Search Results - "Shao, Ruping"

Near-Infrared Light Triggers Release of Paclitaxel from Biodegradable Microspheres: Photothermal Effect and Enhanced Antitumor Activity by You, Jian, Shao, Ruping, Wei, Xin, Gupta, Sanjay, Li, Chun

“…Despite advances in controlled drug delivery, reliable methods for activatable, high‐resolution control of drug release are needed. The hypothesis that the…”
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Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells by Li, Hongyu, Hu, Jing, Wu, Shuhong, Wang, Li, Cao, Xiaobo, Zhang, Xiaoshan, Dai, Bingbing, Cao, Mengru, Shao, Ruping, Zhang, Ran, Majidi, Mourad, Ji, Lin, Heymach, John V, Wang, Michael, Pan, Shiyang, Minna, John, Mehran, Reza J, Swisher, Stephen G, Roth, Jack A, Fang, Bingliang

“…Auranofin, a gold complex that has been used to treat rheumatoid arthritis in clinics and has documented pharmacokinetic and safety profiles in humans, has…”
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Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells by Pataer, Apar, Ozpolat, Bulent, Shao, RuPing, Cashman, Neil R., Plotkin, Steven S., Samuel, Charles E., Lin, Steven H., Kabil, Nashwa N., Wang, Jing, Majidi, Mourad, Fang, Bingliang, Roth, Jack A., Vaporciyan, Ara A., Wistuba, Ignacio I., Hung, Mien-Chie, Swisher, Stephen G.

“…The role of RNA-dependent protein kinase R (PKR) and its association with misfolded protein expression in cancer cells are unclear. Herein we report that PKR…”
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TUSC2 immunogene enhances efficacy of chemo-immuno combination on KRAS/LKB1 mutant NSCLC in humanized mouse model by Meraz, Ismail M., Majidi, Mourad, Shao, RuPing, Meng, Feng, Ha, Min Jin, Shpall, Elizabeth, Roth, Jack A.

“…KRAS/LKB1 (STK11) NSCLC metastatic tumors are intrinsically resistant to anti-PD-1 or PD-L1 immunotherapy. In this study, we use a humanized mouse model to…”
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A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling by Lin, Jing, Zandi, Roza, Shao, Ruping, Gu, Jian, Ye, Yuanqin, Wang, Jing, Zhao, Yang, Pertsemlidis, Alexander, Wistuba, Ignacio I., Wu, Xifeng, Roth, Jack A., Ji, Lin

“…Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs713065) in the 3′UTR region of FZD4…”
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3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib by Meraz, Ismail M., Majidi, Mourad, Fang, Bingliang, Meng, Feng, Gao, Lihui, Shao, RuPing, Song, Renduo, Li, Feng, Lissanu, Yonathan, Chen, Huiqin, Ha, Min Jin, Wang, Qi, Wang, Jing, Shpall, Elizabeth, Jung, Sung Yun, Haderk, Franziska, Gui, Philippe, Riess, Jonathan Wesley, Olivas, Victor, Bivona, Trever G., Roth, Jack A.

“…Osimertinib sensitive and resistant NSCLC NCI-H1975 clones are used to model osimertinib acquired resistance in humanized and non-humanized mice and delineate…”
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Author Correction: 3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib by Meraz, Ismail M., Majidi, Mourad, Fang, Bingliang, Meng, Feng, Gao, Lihui, Shao, RuPing, Song, Renduo, Li, Feng, Lissanu, Yonathan, Chen, Huiqin, Ha, Min Jin, Wang, Qi, Wang, Jing, Shpall, Elizabeth, Jung, Sung Yun, Haderk, Franziska, Gui, Philippe, Riess, Jonathan Wesley, Olivas, Victor, Bivona, Trever G., Roth, Jack A.

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A novel method for imaging in vivo degradation of poly(L-glutamic acid), a biodegradable drug carrier by Melancon, Marites P, Wang, Wei, Wang, Yuetang, Shao, Ruping, Ji, Xiaojun, Gelovani, Juri G, Li, Chun

“…To develop an L-PG-based imaging probe suitable for assessing the degradation of L-PG in vivo. Conjugates of L-PG and a near-infrared fluorescence (NIRF) dye,…”
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Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer by YI DING, LI WANG, SU, Li-Kuo, FREY, Jennifer A, RUPING SHAO, HUNT, Kelly K, YAN, Duen-Hwa

“…We identified IFIX as a new member of the hematopoietic interferon (IFN)-inducible nuclear protein with the 200-amino-acid repeat (HIN-200) family. Six…”
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Targeting Phosphatidylserine on Apoptotic Cells with Phages and Peptides Selected from a Bacteriophage Display Library by Shao, Ruping, Xiong, Chiyi, Wen, Xiaoxia, Gelovani, Juri G., Li, Chun

