Search Results - "Shanmugham, Anitha"

Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-like Domain and Allosteric Regulation by GMP-Synthetase by Faesen, Alex C., Dirac, Annette M.G., Shanmugham, Anitha, Ovaa, Huib, Perrakis, Anastassis, Sixma, Titia K.

“…The ubiquitin-specific protease USP7/HAUSP regulates p53 and MDM2 levels, and cellular localization of FOXO4 and PTEN, and hence is critically important for…”
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The hydrophobic core of twin-arginine signal sequences orchestrates specific binding to Tat-pathway related chaperones by Shanmugham, Anitha, Bakayan, Adil, Völler, Petra, Grosveld, Joost, Lill, Holger, Bollen, Yves J M

“…Redox enzyme maturation proteins (REMPs) bind pre-proteins destined for translocation across the bacterial cytoplasmic membrane via the twin-arginine…”
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Catechol Pyrazolinones as Trypanocidals: Fragment-Based Design, Synthesis, and Pharmacological Evaluation of Nanomolar Inhibitors of Trypanosomal Phosphodiesterase B1 by Orrling, Kristina M, Jansen, Chimed, Vu, Xuan Lan, Balmer, Vreni, Bregy, Patrick, Shanmugham, Anitha, England, Paul, Bailey, David, Cos, Paul, Maes, Louis, Adams, Emily, van den Bogaart, Erika, Chatelain, Eric, Ioset, Jean-Robert, van de Stolpe, Andrea, Zorg, Stèphanie, Veerman, Johan, Seebeck, Thomas, Sterk, Geert Jan, de Esch, Iwan J. P, Leurs, Rob

“…Trypanosomal phosphodiesterases B1 and B2 (TbrPDEB1 and TbrPDEB2) play an important role in the life cycle of Trypanosoma brucei, the causative parasite of…”
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Surface plasmon resonance biosensor assay for the analysis of small-molecule inhibitor binding to human and parasitic phosphodiesterases by Siderius, Marco, Shanmugham, Anitha, England, Paul, van der Meer, Tiffany, Bebelman, Jan Paul, Blaazer, Antoni R., de Esch, Iwan J.P., Leurs, Rob

“…In the past decade, surface plasmon resonance (SPR) biosensor-based technology has been exploited more and more to characterize the interaction between drug…”
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Fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits by Blaazer, Antoni R, Orrling, Kristina M, Shanmugham, Anitha, Jansen, Chimed, Maes, Louis, Edink, Ewald, Sterk, Geert Jan, Siderius, Marco, England, Paul, Bailey, David, de Esch, Iwan J P, Leurs, Rob

“…Methods to discover biologically active small molecules include target-based and phenotypic screening approaches. One of the main difficulties in drug…”
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Membrane Binding of Twin Arginine Preproteins as an Early Step in Translocation by Shanmugham, Anitha, Wong Fong Sang, Harro W, Bollen, Yves J. M, Lill, Holger

“…The twin arginine transport (Tat) system translocates folded proteins across the bacterial inner membrane. Transport substrates are recognized by means of…”
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Nonhydrolyzable Ubiquitin−Isopeptide Isosteres as Deubiquitinating Enzyme Probes by Shanmugham, Anitha, Fish, Alexander, Luna-Vargas, Mark P. A, Faesen, Alex C, Oualid, Farid El, Sixma, Titia K, Ovaa, Huib

“…We demonstrate that oxime ligation is an efficient, straightforward, and generally applicable strategy for generating nonhydrolyzable ubiquitin (Ub)−isopeptide…”
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DUBs and disease: activity assays for inhibitor development by Shanmugham, Anitha, Ovaa, Huib

“…Deubiquitinating enzymes (DUBs) cleave ubiquitin from substrate proteins and so influence the biochemical properties of these proteins, such as their…”
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