Search Results - "Shanmugam, Muthu K"

Targeting autophagy using natural compounds for cancer prevention and therapy by Deng, Shuo, Shanmugam, Muthu K., Kumar, Alan Prem, Yap, Celestial T., Sethi, Gautam, Bishayee, Anupam

“…Autophagy, also known as macroautophagy, is a tightly regulated process involved in the stress responses, such as starvation. It is a vacuolar, lysosomal…”
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Analysis of the intricate relationship between chronic inflammation and cancer by Chai, Edna Zhi Pei, Siveen, Kodappully Sivaraman, Shanmugam, Muthu K, Arfuso, Frank, Sethi, Gautam

“…Deregulated inflammatory response plays a pivotal role in the initiation, development and progression of tumours. Potential molecular mechanism(s) that drive…”
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The Role of Resveratrol in Cancer Therapy by Ko, Jeong-Hyeon, Sethi, Gautam, Um, Jae-Young, Shanmugam, Muthu K, Arfuso, Frank, Kumar, Alan Prem, Bishayee, Anupam, Ahn, Kwang Seok

“…Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven…”
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Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer by Kannaiyan, Radhamani, Shanmugam, Muthu K, Sethi, Gautam

“…Abstract Identification of active constituents and their molecular targets from traditional medicine is an enormous opportunity for modern pharmacology…”
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The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy by Garg, Manoj, Shanmugam, Muthu K., Bhardwaj, Vipul, Goel, Akul, Gupta, Rajat, Sharma, Arundhiti, Baligar, Prakash, Kumar, Alan Prem, Goh, Boon Cher, Wang, Lingzhi, Sethi, Gautam

“…Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription factors, responsible for regulating cellular proliferation,…”
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Multifaceted link between cancer and inflammation by Sethi, Gautam, Shanmugam, Muthu K, Ramachandran, Lalitha, Kumar, Alan Prem, Tergaonkar, Vinay

“…Increasing evidence from epidemiological, preclinical and clinical studies suggests that dysregulated inflammatory response plays a pivotal role in a multitude…”
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Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer by Shanmugam, Muthu K, Warrier, Sudha, Kumar, Alan P, Sethi, Gautam, Arfuso, Frank

“…Neovascularization, also known as angiogenesis, is the process of capillary sprouting from pre-existing blood vessels. This physiological process is a hallmark…”
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Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence by Shanmugam, Muthu K, Dai, Xiaoyun, Kumar, Alan Prem, Tan, Benny K.H, Sethi, Gautam, Bishayee, Anupam

“…Abstract Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and…”
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Potential role of genipin in cancer therapy by Shanmugam, Muthu K., Shen, Hongyuan, Tang, Feng Ru, Arfuso, Frank, Rajesh, Mohanraj, Wang, Lingzhi, Kumar, Alan Prem, Bian, Jinsong, Goh, Boon Cher, Bishayee, Anupam, Sethi, Gautam

“…[Display omitted] Genipin, an aglycone derived from the iridoid glycoside, geniposide, is isolated and characterized from the extract of Gardenia jasminoides…”
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Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies by Shanmugam, Muthu K., Dai, Xiaoyun, Kumar, Alan Prem, Tan, Benny K.H., Sethi, Gautam, Bishayee, Anupam

“…Discovery of bioactive molecules and elucidation of their molecular mechanisms open up an enormous opportunity for the development of improved therapy for…”
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Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer by Shrimali, Deepti, Shanmugam, Muthu K, Kumar, Alan Prem, Zhang, Jingwen, Tan, Benny K.H, Ahn, Kwang Seok, Sethi, Gautam

“…Abstract Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural occurring anthraquinone derivative isolated from roots and barks of numerous plants,…”
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The multifaceted role of curcumin in cancer prevention and treatment by Shanmugam, Muthu K, Rane, Grishma, Kanchi, Madhu Mathi, Arfuso, Frank, Chinnathambi, Arunachalam, Zayed, M E, Alharbi, Sulaiman Ali, Tan, Benny K H, Kumar, Alan Prem, Sethi, Gautam

“…Despite significant advances in treatment modalities over the last decade, neither the incidence of the disease nor the mortality due to cancer has altered in…”
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Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds by Shanmugam, Muthu K, Lee, Jong Hyun, Chai, Edna Zhi Pei, Mathi, Kanchi Madhu, Kar, Shreya, Arfuso, Frank, Dharmarajan, Arunasalam, Kumar, Alan Prem, Samy, Ramar Perumal, Looi, Chung Yeng, Mustafa, Mohammad Rais, Tergaonkar, Vinay, Bishayee, Anupam, Ahn, Kwang Seok, Sethi, Gautam

“…Abstract The association between chronic inflammation and cancer development has been well documented. One of the major obstacles in cancer treatment is the…”
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Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression by Puar, Yu Rou, Shanmugam, Muthu K, Fan, Lu, Arfuso, Frank, Sethi, Gautam, Tergaonkar, Vinay

“…Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the regulation of a large number of genes that are involved in…”
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Role of Natural Products in Modulating Histone Deacetylases in Cancer by Merarchi, Myriam, Sethi, Gautam, Shanmugam, Muthu K, Fan, Lu, Arfuso, Frank, Ahn, Kwang Seok

“…Histone deacetylases (HDACs) are enzymes that can control transcription by modifying chromatin conformation, molecular interactions between the DNA and the…”
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Potential role of targeted therapies in the treatment of triple-negative breast cancer by Jia, Lee Yueh, Shanmugam, Muthu K, Sethi, Gautam, Bishayee, Anupam

“…Breast cancer is the most common cancer type that affects women and is the major cause of morbidity and mortality. Triple-negative breast cancer (TNBC) is an…”
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Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma by Subramaniam, Aruljothi, Shanmugam, Muthu K., Perumal, Ekambaram, Li, Feng, Nachiyappan, Alamelu, Dai, Xiaoyun, Swamy, Shivananju Nanjunda, Ahn, Kwang Seok, Kumar, Alan Prem, Tan, Benny K.H., Hui, Kam Man, Sethi, Gautam

“…Hepatocellular carcinoma (HCC) is one of the most lethal malignancies, and is also the fourth most common cancer worldwide with around 700,000 new cases each…”
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Role of RNF20 in cancer development and progression - a comprehensive review by Sethi, Gautam, Shanmugam, Muthu K, Arfuso, Frank, Kumar, Alan Prem

“…Evolving strategies to counter cancer initiation and progression rely on the identification of novel therapeutic targets that exploit the aberrant genetic…”
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Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer by Shanmugam, Muthu K, Nguyen, An H, Kumar, Alan P, Tan, Benny K.H, Sethi, Gautam

“…Abstract Over the last two decades, extensive research on plant-based medicinal compounds has revealed exciting and important pharmacological properties and…”
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Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis by Shanmugam, Muthu K, Ahn, Kwang Seok, Hsu, Annie, Woo, Chern Chiuh, Yuan, Yi, Tan, Kwong Huat Benny, Chinnathambi, Arunachalam, Alahmadi, Tahani Awad, Alharbi, Sulaiman Ali, Koh, Angele Pei Fern, Arfuso, Frank, Huang, Ruby Yun-Ju, Lim, Lina H K, Sethi, Gautam, Kumar, Alan Prem

“…Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated with increased cell proliferation, metastasis and also act as an indicator…”
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