Search Results - "Shao, Wenlin"

Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure by Pagliarini, Raymond, Shao, Wenlin, Sellers, William R

“…A key goal of cancer therapeutics is to selectively target the genetic lesions that initiate and maintain cancer cell proliferation and survival. While most…”
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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling by Bauer, Andreas, Myer, Vic, Fawell, Stephen, Ghidelli, Sonja, Shi, Xiaoying, Rau, Christina, Schirle, Markus, Serluca, Fabrizio, Zhang, Yue, Bouwmeester, Tewis, Charlat, Olga, Mickanin, Craig, Curtis, Daniel, Stegmeier, Frank, Hild, Marc, Cong, Feng, Mishina, Yuji M, Wilson, Christopher J, Liu, Shanming, Wiessner, Stephanie, Tomlinson, Ronald, Fazal, Aleem, Shao, Wenlin, Shultz, Michael, Wiellette, Elizabeth, Michaud, Gregory A, Cheng, Hong, Schlegl, Judith, Finan, Peter M, Porter, Jeffery A, Lu, Chris, Cheung, Atwood, Lengauer, Christoph, Tallarico, John A, Kirschner, Marc W, Huang, Shih-Min A

“…The stability of the Wnt pathway transcription factor β-catenin is tightly regulated by the multi-subunit destruction complex. Deregulated Wnt pathway activity…”
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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF by Shao, Wenlin, Mishina, Yuji M, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G, Rivera, Stacy, Wang, Yingyun, Shen, Fang, Korn, Joshua M, Mathews Griner, Lesley A, Nishiguchi, Gisele, Rico, Alice, Tellew, John, Haling, Jacob R, Aversa, Robert, Polyakov, Valery, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P, Lees, Emma, Ramurthy, Savithri, Sellers, William R, Stuart, Darrin D

“…Resistance to the RAF inhibitor vemurafenib arises commonly in melanomas driven by the activated BRAF oncogene. Here, we report antitumor properties of RAF709,…”
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Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1 by Carroll, Jason S., Liu, X. Shirley, Brodsky, Alexander S., Li, Wei, Meyer, Clifford A., Szary, Anna J., Eeckhoute, Jerome, Shao, Wenlin, Hestermann, Eli V., Geistlinger, Timothy R., Fox, Edward A., Silver, Pamela A., Brown, Myles

“…Estrogen plays an essential physiologic role in reproduction and a pathologic one in breast cancer. The completion of the human genome has allowed the…”
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Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity by Borodovsky, Alexandra, Barbon, Christine M, Wang, Yanjun, Ye, Minwei, Prickett, Laura, Chandra, Dinesh, Shaw, Joseph, Deng, Nanhua, Sachsenmeier, Kris, Clarke, James D, Bolan Linghu, Brown, Giles A, Brown, James, Congreve, Miles, Cheng, Robert KY, Dore, Andrew S, Hurrell, Edward, Shao, Wenlin, Woessner, Richard, Reimer, Corinne, Drew, Lisa, Fawell, Stephen, Schuller, Alwin G, Mele, Deanna A

“…Accumulation of extracellular adenosine within the microenvironment is a strategy exploited by tumors to escape detection by the immune system. Adenosine…”
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Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor by Shultz, Michael D, Cheung, Atwood K, Kirby, Christina A, Firestone, Brant, Fan, Jianmei, Chen, Christine Hiu-Tung, Chen, Zhouliang, Chin, Donovan N, DiPietro, Lucian, Fazal, Aleem, Feng, Yun, Fortin, Pascal D, Gould, Ty, Lagu, Bharat, Lei, Huangshu, Lenoir, Francois, Majumdar, Dyuti, Ochala, Etienne, Palermo, M. G, Pham, Ly, Pu, Minying, Smith, Troy, Stams, Travis, Tomlinson, Ronald C, Touré, B. Barry, Visser, Michael, Wang, Run Ming, Waters, Nigel J, Shao, Wenlin

“…Tankyrase 1 and 2 have been shown to be redundant, druggable nodes in the Wnt pathway. As such, there has been intense interest in developing agents suitable…”
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Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model by Voronova, Veronika, Peskov, Kirill, Kosinsky, Yuri, Helmlinger, Gabriel, Chu, Lulu, Borodovsky, Alexandra, Woessner, Richard, Sachsenmeier, Kris, Shao, Wenlin, Kumar, Rakesh, Pouliot, Gayle, Merchant, Melinda, Kimko, Holly, Mugundu, Ganesh

“…Background Adenosine receptor type 2 (A 2A R) inhibitor, AZD4635, has been shown to reduce immunosuppressive adenosine effects within the tumor…”
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Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight by Touré, B. Barry, Giraldes, John, Smith, Troy, Sprague, Elizabeth R, Wang, Yaping, Mathieu, Simon, Chen, Zhuoliang, Mishina, Yuji, Feng, Yun, Yan-Neale, Yan, Shakya, Subarna, Chen, Dongshu, Meyer, Matthew, Puleo, David, Brazell, J. Tres, Straub, Christopher, Sage, David, Wright, Kirk, Yuan, Yanqiu, Chen, Xin, Duca, Jose, Kim, Sean, Tian, Li, Martin, Eric, Hurov, Kristen, Shao, Wenlin

“…MELK kinase has been implicated in playing an important role in tumorigenesis. Our previous studies suggested that MELK is involved in the regulation of cell…”
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Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling by SCHOUMACHER, Marie, HUROV, Kristen E, COOKE, Vesselina G, STEIGER, Janine, LEDELL, Jebediah, STUMP, Mark D, SELLERS, William R, DANIAL, Nika N, WENLIN SHAO, LEHAR, Joseph, YAN-NEALE, Yan, MISHINA, Yuji, SONKIN, Dmitriy, KORN, Joshua M, FLEMMING, Daisy, JONES, Michael D, ANTONAKOS, Brandon

“…Tankyrases (TNKS) play roles in Wnt signaling, telomere homeostasis, and mitosis, offering attractive targets for anticancer treatment. Using unbiased…”
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In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma by Ocio, Enrique M, Vilanova, David, Atadja, Peter, Maiso, Patricia, Crusoe, Edvan, Fernández-Lázaro, Diego, Garayoa, Mercedes, San-Segundo, Laura, Hernández-Iglesias, Teresa, de Alava, Enrique, Shao, Wenlin, Yao, Yung-Mae, Pandiella, Atanasio, San-Miguel, Jesús F

“…Combinations of drug treatments based on bortezomib or lenalidomide plus steroids have resulted in very high response rates in multiple myeloma. However, most…”
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Coactivator AIB1 Links Estrogen Receptor Transcriptional Activity and Stability by Shao, Wenlin, Keeton, Erika Krasnickas, McDonnell, Donald P., Brown, Myles, Eisenman, Robert N.

“…Agonist-mediated degradation of estrogen receptor α (ERα) has been associated with its transcriptional activity. However, the mechanism by which ERα is…”
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ERAP140, a Conserved Tissue-Specific Nuclear Receptor Coactivator by Shao, Wenlin, Halachmi, Shlomit, Brown, Myles

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells by Cidado, Justin, Boiko, Scott, Proia, Theresa, Ferguson, Douglas, Criscione, Steven W, San Martin, Maryann, Pop-Damkov, Petar, Su, Nancy, Roamio Franklin, Valar Nila, Sekhar Reddy Chilamakuri, Chandra, D'Santos, Clive S, Shao, Wenlin, Saeh, Jamal C, Koch, Raphael, Weinstock, David M, Zinda, Michael, Fawell, Stephen E, Drew, Lisa

“…Cyclin-dependent kinase 9 (CDK9) is a transcriptional regulator and potential therapeutic target for many cancers. Multiple nonselective CDK9 inhibitors have…”
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Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer by Arqués, Oriol, Chicote, Irene, Puig, Isabel, Tenbaum, Stephan P, Argilés, Guillem, Dienstmann, Rodrigo, Fernández, Natalia, Caratù, Ginevra, Matito, Judit, Silberschmidt, Daniel, Rodon, Jordi, Landolfi, Stefania, Prat, Aleix, Espín, Eloy, Charco, Ramón, Nuciforo, Paolo, Vivancos, Ana, Shao, Wenlin, Tabernero, Josep, Palmer, Héctor G

“…Oncogenic mutations in the KRAS/PI3K/AKT pathway are one of the most frequent alterations in cancer. Although PI3K or AKT inhibitors show promising results in…”
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Abstract 2500: Transient CDK9 inhibition with AZD4573 modulates Bfl-1 in preclinical lymphoma models by Boiko, Scott, Proia, Theresa, Martin, Maryann San, Drew, Lisa, Shao, Wenlin, Cidado, Justin

“…Abstract AZD4573 is a selective cyclin-dependent kinase 9 (CDK9) inhibitor under clinical development in patients with hematological malignancies. Transient…”
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Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies by Barlaam, Bernard, Casella, Robert, Cidado, Justin, Cook, Calum, De Savi, Chris, Dishington, Allan, Donald, Craig S, Drew, Lisa, Ferguson, Andrew D, Ferguson, Douglas, Glossop, Steve, Grebe, Tyler, Gu, Chungang, Hande, Sudhir, Hawkins, Janet, Hird, Alexander W, Holmes, Jane, Horstick, James, Jiang, Yun, Lamb, Michelle L, McGuire, Thomas M, Moore, Jane E, O’Connell, Nichole, Pike, Andy, Pike, Kurt G, Proia, Theresa, Roberts, Bryan, San Martin, Maryann, Sarkar, Ujjal, Shao, Wenlin, Stead, Darren, Sumner, Neil, Thakur, Kumar, Vasbinder, Melissa M, Varnes, Jeffrey G, Wang, Jianyan, Wang, Lei, Wu, Dedong, Wu, Liangwei, Yang, Bin, Yao, Tieguang

“…A CDK9 inhibitor having short target engagement would enable a reduction of Mcl-1 activity, resulting in apoptosis in cancer cells dependent on Mcl-1 for…”
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Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas by Boiko, Scott, Proia, Theresa, San Martin, Maryann, Gregory, Gareth P., Wu, Michelle Min, Aryal, Neeraj, Hattersley, Maureen, Shao, Wenlin, Saeh, Jamal C., Fawell, Stephen E., Johnstone, Ricky W., Drew, Lisa, Cidado, Justin

“…BH3 mimetics like venetoclax target prosurvival Bcl-2 family proteins and are important therapeutics in the treatment of hematological malignancies. We…”
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Abstract 1664: Inhibition of arginase in combination with radiation therapy shows increased immune-activation and anti-tumor activity in syngeneic tumor models by Schuller, Alwin, Doshi, Aatman, Cantin, Susan, Griffin, Matt, Martin, Maryann San, Proia, Theresa, Reimer, Corinne, Mlynarski, Scott, Finlay, Ray, Shao, Wenlin

“…Abstract The tumor microenvironment (TME) has multiple mechanisms of immune-suppression including recruitment of arginase (ARG) expressing myeloid cells. ARG…”
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The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins by Durand, Mathieu, Kolpak, Adrianne, Farrell, Timothy, Elliott, Nathan A, Shao, Wenlin, Brown, Myles, Volkert, Michael R

“…The NCOA7 gene product is an estrogen receptor associated protein that is highly similar to the human OXR1 gene product, which functions in oxidation…”
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Abstract 306: A mechanistic rationale for combining acalabrutinib with CDK9 inhibitor, AZD4573, in ABC-DLBCL by Boiko, Scott, Proia, Theresa, Martin, Maryann San, Cidado, Justin, Shao, Wenlin, Drew, Lisa

“…Abstract Cyclin-dependent kinase 9 (CDK9) regulates transcription elongation through phosphorylation of RNA polymerase II at serine 2 (pSer2-RNAPII), and its…”
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