Search Results - "Shao, Daniel"

Isolation and retrieval of circulating tumor cells using centrifugal forces by Hou, Han Wei, Warkiani, Majid Ebrahimi, Khoo, Bee Luan, Li, Zi Rui, Soo, Ross A., Tan, Daniel Shao-Weng, Lim, Wan-Teck, Han, Jongyoon, Bhagat, Ali Asgar S., Lim, Chwee Teck

“…Presence and frequency of rare circulating tumor cells (CTCs) in bloodstreams of cancer patients are pivotal to early cancer detection and treatment…”
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Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells by Warkiani, Majid Ebrahimi, Guan, Guofeng, Luan, Khoo Bee, Lee, Wong Cheng, Bhagat, Ali Asgar S, Chaudhuri, Parthiv Kant, Tan, Daniel Shao-Weng, Lim, Wan Teck, Lee, Soo Chin, Chen, Peter C Y, Lim, Chwee Teck, Han, Jongyoon

“…The enumeration and characterization of circulating tumor cells (CTCs), found in the peripheral blood of cancer patients, provide a potentially accessible…”
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Methionine is a metabolic dependency of tumor-initiating cells by Wang, Zhenxun, Yip, Lian Yee, Lee, Jia Hui Jane, Wu, Zhengwei, Chew, Hui Yi, Chong, Pooi Kiat William, Teo, Chin Chye, Ang, Heather Yin-Kuan, Peh, Kai Lay Esther, Yuan, Ju, Ma, Siming, Choo, Li Shi Kimberly, Basri, Nurhidayah, Jiang, Xia, Yu, Qiang, Hillmer, Axel M., Lim, Wan Teck, Lim, Tony Kiat Hon, Takano, Angela, Tan, Eng Huat, Tan, Daniel Shao Weng, Ho, Ying Swan, Lim, Bing, Tam, Wai Leong

“…Understanding cellular metabolism holds immense potential for developing new classes of therapeutics that target metabolic pathways in cancer. Metabolic…”
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An ultra-high-throughput spiral microfluidic biochip for the enrichment of circulating tumor cells by Warkiani, Majid Ebrahimi, Khoo, Bee Luan, Tan, Daniel Shao-Weng, Bhagat, Ali Asgar S, Lim, Wan-Teck, Yap, Yoon Sim, Lee, Soo Chin, Soo, Ross A, Han, Jongyoon, Lim, Chwee Teck

“…The detection and characterization of rare circulating tumor cells (CTCs) from the blood of cancer patients can potentially provide critical insights into…”
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Genomic landscape of lung adenocarcinoma in East Asians by Chen, Jianbin, Yang, Hechuan, Teo, Audrey Su Min, Amer, Lidyana Bte, Sherbaf, Faranak Ghazi, Tan, Chu Quan, Alvarez, Jacob Josiah Santiago, Lu, Bingxin, Lim, Jia Qi, Takano, Angela, Nahar, Rahul, Lee, Yin Yeng, Phua, Cheryl Zi Jin, Chua, Khi Pin, Suteja, Lisda, Chen, Pauline Jieqi, Chang, Mei Mei, Koh, Tina Puay Theng, Ong, Boon-Hean, Anantham, Devanand, Hsu, Anne Ann Ling, Gogna, Apoorva, Too, Chow Wei, Aung, Zaw Win, Lee, Yi Fei, Wang, Lanying, Lim, Tony Kiat Hon, Wilm, Andreas, Choi, Poh Sum, Ng, Poh Yong, Toh, Chee Keong, Lim, Wan-Teck, Ma, Siming, Lim, Bing, Liu, Jin, Tam, Wai Leong, Skanderup, Anders Jacobsen, Yeong, Joe Poh Sheng, Tan, Eng-Huat, Creasy, Caretha L., Tan, Daniel Shao Weng, Hillmer, Axel M., Zhai, Weiwei

“…Lung cancer is the world’s leading cause of cancer death and shows strong ancestry disparities. By sequencing and assembling a large genomic and transcriptomic…”
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Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells by Khoo, Bee Luan, Warkiani, Majid Ebrahimi, Tan, Daniel Shao-Weng, Bhagat, Ali Asgar S, Irwin, Darryl, Lau, Dawn Pingxi, Lim, Alvin S T, Lim, Kiat Hon, Krisna, Sai Sakktee, Lim, Wan-Teck, Yap, Yoon Sim, Lee, Soo Chin, Soo, Ross A, Han, Jongyoon, Lim, Chwee Teck

“…Circulating tumor cells (CTCs) are cancer cells that can be isolated via liquid biopsy from blood and can be phenotypically and genetically characterized to…”
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Phase II study of nimotuzumab (TheraCim‐hR3) concurrent with cisplatin/radiotherapy in patients with locally advanced head and neck squamous cell carcinoma by Ang, Mei‐Kim, Montoya, Jose Enrique, Tharavichitkul, Ekkasit, Lim, Cindy, Tan, Terence, Wang, Lan Ying, Wee, Joseph, Soong, Yoke‐Lim, Fong, Kam‐Weng, Ng, Quan Sing, Tan, Daniel Shao‐Weng, Toh, Chee‐Keong, Tan, Eng‐Huat, Lim, Wan‐Teck

“…Background The efficacy of a combination of nimotuzumab, a humanized monoclonal antibody to the epidermal growth factor receptor, with chemoradiation in…”
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Addressing cellular heterogeneity in tumor and circulation for refined prognostication by Lim, Su Bin, Yeo, Trifanny, Di Lee, Wen, Bhagat, Ali Asgar S., Tan, Swee Jin, Tan, Daniel Shao Weng, Lim, Wan-Teck, Lim, Chwee Teck

“…Despite pronounced genomic and transcriptomic heterogeneity in non–small-cell lung cancer (NSCLC) not only between tumors, but also within a tumor, validation…”
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Safety, Tolerability, and Antitumor Activity of Zipalertinib Among Patients With Non-Small-Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Exon 20 Insertions by Piotrowska, Zofia, Tan, Daniel Shao-Weng, Smit, Egbert F, Spira, Alexander I, Soo, Ross A, Nguyen, Danny, Lee, Victor Ho-Fun, Yang, James Chih-Hsin, Velcheti, Vamsidhar, Wrangle, John M, Socinski, Mark A, Koczywas, Marianna, Janik, John E, Jones, Jeffrey, Yu, Helena Alexandra

“…Although several agents targeting epidermal growth factor receptor ( ) exon 20 insertions (ex20ins) have recently been approved by the US Food and Drug…”
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Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression by Zhang, Wen Cai, Chin, Tan Min, Yang, Henry, Nga, Min En, Lunny, Declan Patrick, Lim, Edwin Kok Hao, Sun, Li Li, Pang, Yin Huei, Leow, Yi Ning, Malusay, Shanneen Rossellini Y, Lim, Priscilla Xin Hui, Lee, Jeravan Zili, Tan, Benedict Jian Wei, Shyh-Chang, Ng, Lim, Elaine Hsuen, Lim, Wan Teck, Tan, Daniel Shao Weng, Tan, Eng Huat, Tai, Bee Choo, Soo, Ross Andrew, Tam, Wai Leong, Lim, Bing

“…The tumour-initiating cell (TIC) model accounts for phenotypic and functional heterogeneity among tumour cells. MicroRNAs (miRNAs) are regulatory molecules…”
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Effects of Single Nucleotide Polymorphisms on the Binding of Afatinib to EGFR: A Potential Patient Stratification Factor Revealed by Modeling Studies by Kannan, Srinivasaraghavan, Tan, Daniel Shao-Weng, Verma, Chandra Shekhar

“…The anticancer drug afatinib has been found to be more effective at inhibiting the oncogenic EGFR mutant exon 19 deletion (19del) over the oncogenic EGFR…”
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Ceritinib plus Nivolumab in Patients with Advanced ALK-Rearranged Non-Small Cell Lung Cancer: Results of an Open-Label, Multicenter, Phase 1B Study by Felip, Enriqueta, de Braud, Filippo G, Maur, Michela, Loong, Herbert H, Shaw, Alice Tsang, Vansteenkiste, Johan F, John, Thomas, Liu, Geoffrey, Lolkema, Martijn P, Selvaggi, Giovanni, Giannone, Vanessa, Cazorla, Pilar, Baum, Jason, Balbin, O Alejandro, Wang, Luojun Victor, Lau, Yvonne Y, Scott, Jeffrey W, Tan, Daniel Shao-Weng

“…Induction of programmed death ligand 1 (PD-L1) expression due to constitutive oncogenic signaling has been reported in NSCLC models harboring echinoderm…”
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Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma by Lim, Darren Wan-Teck, Kao, Hsiang-Fong, Suteja, Lisda, Li, Constance H., Quah, Hong Sheng, Tan, Daniel Shao-Weng, Tan, Sze-Huey, Tan, Eng-Huat, Tan, Wan-Ling, Lee, Justina Nadia, Wee, Felicia Yu-Ting, Jain, Amit, Goh, Boon-Cher, Chua, Melvin L. K., Liao, Bin-Chi, Ng, Quan Sing, Hong, Ruey-Long, Ang, Mei-Kim, Yeong, Joe Poh-Sheng, Iyer, N. Gopalakrishna

“…Single-agent checkpoint inhibitor (CPI) activity in Epstein-Barr Virus (EBV) related nasopharyngeal carcinoma (NPC) is limited. Dual CPI shows increased…”
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Real-world global data on targeting epidermal growth factor receptor mutations in stage III non-small-cell lung cancer: the results of the KINDLE study by Jazieh, Abdul Rahman, Onal, Huseyin Cem, Tan, Daniel Shao-Weng, Soo, Ross A., Prabhash, Kumar, Kumar, Amit, Huggenberger, Reto, Cho, Byoung Chul

“…Background: Tyrosine kinase inhibitors (TKIs) are the standard of care for resectable and metastatic non-small-cell lung cancer (NSCLC) harbouring epidermal…”
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Single‐cell profiling approaches to probing tumor heterogeneity by Khoo, Bee Luan, Chaudhuri, Parthiv Kant, Ramalingam, Naveen, Tan, Daniel Shao Weng, Lim, Chwee Teck, Warkiani, Majid Ebrahimi

“…Tumor heterogeneity is a major hindrance in cancer classification, diagnosis and treatment. Recent technological advances have begun to reveal the true extent…”
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Comparative Efficacy of Ceritinib and Crizotinib as Initial ALK-Targeted Therapies in Previously Treated Advanced NSCLC: An Adjusted Comparison with External Controls by Tan, Daniel Shao-Weng, Araújo, António, Zhang, Jie, Signorovitch, James, Zhou, Zheng-Yi, Cai, Xiaopeng, Liu, Geoffrey

“…Crizotinib and ceritinib have been developed to treat advanced or metastatic NSCLC by inhibiting anaplastic lymphoma receptor tyrosine kinase gene (ALK). No…”
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Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC) by Fong, Pei Yuan, Tan, Sze Huey, Lim, Darren Wan Teck, Tan, Eng Huat, Ng, Quan Sing, Sommat, Kiattisa, Tan, Daniel Shao Weng, Ang, Mei Kim

“…Treatment strategies in laryngeal squamous cell cancer (LSCC) straddle the need for long term survival and tumor control as well as preservation of laryngeal…”
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Concurrent Single-Cell RNA and Targeted DNA Sequencing on an Automated Platform for Comeasurement of Genomic and Transcriptomic Signatures by Kong, Say Li, Li, Huipeng, Tai, Joyce A, Courtois, Elise T, Poh, Huay Mei, Lau, Dawn Pingxi, Haw, Yu Xuan, Iyer, Narayanan Gopalakrishna, Tan, Daniel Shao Weng, Prabhakar, Shyam, Ruff, Dave, Hillmer, Axel M

“…The comeasurement of both genomic and transcriptomic signatures in single cells is of fundamental importance to accurately assess how the genetic information…”
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Phase I Study of Oral Vinorelbine in Combination with Erlotinib in Advanced Non-Small Cell Lung Cancer (NSCLC) Using Two Different Schedules by Sutiman, Natalia, Zhang, Zhenxian, Tan, Eng Huat, Ang, Mei Kim, Tan, Shao-Weng Daniel, Toh, Chee Keong, Ng, Quan Sing, Chowbay, Balram, Lim, Wan-Teck

“…This study aimed to evaluate the safety, tolerability and pharmacokinetics of the combination of oral vinorelbine with erlotinib using the conventional (CSV)…”
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Asian Thoracic Oncology Research Group (ATORG) Expert Consensus Statement on MET Alterations in NSCLC: Diagnostic and Therapeutic Considerations by Ahn, Myung-Ju, Mendoza, Marvin Jonne L., Pavlakis, Nick, Kato, Terufumi, Soo, Ross A., Kim, Dong-Wan, Liam, Chong Kin, Hsia, Te-Chun, Lee, Chee Khoon, Reungwetwattana, Thanyanan, Geater, Sarayut, Chan, Oscar Siu Hong, Prasongsook, Naiyarat, Solomon, Benjamin J., Nguyen, Thi Thai Hoa, Kozuki, Toshiyuki, Yang, James Chih-Hsin, Wu, Yi-Long, Mok, Tony Shu Kam, Tan, Daniel Shao-Weng, Yatabe, Yasushi

“…•MET alterations are associated with tumorigenesis and TKI resistance in patients with non-small cell lung cancer (NSCLC)•ATORG provides recommendations for…”
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