Search Results - "Shanmugam, Renuka"

Keeping the eIF2 alpha kinase Gcn2 in check by Castilho, Beatriz A., Shanmugam, Renuka, Silva, Richard C., Ramesh, Rashmi, Himme, Benjamin M., Sattlegger, Evelyn

“…The protein kinase Gcn2 is present in virtually all eukaryotes and is of increasing interest due to its involvement in a large array of crucial biological…”
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Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2α phosphorylation by Shanmugam, Renuka, Anderson, Reuben, Schiemann, Anja H, Sattlegger, Evelyn

“…The protein kinase Gcn2 and its effector protein Gcn1 are part of the general amino acid control signalling (GAAC) pathway best known in yeast for its function…”
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Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2 by Cambiaghi, Tavane D., Pereira, Catia M., Shanmugam, Renuka, Bolech, Michael, Wek, Ronald C., Sattlegger, Evelyn, Castilho, Beatriz A.

“…•GCN1 is required for mammalian and yeast GCN2 function in a variety of conditions.•Mammalian IMPACT competes with GCN2 for GCN1 binding.•IMPACT and its yeast…”
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Fat feeding potentiates the diabetogenic effect of dexamethasone in Wistar rats by Sivabalan, Shanmugam, Renuka, Shanmugam, Menon, Venugopal P

“…The role of cortisol and its increased action/availability is implicated in the pathogenesis of insulin resistance associated with obesity and metabolic…”
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