Search Results - "Shanmukha Kumar, JV"

[18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates by Damuka, Naresh, Bashetti, Nagaraju, Mintz, Akiva, Bansode, Avinash H., Miller, Mack, Krizan, Ivan, Furdui, Cristina, Bhoopal, Bhuvanachandra, Gollapelli, Krishna Kumar, Shanmukha Kumar, JV, Deep, Gagan, Dugan, Greg, Cline, Mark, Solingapuram Sai, Kiran Kumar

“…Over production of reactive oxygen species (ROS) caused by altered redox regulation of signaling pathways is common in many types of cancers. While PET imaging…”
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Establishment of validated stability indicating purity method based on the stress degradation behavior of gonadotropin-releasing hormone antagonist (ganirelix) in an injectable formulation using HPLC and LC-MS-QTOF by Ummiti, Kumarswamy, Shanmukha Kumar, JV

“…Stress study of a drug substance or pharmaceutical drug product provides a vision into degradation pathways and degradation products of the active…”
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One-pot synthesis of novel tert-butyl-4-substituted phenyl-1H-1,2,3-triazolo piperazine/piperidine carboxylates, potential GPR119 agonists by Bashetti, Nagaraju, Shanmukha Kumar, J.V., Seelam, Naresh Varma, Prasanna, B., Mintz, Akiva, Damuka, Naresh, Devanathan, Sriram, Solingapuram Sai, Kiran Kumar

“…We have synthesized a new series of 1,2,3-triazolo piperazine and piperidine carboxylate derivatives using a simple and one-pot click chemistry with…”
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Synthesis and characterization of nanocomposite material based on graphene quantum dots and lanthanum doped zirconia nanoparticles: An electrochemical sensing application towards flutamide in urine samples by Trinadh, Thota, Khuntia, Harisankar, Anusha, Tummala, Bhavani, Kalli Sai, Kumar, J.V. Shanmukha, Brahman, Pradeep Kumar

“…Prostate cancer is one of the essential drivers of death around the globe. As a significant medication, flutamide has been utilized in the clinical treatment…”
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Fabrication of electrochemical immunosensor based on GCN-β-CD/Au nanocomposite for the monitoring of vitamin D deficiency by Anusha, Tummala, Bhavani, Kalli Sai, Shanmukha Kumar, J.V., Brahman, Pradeep Kumar, Hassan, Rabeay Y.A.

“…[Display omitted] •A label-free sensing probe is developed for 25(OH)D3 determination.•A low limit of detection, and a wide linear range were obtained.•The…”
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Designing and fabrication of electrochemical nanosensor employing fullerene-C60 and bimetallic nanoparticles composite film for the detection of vitamin D3 in blood samples by Anusha, Tummala, Bhavani, Kalli Sai, Kumar, J.V. Shanmukha, Brahman, Pradeep Kumar

“…Designing an accurate, selective and easy to operate the electrochemical analytical device for versatile applications is an important challenge for today and…”
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First GPR119 PET Imaging Ligand: Synthesis, Radiochemistry, and Preliminary Evaluations by Bansode, Avinash H., Damuka, Naresh, Bashetti, Nagaraju, Gollapelli, Krishna Kumar, Krizan, Ivan, Bhoopal, Bhuvanachandra, Miller, Mack, JV, Shanmukha Kumar, Whitlow, Christopher T., McClain, Donald, Ma, Tao, Jorgensen, Matthew J., Solingapuram Sai, Kiran Kumar

“…G-protein-coupled receptor 119 (GPR119) has emerged as a promising target for treating type 2 diabetes mellitus. Activating GPR119 improves glucose…”
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Evaluation of temperature, excipients impact on the primary structure of Ganirelix in an injectable formulation, and comparison with Orgalutran® using MALDI‐TOF/TOF‐MS by Ummiti, Kumarswamy, Kumar, J.V. Shanmukha

“…Ganirelix is a linear polypeptide consisting of covalently bonded 10 amino acid residues. The amino acid sequence in a peptide determines the properties of the…”
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Preliminary biological evaluations of first brain‐penetrant GPR119‐based radiotracer in rodents and non‐human primates by Bansode, Avinash, Damuka, Naresh, Krizan, Ivan, Miller, Mack, Bashetti, Nagaraju, Kumar, JV Shanmukha, Ma, Tao, Shively, Carol A., Lockhart, Samuel N., Whitlow, Christopher T., Craft, Suzanne, Jorgensen, Matthew J., Sai, Kiran K Solingapuram

“…Background G‐protein‐coupled receptors (GPCRs) plays a key role in regulating glucose metabolism. While GPR119 (an important GPCR) agonists have shown…”
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Preliminary biological evaluations of first brain‐penetrant GPR119‐based radiotracer in rodents and non‐human primates by Bansode, Avinash, Damuka, Naresh, Krizan, Ivan, Miller, Mack, Bashetti, Nagaraju, Kumar, JV Shanmukha, Ma, Tao, Shively, Carol A., Lockhart, Samuel N., Whitlow, Christopher T., Craft, Suzanne, Jorgensen, Matthew J., Sai, Kiran K Solingapuram

“…Background G‐protein‐coupled receptors (GPCRs) plays a key role in regulating glucose metabolism. While GPR119 (an important GPCR) agonists have shown…”
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