“…Phosphatidylserine (PS) is a well-characterized biomarker for apoptosis. Ligands that bind to PS can be used for noninvasive imaging of therapy-induced cell…”
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E1A-mediated Paclitaxel Sensitization in HER-2/neu-overexpressing Ovarian Cancer SKOV3.ip1 through Apoptosis Involving the Caspase-3 Pathway by UENO, N. T, BARTHOLOMEUSZ, C, HUNG, M.-C, HERRMANN, J. L, ESTROV, Z, RUPING SHAO, ANDREEFF, M, PRICE, J, PAUL, R. W, ANKLESARIA, P, DIHUA YU

“…HER-2/ neu -overexpressing breast cancer cells are more resistant to the chemotherapeutic agent paclitaxel (Taxol) than low-HER-2/ neu -expressing breast…”
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p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis by Yang, H Y, Shao, R, Hung, M C, Lee, M H

“…HER2/neu, a receptor tyrosine kinase oncogene, promotes mitogenic growth and transformation of cancer cells. We previously identified that its oncogenic…”
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The tumor suppression activity of E1A in HER-2/neu-overexpressing breast cancer by JOE YUJIAO CHANG, XIA, W, SHAO, R, SORGI, F, HORTOBAGYI, G. N, HUANG, L, HUNG, M.-C

“…The HER-2/neu proto-oncogene is frequently amplified or overexpressed in human breast and ovarian cancers, and is significantly correlated with shorter…”
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E1A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis through Enhancement of Caspase Activation by Shao, Ruping, Lee, Dung-Fang, Wen, Yong, Ding, Yi, Xia, Weiya, Ping, Bo, Yagita, Hideo, Spohn, Bill, Hung, Mien-Chie

“…Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis of cancer cells. Sensitization of cancer cells to TRAIL,…”
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Inhibition of angiogenesis and induction of apoptosis are involved in E1A-mediated bystander effect and tumor suppression by RUPING SHAO, WEIYA XIA, HUNG, M.-C

“…Adenovirus type 5 E1A has been implicated in mediation of tumor suppression. Preclinical gene therapy studies have additionally shown that complete growth…”
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p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models by YONG WEN, YAN, Duen-Hwa, BAILIANG WANG, SPOHN, Bill, YI DING, RUPING SHAO, YIYU ZOU, KEPING XIE, HUNG, Mien-Chie

“…p202, an IFN-inducible protein, interacts with certain transcriptional activators leading to transcriptional repression. p202 expression has been associated…”
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Abstract 1105: Overcoming resistance to osimertinib by TUSC2 gene therapy in EGFR mutant NSCLC by Meraz, Ismail M., Majidi, Mourad, Shao, RuPing, Gao, Lihui, Feng, Meng, Chen, Huiqin, Ha, Min Jin, Roth, Jack A.

“…Abstract Osimertinib, the only third-generation EGFR-TKI approved for the treatment of T790M-mutant non-small cell lung cancer, shows robust clinical activity,…”
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Abstract 76: TUSC2 immunogene therapy enhances efficacy of chemo-immune combination therapy and induces robust antitumor immunity in KRAS-LKB1 mutant NSCLC in humanized mice by Meraz, Ismail M., Majidi, Mourad, Shao, RuPing, Meng, Feng, Ha, Min Jin, Shpall, Elizabeth, Roth, Jack A.

“…Abstract Oncogenic KRAS-LKB1 (KL)-mutant NSCLC lung cancers are resistant to immune checkpoint blockade (ICB) therapy due to impaired immunogenicity…”
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Proapoptotic and Antitumor Activities of Adenovirus-mediated p202 Gene Transfer by YI DING, YONG WEN, YAN, Duen-Hwa, SPOHN, Bill, LI WANG, WEIYA XIA, KA YIN KWONG, RUPING SHAO, ZHENG LI, HORTOBAGYI, Gabriel N, HUNG, Mien-Chie

“…Purpose and Experimental Design: p202, a mouse IFN-inducible protein, is a member of the 200-amino acid repeat family. Enforced p202 expression in stable…”
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Abstract 4454: TUSC2 immunogene therapy enhances efficacy of immunotherapy and targeted drugs in human non-small cell lung cancer (NSCLC) in humanized mouse models by Meraz, Ismail M., Majidi, Mourad, Feng, Meng, Shao, RuPing, Ha, Min Jin, Shpall, Elizabeth J., Roth, Jack A.

“…Abstract TUSC2 is a tumor suppressor gene, whose expression is reduced in almost all NSCLC. Systemic nanovesicle delivery of TUSC2 inhibits cancer cell growth…”
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