DIAS, P, PARHAM, D. M, SHAPIRO, D. N, TAPSCOTT, S. J, HOUGHTON, P. J

“…Monoclonal antibodies (MoAbs) were developed against recombinant wild-type murine MyoD1 protein. Each of 4 MoAbs was immunologically reactive with recombinant…”
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Solid alveolar rhabdomyosarcomas with the t(2;13). Report of two cases with diagnostic implications by Parham, D M, Shapiro, D N, Downing, J R, Webber, B L, Douglass, E C

“…Two patients having rhabdomyosarcomas with the recently described "solid variant" pattern of alveolar rhabdomyosarcoma are reported. Both tumors had aggressive…”
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Chromosomal assignment and genomic structure of Il15 by Anderson, Dirk M., Johnson, Lisabeth, Glaccum, Moira B., Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Valentine, Virginia, Kirstein, Mark N., Shapiro, David N., Morris, Stephan W., Grabstein, Kenneth, Cosman, David

“…Interleukin-15 (IL-15) is a novel cytokine whose effects on T-cell activation and proliferation are similar to those of interleukin-2 (IL-2), presumably…”
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MyoD1 protein expression in alveolar soft part sarcoma as confirmatory evidence of its skeletal muscle nature by Rosai, J, Dias, P, Parham, D M, Shapiro, D N, Houghton, P

“…A typical case of alveolar soft part sarcoma was found to express in a strong and widespread fashion the marker MyoD1 protein. This nuclear phosphoprotein is…”
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Localization of the gene encoding human BiP/GRP78, the endoplasmic reticulum cognate of the HSP70 family, to chromosome 9q34 by Hendershot, L M, Valentine, V A, Lee, A S, Morris, S W, Shapiro, D N

“…BiP/GRP78 is a member of the HSP70 family involved in the folding and assembly of proteins in the endoplasmic reticulum. Using PCR amplification of DNA from…”
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Chromosomal localization of genes encoding CAN/Nup214-interacting proteins: Human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32 by FORNEROD, M, VAN BAAL, S, VALENTINE, V, SHAPIRO, D. N, GROSVELD, G

“…The CAN/Nup214 proto-oncogene, located on human chromosome 9q34, is involved in two different chromosomal rearrangements. Translocation (6; 9)(p23; q34)…”
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