Search Results - "Shapira, Sagi"

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells by Gupta, Piyush B., Fillmore, Christine M., Jiang, Guozhi, Shapira, Sagi D., Tao, Kai, Kuperwasser, Charlotte, Lander, Eric S.

“…Cancer cells within individual tumors often exist in distinct phenotypic states that differ in functional attributes. While cancer cell populations typically…”
Get full text

Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection by Ramlall, Vijendra, Thangaraj, Phyllis M., Meydan, Cem, Foox, Jonathan, Butler, Daniel, Kim, Jacob, May, Ben, De Freitas, Jessica K., Glicksberg, Benjamin S., Mason, Christopher E., Tatonetti, Nicholas P., Shapira, Sagi D.

“…Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and public health strategies. Viral–host interactions can guide discovery…”
Get full text

A Structure-Informed Atlas of Human-Virus Interactions by Lasso, Gorka, Mayer, Sandra V., Winkelmann, Evandro R., Chu, Tim, Elliot, Oliver, Patino-Galindo, Juan Angel, Park, Kernyu, Rabadan, Raul, Honig, Barry, Shapira, Sagi D.

“…While knowledge of protein-protein interactions (PPIs) is critical for understanding virus-host relationships, limitations on the scalability of…”
Get full text

Negative Regulation of Cytosolic Sensing of DNA by Abe, Takayuki, Shapira, Sagi D

“…In mammals, cytosolic detection of nucleic acids is critical in initiating innate antiviral responses against invading pathogens (like bacteria, viruses, fungi…”
Get full text

A Sweep of Earth's Virome Reveals Host-Guided Viral Protein Structural Mimicry and Points to Determinants of Human Disease by Lasso, Gorka, Honig, Barry, Shapira, Sagi D

“…Viruses deploy genetically encoded strategies to coopt host machinery and support viral replicative cycles. Here, we use protein structure similarity to scan…”
Get more information

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding by Tripathi, Shashank, Pohl, Marie O., Zhou, Yingyao, Rodriguez-Frandsen, Ariel, Wang, Guojun, Stein, David A., Moulton, Hong M., DeJesus, Paul, Che, Jianwei, Mulder, Lubbertus C.F., Yángüez, Emilio, Andenmatten, Dario, Pache, Lars, Manicassamy, Balaji, Albrecht, Randy A., Gonzalez, Maria G., Nguyen, Quy, Brass, Abraham, Elledge, Stephen, White, Michael, Shapira, Sagi, Hacohen, Nir, Karlas, Alexander, Meyer, Thomas F., Shales, Michael, Gatorano, Andre, Johnson, Jeffrey R., Jang, Gwen, Johnson, Tasha, Verschueren, Erik, Sanders, Doug, Krogan, Nevan, Shaw, Megan, König, Renate, Stertz, Silke, García-Sastre, Adolfo, Chanda, Sumit K.

“…Several systems-level datasets designed to dissect host-pathogen interactions during influenza A infection have been reported. However, apparent discordance…”
Get full text

A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection by Shapira, Sagi D., Gat-Viks, Irit, Shum, Bennett O.V., Dricot, Amelie, de Grace, Marciela M., Wu, Liguo, Gupta, Piyush B., Hao, Tong, Silver, Serena J., Root, David E., Hill, David E., Regev, Aviv, Hacohen, Nir

“…During the course of a viral infection, viral proteins interact with an array of host proteins and pathways. Here, we present a systematic strategy to…”
Get full text

Germ-Cell-Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization by Abe, Takayuki, Lee, Albert, Sitharam, Ramaswami, Kesner, Jordan, Rabadan, Raul, Shapira, Sagi D.

“…Cytosolic sensing of nucleic acids initiates tightly regulated programs to limit infection. Oocyte fertilization represents a scenario wherein inappropriate…”
Get full text

The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses by Goldstein, Tracey, Anthony, Simon J., Gbakima, Aiah, Bird, Brian H., Bangura, James, Tremeau-Bravard, Alexandre, Belaganahalli, Manjunatha N., Wells, Heather L., Dhanota, Jasjeet K., Liang, Eliza, Grodus, Michael, Jangra, Rohit K., DeJesus, Veronica A., Lasso, Gorka, Smith, Brett R., Jambai, Amara, Kamara, Brima O., Kamara, Sorie, Bangura, William, Monagin, Corina, Shapira, Sagi, Johnson, Christine K., Saylors, Karen, Rubin, Edward M., Chandran, Kartik, Lipkin, W. Ian, Mazet, Jonna A. K.

“…Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed ( Chaerephon…”
Get full text

A computational interactome and functional annotation for the human proteome by Garzón, José Ignacio, Deng, Lei, Murray, Diana, Shapira, Sagi, Petrey, Donald, Honig, Barry

“…We present a database, PrePPI (Predicting Protein-Protein Interactions), of more than 1.35 million predicted protein-protein interactions (PPIs). Of these at…”
Get full text

Systems biology approaches to dissect mammalian innate immunity by Shapira, Sagi D, Hacohen, Nir

“…Advances in experimental tools have allowed for the systematic identification of components and biological processes as well as quantification of their…”
Get full text

A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions by Stockman, Victoria B, Ghamsari, Lila, Lasso, Gorka, Honig, Barry, Shapira, Sagi D, Wang, Harris H

“…Comprehensive delineation of complex cellular networks requires high-throughput interrogation of genetic interactions. To address this challenge, we describe…”
Get full text

Transcriptional response modules characterize IL-1β and IL-6 activity in COVID-19 by Bell, Lucy C.K., Meydan, Cem, Kim, Jacob, Foox, Jonathan, Butler, Daniel, Mason, Christopher E., Shapira, Sagi D., Noursadeghi, Mahdad, Pollara, Gabriele

