Search Results - "Shao, Yuefei"

Discovery of 2-aminoimidazopyridine adenosine A2A receptor antagonists by McGuinness, Brian F., Cole, Andrew G., Dong, Guizhen, Brescia, Marc-Raleigh, Shao, Yuefei, Henderson, Ian, Rokosz, Laura L., Stauffer, Tara M., Mannava, Neelima, Kimble, Earl F., Hicks, Catherine, White, Nicole, Wines, Pamela G., Quadros, Elizabeth

“…The synthesis and SAR of a novel series of A2A receptor antagonists are reported. A novel series of adenosine A2A receptor antagonists was identified by…”
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III. Identification of novel CXCR3 chemokine receptor antagonists with a pyrazinyl–piperazinyl–piperidine scaffold by Kim, Seong Heon, Anilkumar, Gopinadhan N., Zawacki, Lisa Guise, Zeng, Qingbei, Yang, De-Yi, Shao, Yuefei, Dong, Guizhen, Xu, Xiaolian, Yu, Wensheng, Jiang, Yueheng, Jenh, Chung-Her, Hall, James W., Carroll, Carolyn DiIanni, Hobbs, Doug W., Baldwin, John J., McGuinness, Brian F., Rosenblum, Stuart B., Kozlowski, Joseph A., Shankar, Bandarpalle B., Shih, Neng-Yang

“…The SAR of a novel pyrazinyl–piperazinyl–piperidine scaffold with CXCR3 receptor antagonist activity was explored. Optimization of the DMPK profile and…”
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II. SAR studies of pyridyl–piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists by Shao, Yuefei, Anilkumar, Gopinadhan N., Carroll, Carolyn DiIanni, Dong, Guizhen, Hall, James W., Hobbs, Doug W., Jiang, Yueheng, Jenh, Chung-Her, Kim, Seong Heon, Kozlowski, Joseph A., McGuinness, Brian F., Rosenblum, Stuart B., Schulman, Inna, Shih, Neng-Yang, Shu, Youheng, Wong, Michael K.C., Yu, Wensheng, Zawacki, Lisa Guise, Zeng, Qingbei

“…The structure–human CXCR3 binding affinity relationship of a series of pyridyl–piperazinyl-piperidine derivatives was explored. The structure–human CXCR3…”
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Sequence-Selective Peptide Detection by Small Synthetic Chemosensors Selected from an Encoded Combinatorial Chemosensor Library by Iorio, Edward James, Shao, Yuefei, Chen, Chao-Tsen, Wagner, Holger, Still, W.Clark

“…Synthetic chemosensors hold great potential in many diagnostic applications. In this study, we describe the design and preparation of the first encoded…”
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Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice by Lin, Tsung H., Hegen, Martin, Quadros, Elizabeth, Nickerson‐Nutter, Cheryl L., Appell, Kenneth C., Cole, Andrew G., Shao, Yuefei, Tam, Steve, Ohlmeyer, Michael, Wang, Bojing, Goodwin, Debra G., Kimble, Earl F., Quintero, Jorge, Gao, Min, Symanowicz, Peter, Wrocklage, Christopher, Lussier, Jennifer, Schelling, Scott H., Hewet, Amha G., Xuan, Dejun, Krykbaev, Rustem, Togias, Jenny, Xu, Xin, Harrison, Richard, Mansour, Tarek, Collins, Mary, Clark, James D., Webb, Maria L., Seidl, Katherine J.

“…Objective All γ‐chain cytokines signal through JAK‐3 and JAK‐1 acting in tandem. We undertook this study to determine whether the JAK‐3 selective inhibitor…”
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IV. Discovery of CXCR3 antagonists substituted with heterocycles as amide surrogates: improved PK, hERG and metabolic profiles by Nair, Anilkumar G, Wong, Michael K C, Shu, Youheng, Jiang, Yueheng, Jenh, Chung-Her, Kim, Seong Heon, Yang, De-Yi, Zeng, Qingbei, Shao, Yuefei, Zawacki, Lisa Guise, Duo, Jingqi, McGuinness, Brian F, Carroll, Carolyn Diianni, Hobbs, Doug W, Shih, Neng-Yang, Rosenblum, Stuart B, Kozlowski, Joseph A

