Search Results - "Shanley, Mayra"

GMP-Compliant Universal Antigen Presenting Cells (uAPC) Promote the Metabolic Fitness and Antitumor Activity of Armored Cord Blood CAR-NK Cells by Liu, Enli, Ang, Sonny O T, Kerbauy, Lucila, Basar, Rafet, Kaur, Indreshpal, Kaplan, Mecit, Li, Li, Tong, Yijiu, Daher, May, Ensley, Emily L, Uprety, Nadima, Nunez Cortes, Ana Karen, Yang, Ryan Z, Li, Ye, Shaim, Hila, Reyes Silva, Francia, Lin, Paul, Mohanty, Vakul, Acharya, Sunil, Shanley, Mayra, Muniz-Feliciano, Luis, Banerjee, Pinaki P, Chen, Ken, Champlin, Richard E, Shpall, Elizabeth J, Rezvani, Katayoun

“…Natural killer (NK) cells are innate lymphocytes recognized for their important role against tumor cells. NK cells expressing chimeric antigen receptors (CARs)…”
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Metabolic Reprogramming of GMP Grade Cord Tissue Derived Mesenchymal Stem Cells Enhances Their Suppressive Potential in GVHD by Mendt, Mayela, Daher, May, Basar, Rafet, Shanley, Mayra, Kumar, Bijender, Wei Inng, Francesca Lim, Acharya, Sunil, Shaim, Hila, Fowlkes, Natalie, Tran, Jamie P, Gokdemir, Elif, Uprety, Nadima, Nunez-Cortes, Ana K, Ensley, Emily, Mai, Thao, Kerbauy, Lucila N, Melo-Garcia, Luciana, Lin, Paul, Shen, Yifei, Mohanty, Vakul, Lu, JunJun, Li, Sufang, Nandivada, Vandana, Wang, Jing, Banerjee, Pinaki, Reyes-Silva, Francia, Liu, Enli, Ang, Sonny, Gilbert, April, Li, Ye, Wan, Xinhai, Gu, Jun, Zhao, Ming, Baran, Natalia, Muniz-Feliciano, Luis, Wilson, Jeffrey, Kaur, Indreshpal, Gagea, Mihai, Konopleva, Marina, Marin, David, Tang, Guilin, Chen, Ken, Champlin, Richard, Rezvani, Katayoun, Shpall, Elizabeth J

“…Acute graft-vs.-host (GVHD) disease remains a common complication of allogeneic stem cell transplantation with very poor outcomes once the disease becomes…”
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Engineered cord blood megakaryocytes evade killing by allogeneic T-cells for refractory thrombocytopenia by Kumar, Bijender, Afshar-Kharghan, Vahid, Mendt, Mayela, Sackstein, Robert, Tanner, Mark R., Popat, Uday, Ramdial, Jeremy, Daher, May, Jimenez, Juan, Basar, Rafet, Melo Garcia, Luciana, Shanley, Mayra, Kaplan, Mecit, Wan, Xinhai, Nandivada, Vandana, Reyes Silva, Francia, Woods, Vernikka, Gilbert, April, Gonzalez-Delgado, Ricardo, Acharya, Sunil, Lin, Paul, Rafei, Hind, Banerjee, Pinaki Prosad, Shpall, Elizabeth J.

“…The current global platelet supply is often insufficient to meet all the transfusion needs of patients, in particular for those with alloimmune…”
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Activated B cells suppress T-cell function through metabolic competition by Imahashi, Nobuhiko, Basar, Rafet, Huang, Yuefan, Wang, Fang, Baran, Natalia, Banerjee, Pinaki Prosad, Lu, Junjun, Nunez Cortes, Ana Karen, Uprety, Nadima, Ensley, Emily, Muniz-Feliciano, Luis, Laskowski, Tamara J, Moyes, Judy S, Daher, May, Mendt, Mayela, Kerbauy, Lucila N, Shanley, Mayra, Li, Li, Lim, Francesca Lorraine Wei Inng, Shaim, Hila, Li, Ye, Konopleva, Marina, Green, Michael, Wargo, Jennifer, Shpall, Elizabeth J, Chen, Ken, Rezvani, Katayoun

“…B cells play a pivotal role in regulating the immune response. The induction of B cell-mediated immunosuppressive function requires B cell activating signals…”
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Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial by Marin, David, Li, Ye, Basar, Rafet, Rafei, Hind, Daher, May, Dou, Jinzhuang, Mohanty, Vakul, Dede, Merve, Nieto, Yago, Uprety, Nadima, Acharya, Sunil, Liu, Enli, Wilson, Jeffrey, Banerjee, Pinaki, Macapinlac, Homer A., Ganesh, Christina, Thall, Peter F., Bassett, Roland, Ammari, Mariam, Rao, Sheetal, Cao, Kai, Shanley, Mayra, Kaplan, Mecit, Hosing, Chitra, Kebriaei, Partow, Nastoupil, Loretta J., Flowers, Christopher R., Moseley, Sadie Mae, Lin, Paul, Ang, Sonny, Popat, Uday R., Qazilbash, Muzaffar H., Champlin, Richard E., Chen, Ken, Shpall, Elizabeth J., Rezvani, Katayoun

“…There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell therapies that are safe, effective and affordable. We conducted a phase 1/2…”
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KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape by Li, Ye, Basar, Rafet, Wang, Guohui, Liu, Enli, Moyes, Judy S., Li, Li, Kerbauy, Lucila N., Uprety, Nadima, Fathi, Mohsen, Rezvan, Ali, Banerjee, Pinaki P., Muniz-Feliciano, