Search Results - "Shao, Zhicheng"

Biocompatible Polymer-Grafted TiO2 Nanoparticle Sonosensitizers Prepared Using Phosphonic Acid-Functionalized RAFT Agent by Kitayama, Yukiya, Katayama, Aoi, Shao, Zhicheng, Harada, Atsushi

“…Sonodynamic therapy is widely used in clinical studies including cancer therapy. The development of sonosensitizers is important for enhancing the generation…”
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iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function by Ni, Peiyan, Noh, Haneul, Park, Gun-Hoo, Shao, Zhicheng, Guan, Youxin, Park, James M., Yu, Sophy, Park, Joy S., Coyle, Joseph T., Weinberger, Daniel R., Straub, Richard E., Cohen, Bruce M., McPhie, Donna L., Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi

“…Schizophrenia (SCZ) is a neurodevelopmental disorder. Thus, studying pathogenetic mechanisms underlying SCZ requires studying the development of brain cells…”
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Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia by Park, Gun-Hoo, Noh, Haneul, Shao, Zhicheng, Ni, Peiyan, Qin, Yiren, Liu, Dongxin, Beaudreault, Cameron P., Park, Joy S., Abani, Chiderah P., Park, James M., Le, Derek T., Gonzalez, Sasha Z., Guan, Youxin, Cohen, Bruce M., McPhie, Donna L., Coyle, Joseph T., Lanz, Thomas A., Xi, Hualin S., Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi

“…The mechanisms by which prenatal immune activation increase the risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical…”
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Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia by Shao, Zhicheng, Noh, Haneul, Bin Kim, Woong, Ni, Peiyan, Nguyen, Christine, Cote, Sarah E., Noyes, Elizabeth, Zhao, Joyce, Parsons, Teagan, Park, James M., Zheng, Kelvin, Park, Joshua J., Coyle, Joseph T., Weinberger, Daniel R., Straub, Richard E., Berman, Karen F., Apud, Jose, Ongur, Dost, Cohen, Bruce M., McPhie, Donna L., Rapoport, Judith L., Perlis, Roy H., Lanz, Thomas A., Xi, Hualin Simon, Yin, Changhong, Huang, Weihua, Hirayama, Teruyoshi, Fukuda, Emi, Yagi, Takeshi, Ghosh, Sulagna, Eggan, Kevin C., Kim, Hae-Young, Eisenberg, Leonard M., Moghadam, Alexander A., Stanton, Patric K., Cho, Jun-Hyeong, Chung, Sangmi

“…We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy…”
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Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing by Xue, Weiwei, Li, Bo, Liu, Huihui, Xiao, Yujie, Li, Bo, Ren, Lei, Li, Huijuan, Shao, Zhicheng

“…The spinal cord possesses highly complex, finely organized cytoarchitecture guided by two dorsoventral morphogenic organizing centers. Thus, generation of…”
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The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability by Zeng, Fanwei, Ma, Xuehai, Zhu, Lin, Xu, Qiang, Zeng, Yuzhe, Gao, Yue, Li, Guilin, Guo, Tiantian, Zhang, Haibin, Tang, Xiaoyan, Wang, Ziqiang, Ye, Zesen, Zheng, Liangkai, Zhang, Hongfeng, Zheng, Qiuyang, Li, Kunping, Lu, Jinfang, Qi, Xueting, Luo, Hong, Zhang, Xian, Wang, Zhanxiang, Zhou, Yulin, Yao, Yi, Ke, Rongqin, Zhou, Ying, Liu, Yan, Sun, Hao, Huang, Timothy, Shao, Zhicheng, Xu, Huaxi, Wang, Xin

“…Ubiquitin-specific protease (USP) 6 is a hominoid deubiquitinating enzyme previously implicated in intellectual disability and autism spectrum disorder…”
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The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis by Shao, Zhicheng, Zhang, Ruowen, Khodadadi-Jamayran, Alireza, Chen, Bo, Crowley, Michael R., Festok, Muhamad A., Crossman, David K., Townes, Tim M., Hu, Kejin

“…It is well known that both recipient cells and donor nuclei demonstrate a mitotic advantage as observed in the traditional reprogramming with somatic cell…”
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Modeling the precise interaction of glioblastoma with human brain region-specific organoids by Fan, Qi, Wang, Hanze, Gu, Tianyi, Liu, Huihui, Deng, Peng, Li, Bo, Yang, Hui, Mao, Ying, Shao, Zhicheng

“…Glioblastoma is a highly aggressive malignant tumor of the central nervous system, but the interaction between glioblastoma and different types of neurons…”
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Reprogramming by De-bookmarking the Somatic Transcriptional Program through Targeting of BET Bromodomains by Shao, Zhicheng, Yao, Chunping, Khodadadi-Jamayran, Alireza, Xu, Weihua, Townes, Tim M., Crowley, Michael R., Hu, Kejin

“…One critical event in reprogramming to pluripotency is erasure of the somatic transcriptional program of starting cells. Here, we present the proof of…”
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Long-working-distance high-collection-efficiency three-photon microscopy for in vivo long-term imaging of zebrafish and organoids by Deng, Peng, Liu, Shoupei, Zhao, Yaoguang, Zhang, Xinxin, Kong, Yufei, Liu, Linlin, Xiao, Yujie, Yang, Shasha, Hu, Jiahao, Su, Jixiong, Xuan, Ang, Xu, Jinhong, Li, Huijuan, Su, Xiaoman, Wu, Jingchuan, Jiang, Yuli, Mu, Yu, Shao, Zhicheng, Kong, Cihang, Li, Bo

“…Zebrafish and organoids, crucial for complex biological studies, necessitate an imaging system with deep tissue penetration, sample protection from…”
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Large-Scale Generation and Characterization of Homogeneous Populations of Migratory Cortical Interneurons from Human Pluripotent Stem Cells by Ni, Peiyan, Noh, Haneul, Shao, Zhicheng, Zhu, Qian, Guan, Youxin, Park, Joshua J., Arif, Fatima, Park, James M., Abani, Chiderah, Beaudreault, Cameron, Park, Joy S., Berry, Elizabeth, Moghadam, Alexander, Stanton, Patric, Hutchinson, John N., Andrews, Bill, Faux, Clare, Parnevelas, John, Eisenberg, Leonard M., Park, Kyungjoon, Bolshakov, Vadim Y., Chung, Sangmi

“…During development, cortical interneurons (cINs) are generated from the ventral telencephalon, robustly migrate to the dorsal telencephalon, make local…”
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Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation by Leng, Lige, Zhuang, Kai, Liu, Zeyue, Huang, Changquan, Gao, Yuehong, Chen, Guimiao, Lin, Hui, Hu, Yu, Wu, Di, Shi, Meng, Xie, Wenting, Sun, Hao, Shao, Zhicheng, Li, Huifang, Zhang, Kunkun, Mo, Wei, Huang, Timothy Y., Xue, Maoqiang, Yuan, Zengqiang, Zhang, Xia, Bu, Guojun, Xu, Huaxi, Xu, Qi, Zhang, Jie

“…Astrocyte dysfunction and inflammation are associated with the pathogenesis of major depressive disorder (MDD). However, the mechanisms underlying these…”
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Reprogramming Human Fibroblasts to Induced Pluripotent Stem Cells Using the GFP-Marked Lentiviral Vectors in the Chemically Defined Medium by Shao, Zhicheng, Cevallos, Ricardo Raúl, Hu, Kejin

“…Much investigation is needed to understand the underlying molecular mechanisms of iPSC reprogramming and to improve this technology. Lentivirus-mediated iPSC…”
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Biocompatible Polymer-Grafted TiO[sub.2] Nanoparticle Sonosensitizers Prepared Using Phosphonic Acid-Functionalized RAFT Agent by Kitayama, Yukiya, Katayama, Aoi, Shao, Zhicheng, Harada, Atsushi

“…Sonodynamic therapy is widely used in clinical studies including cancer therapy. The development of sonosensitizers is important for enhancing the generation…”
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Nanocage encapsulation improves antiepileptic efficiency of phenytoin by Zhao, Jie, Ye, Zesen, Yang, Jun, Zhang, Qiang, Shan, Wenjun, Wang, Xiumin, Wang, Zhanxiang, Ye, Shefang, Zhou, Xi, Shao, Zhicheng, Ren, Lei

“…More than 30% of patients with epilepsy progress to drug-resistant epilepsy, leading to a significant increase in morbidity and mortality of epilepsy. The…”
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Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes by Xu, Jinhong, Fang, Shi, Deng, Suixin, Li, Huijuan, Lin, Xiaoning, Huang, Yongheng, Chung, Sangmi, Shu, Yousheng, Shao, Zhicheng

“…Organoids with region-specific architecture could facilitate the repair of injuries of the central nervous system. Here we show that human astrocytes can be…”
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Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells (iPSCs) by Noh, Haneul, Shao, Zhicheng, Coyle, Joseph T., Chung, Sangmi

“…Schizophrenia is a chronic disabling mental disorder that affects about 1% population world-wide, for which there is a desperate need to develop more effective…”
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Biocompatible Polymer-Grafted TiO 2 Nanoparticle Sonosensitizers Prepared Using Phosphonic Acid-Functionalized RAFT Agent by Kitayama, Yukiya, Katayama, Aoi, Shao, Zhicheng, Harada, Atsushi

“…Sonodynamic therapy is widely used in clinical studies including cancer therapy. The development of sonosensitizers is important for enhancing the generation…”
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Effective cryopreservation of human brain tissue and neural organoids by Xue, Weiwei, Li, Huijuan, Xu, Jinhong, Yu, Xiao, Liu, Linlin, Liu, Huihui, Zhao, Rui, Shao, Zhicheng

“…Human brain tissue models and organoids are vital for studying and modeling human neurological disease. However, the high cost of long-term cultured organoids…”
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Activated microglia cause metabolic disruptions in developmental cortical interneuron that persist in schizophrenia-patient-derived interneurons by Park, Gun-Hoo, Noh, Haneul, Shao, Zhicheng, Ni, Peiyan, Qin, Yiren, Liu, Dongxin, Beaudreault, Cameron P., Park, Joy S., Abani, Chiderah P., Park, James M., Le, Derek T., Gonzalez, Sasha Z., Guan, Youxin, Cohen, Bruce M., McPhie, Donna L., Coyle, Joseph T., Lanz, Thomas A., Xi, Hualin S, Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi

“…The mechanisms by which prenatal immune activation increase risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical…”
Get full text