“…The structure-human CXCR3 binding affinity relationship of a series of pyridyl/pyrazinyl-piperazinyl-piperidine derivatives were explored with a focus to…”
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Discovery of 2-aminoimidazopyridine adenosine A(2A) receptor antagonists by McGuinness, Brian F, Cole, Andrew G, Dong, Guizhen, Brescia, Marc-Raleigh, Shao, Yuefei, Henderson, Ian, Rokosz, Laura L, Stauffer, Tara M, Mannava, Neelima, Kimble, Earl F, Hicks, Catherine, White, Nicole, Wines, Pamela G, Quadros, Elizabeth

“…A novel series of adenosine A(2A) receptor antagonists was identified by high-throughput screening of an encoded combinatorial compound collection. The initial…”
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Synthesis and SAR studies of trisubstituted purinones as potent and selective adenosine A2A receptor antagonists by Shao, Yuefei, Cole, Andrew G, Brescia, Marc-Raleigh, Qin, Lan-Ying, Duo, Jingqi, Stauffer, Tara M, Rokosz, Laura L, McGuinness, Brian F, Henderson, Ian

“…A series of trisubstituted purinones was synthesized and evaluated as A(2A) receptor antagonists. The A(2A) structure-activity relationships at the three…”
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2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors by Cole, Andrew G., Bohnstedt, Adolph C., Paradkar, Vidyadhar, Kingsbury, Celia, Quintero, Jorge G., Park, Haengsoon, Lu, Yingchun, You, Ming, Neagu, Irina, Diller, David J., Letourneau, Jeffrey J., Shao, Yuefei, James, Ray A., Riviello, Christopher M., Ho, Koc-Kan, Lin, Tsung H., Wang, Bojing, Appell, Kenneth C., Sills, Matthew, Quadros, Elizabeth, Kimble, Earl F., Ohlmeyer, Michael H.J., Webb, Maria L.

“…A novel class of 2-benzimidazoylpurinone-based JAK3 inhibitors with excellent kinase activity is described. Compound 24 demonstrates good oral bioavailability…”
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Synthesis and SAR studies of trisubstituted purinones as potent and selective adenosine A 2A receptor antagonists by Shao, Yuefei, Cole, Andrew G., Brescia, Marc-Raleigh, Qin, Lan-Ying, Duo, Jingqi, Stauffer, Tara M., Rokosz, Laura L., McGuinness, Brian F., Henderson, Ian

“…A series of trisubstituted purinones was synthesized and evaluated as A 2A receptor antagonists. The A 2A structure–activity relationships at the three…”
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The novel and selective JAK3 inhibitor WYE-152038 is highly efficacious in a mouse model of rheumatoid arthritis by Seidl, Katherine J., Lin, Tsung H., Hegen, Martin, Quadros, Elizabeth, Nickerson-Nutter, Cheryl L., Appell, Kenneth C., Cole, Andrew G., Shao, Yuefei, Tam, Steve, Ohlmeyer, Michael, Wang, Bojing, Goodwin, Debra G., Kimble, Earl F., Quintero, Jorge, Gao, Min, Symanowicz, Peter, Wrocklage, Christopher, Lussier, Jennifer, Schelling, Scott H., Hewet, Amha G., Xuan, Dejun, Krykbaev, Rustem, Togias, Jennifer, Harrison, Richard, Xu, Xin, Collins, Mary, Clark, James D., Webb, Maria L.

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Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis by Guo, Tao, Shao, Yuefei, Qian, Gang, Rokosz, Laura L., Stauffer, Tara M., Hunter, Rachael C., Babu, Suresh D., Gu, Huizhong, Hobbs, Doug W.

“…[Display omitted] An encoded combinatorial library based on aryl and biaryl piperidine scaffolds was designed and synthesized. Screening of this library…”
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Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis: G-protein-coupled receptors in drug discovery by TAO GUO, YUEFEI SHAO, GANG QIAN, ROKOSZ, Laura L, STAUFFER, Tara M, HUNTER, Rachael C, BABU, Suresh D, HUIZHONG GU, HOBBS, Doug W

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Sequence-Selective Receptors of Peptides. A Simple Molecular Design for Construction of Large Combinatorial Libraries of Receptors by Shao, Yuefei, Still, W. Clark

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Synthetic receptors based on peptidosulfonamide peptidomimetics by Löwik, Dennis W.P.M., Mulders, Suzanne J.E., Cheng, Yuan, Shao, Yuefei, Liskamp, Rob M.J.

“…We have synthesized tweezer-like receptor molecules based on peptidosulfonamide peptidomimetics. These compounds were screened for binding against a ∼25,000…”
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Studies on synthetic receptors and receptor libraries by Shao, Yuefei

“…This thesis mainly involves studies of synthetic receptors for peptides via combinatorial chemistry approach, and development of new combinatorial…”
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