Search Results - "Shao, Cong"

The non-canonical NF-κB pathway in immunity and inflammation by Sun, Shao-Cong

“…Key Points NF-κB (nuclear factor-κB) activation is mediated by two main signalling pathways, the canonical and non-canonical pathways, which differ in both…”
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The noncanonical NF-κB pathway by Sun, Shao-Cong

“…The noncanonical nuclear factor‐κB (NF‐κB) signaling pathway mediates activation of the p52/RelB NF‐κB complex and, thereby, regulates specific immunological…”
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Non-canonical NF-κB signaling pathway by Sun, Shao-Cong

“…The non-canonical NF-κB pathway is an important arm of NF-κB signaling that predominantly targets activation of the p52/RelB NF-κB complex. This pathway…”
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Ubiquitin signaling in immune responses by Hu, Hongbo, Sun, Shao-Cong

“…Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in diverse biological pro- cesses, including different aspects of immune…”
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Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways by Shi, Jian-Hong, Sun, Shao-Cong

“…Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally related proteins that transduces signals from members of TNFR…”
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Deubiquitylation and regulation of the immune response by Sun, Shao-Cong

“…Key Points Ubiquitylation is a reversible process that is counter-regulated by ubiquitylating and enzymes deubiquitylating enzymes (DUBs). In addition to…”
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NF-κB signaling in inflammation by Liu, Ting, Zhang, Lingyun, Joo, Donghyun, Sun, Shao-Cong

“…The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses…”
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NF-κB in inflammation and renal diseases by Zhang, Haisong, Sun, Shao-Cong

“…Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in different aspects of immune responses. NF-κB is normally…”
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Targeting signaling factors for degradation, an emerging mechanism for TRAF functions by Yang, Xiao-Dong, Sun, Shao-Cong

“…Summary Tumor necrosis factor receptor (TNFR)‐associated factors (TRAFs) form a family of proteins that are best known as signaling adapters of TNFRs. However,…”
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A20 restricts inflammation via ubiquitin binding by Sun, Shao-Cong

“…The ubiquitin-editing enzyme A20 has a pivotal role in restricting autoimmune and inflammatory responses. New studies suggest that A20 prevents inflammatory…”
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Targeting ubiquitin signaling for cancer immunotherapy by Zhou, Xiaofei, Sun, Shao-Cong

“…Cancer immunotherapy has become an attractive approach of cancer treatment with tremendous success in treating various advanced malignancies. The development…”
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Regulation of nuclear factor-κB in autoimmunity by Sun, Shao-Cong, Chang, Jae-Hoon, Jin, Jin

“…Nuclear factor (NF)-κB transcription factors are pivotal regulators of innate and adaptive immune responses, and perturbations of NF-κB signaling contribute to…”
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Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation by Nakaya, Mako, Xiao, Yichuan, Zhou, Xiaofei, Chang, Jae-Hoon, Chang, Mikyoung, Cheng, Xuhong, Blonska, Marzenna, Lin, Xin, Sun, Shao-Cong

“…Glutamine has been implicated as an immunomodulatory nutrient, but how glutamine uptake is mediated during T cell activation is poorly understood. We have…”
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Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production by Jin, Wei, Sun, Shao-Cong, Chang, Mikyoung

“…The role of Pellino proteins in Toll-like receptor (TLR) signaling is not completely understood. Sun and colleagues now find that Pellino1 ubiquitinates the…”
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High-Performance Polyoxometalate-Based Cathode Materials for Rechargeable Lithium-Ion Batteries by Chen, Jia-Jia, Symes, Mark D., Fan, Shao-Cong, Zheng, Ming-Sen, Miras, Haralampos N., Dong, Quan-Feng, Cronin, Leroy

“…The polyoxovanadate cluster Li7[V15O36(CO3)] is shown to be an active cathode material in Li‐ion batteries, delivering a capacity of 250 mA h g−1 at 50 mA g−1…”
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The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming by Zhou, Xiaofei, Yu, Jiayi, Cheng, Xuhong, Zhao, Baoyu, Manyam, Ganiraju C., Zhang, Li, Schluns, Kimberly, Li, Pingwei, Wang, Jing, Sun, Shao-Cong

“…CD8 + T cells and natural killer (NK) cells are central cellular components of immune responses against pathogens and cancer, which rely on interleukin (IL)-15…”
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FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation by Yan, Jun, Zhao, Qingnan, Gabrusiewicz, Konrad, Kong, Ling-Yuan, Xia, Xueqing, Wang, Jian, Ott, Martina, Xu, Jingda, Davis, R. Eric, Huo, Longfei, Rao, Ganesh, Sun, Shao-Cong, Watowich, Stephanie S., Heimberger, Amy B., Li, Shulin

“…Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain tumor progression. Here we show that fibrinogen-like protein 2…”
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Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28 by Jiang, Yu, Liu, Ying, Lu, Huiping, Sun, Shao-Cong, Jin, Wei, Wang, Xiaohu, Dong, Chen

“…Epigenetic regulation is important for T-cell fate decision. Although STAT3 is known to initiate Th17 differentiation program, the downstream mechanism is…”
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NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity by Gu, Meidi, Zhou, Xiaofei, Sohn, Jee Hyung, Zhu, Lele, Jie, Zuliang, Yang, Jin-Young, Zheng, Xiaofeng, Xie, Xiaoping, Yang, Jie, Shi, Yaoyao, Brightbill, Hans D., Kim, Jae Bum, Wang, Jing, Cheng, Xuhong, Sun, Shao-Cong

“…Metabolic reprograming toward aerobic glycolysis is a pivotal mechanism shaping immune responses. Here we show that deficiency in NF-κB-inducing kinase (NIK)…”
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FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells by Meng, Xiangbo, Liu, Xiwei, Guo, Xingdong, Jiang, Shutan, Chen, Tingting, Hu, Zhiqiang, Liu, Haifeng, Bai, Yibing, Xue, Manman, Hu, Ronggui, Sun, Shao-cong, Liu, Xiaolong, Zhou, Penghui, Huang, Xiaowu, Wei, Lai, Yang, Wei, Xu, Chenqi

“…Dysfunctional T cells in the tumour microenvironment have abnormally high expression of PD-1 and antibody inhibitors against PD-1 or its ligand (PD-L1) have…”
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