“…Dysregulated IL-1β and IL-6 responses have been implicated in the pathogenesis of severe Coronavirus Disease 2019 (COVID-19). Innovative approaches for…”
Get full text

Helminth Antigens Modulate TLR-Initiated Dendritic Cell Activation by Kane, Colleen M, Cervi, Laura, Sun, Jie, McKee, Amy S, Masek, Katherine S, Shapira, Sagi, Hunter, Christopher A, Pearce, Edward J

“…There is increasing awareness that helminth infections can ameliorate proinflammatory conditions. In part, this is due to their inherent ability to induce Th2…”
Get full text

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells by Gupta, Piyush B., Fillmore, Christine M., Jiang, Guozhi, Shapira, Sagi D., Tao, Kai, Kuperwasser, Charlotte, Lander, Eric S.

Get full text

Opposing roles of NF-κB family members in the regulation of NK cell proliferation and production of IFN-γ by Tato, Cristina M., Mason, Nicola, Artis, David, Shapira, Sagi, Caamano, Jorge C., Bream, Jay H., Liou, Hsiou-Chi, Hunter, Christopher A.

“…It is well established that the nuclear factor-κB (NF-κB) family of transcription factors participates in the regulation of many aspects of innate and adaptive…”
Get full text

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells by Gupta, Piyush B., Fillmore, Christine M., Jiang, Guozhi, Shapira, Sagi D., Tao, Kai, Kuperwasser, Charlotte, Lander, Eric S.

Get full text

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions by Butler, Daniel, Mozsary, Christopher, Meydan, Cem, Foox, Jonathan, Rosiene, Joel, Shaiber, Alon, Danko, David, Afshinnekoo, Ebrahim, MacKay, Matthew, Sedlazeck, Fritz J., Ivanov, Nikolay A., Sierra, Maria, Pohle, Diana, Zietz, Michael, Gisladottir, Undina, Ramlall, Vijendra, Sholle, Evan T., Schenck, Edward J., Westover, Craig D., Hassan, Ciaran, Ryon, Krista, Young, Benjamin, Bhattacharya, Chandrima, Ng, Dianna L., Granados, Andrea C., Santos, Yale A., Servellita, Venice, Federman, Scot, Ruggiero, Phyllis, Fungtammasan, Arkarachai, Chin, Chen-Shan, Pearson, Nathaniel M., Langhorst, Bradley W., Tanner, Nathan A., Kim, Youngmi, Reeves, Jason W., Hether, Tyler D., Warren, Sarah E., Bailey, Michael, Gawrys, Justyna, Meleshko, Dmitry, Xu, Dong, Couto-Rodriguez, Mara, Nagy-Szakal, Dorottya, Barrows, Joseph, Wells, Heather, O’Hara, Niamh B., Rosenfeld, Jeffrey A., Chen, Ying, Steel, Peter A. D., Shemesh, Amos J., Xiang, Jenny, Thierry-Mieg, Jean, Thierry-Mieg, Danielle, Iftner, Angelika, Bezdan, Daniela, Sanchez, Elizabeth, Campion, Thomas R., Sipley, John, Cong, Lin, Craney, Arryn, Velu, Priya, Melnick, Ari M., Shapira, Sagi, Hajirasouliha, Iman, Borczuk, Alain, Iftner, Thomas, Salvatore, Mirella, Loda, Massimo, Westblade, Lars F., Cushing, Melissa, Wu, Shixiu, Levy, Shawn, Chiu, Charles, Schwartz, Robert E., Tatonetti, Nicholas, Rennert, Hanna, Imielinski, Marcin, Mason, Christopher E.

“…In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) killed over a million people, including >25,000 in New York City…”
Get full text

System-wide transcriptome damage and tissue identity loss in COVID-19 patients by Park, Jiwoon, Foox, Jonathan, Hether, Tyler, Danko, David C., Warren, Sarah, Kim, Youngmi, Reeves, Jason, Butler, Daniel J., Mozsary, Christopher, Rosiene, Joel, Shaiber, Alon, Afshin, Evan E., MacKay, Matthew, Rendeiro, André F., Bram, Yaron, Chandar, Vasuretha, Geiger, Heather, Craney, Arryn, Velu, Priya, Melnick, Ari M., Hajirasouliha, Iman, Beheshti, Afshin, Taylor, Deanne, Saravia-Butler, Amanda, Singh, Urminder, Wurtele, Eve Syrkin, Schisler, Jonathan, Fennessey, Samantha, Corvelo, André, Zody, Michael C., Germer, Soren, Salvatore, Steven, Levy, Shawn, Wu, Shixiu, Tatonetti, Nicholas P., Shapira, Sagi, Salvatore, Mirella, Westblade, Lars F., Cushing, Melissa, Rennert, Hanna, Kriegel, Alison J., Elemento, Olivier, Imielinski, Marcin, Rice, Charles M., Borczuk, Alain C., Meydan, Cem, Schwartz, Robert E., Mason, Christopher E.

“…The molecular mechanisms underlying the clinical manifestations of coronavirus disease 2019 (COVID-19), and what distinguishes them from common seasonal…”
Get full text

NF-κB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS by Harris, Tajie H, Wilson, Emma H, Tait, Elia D, Buckley, Marie, Shapira, Sagi, Caamano, Jorge, Artis, David, Hunter, Christopher A

“…Abstract In this study, the role of NF-κB1 was examined during toxoplasmosis. While wildtype BALB/c mice generated protective responses, NF-κB1−/− mice…”
Get full text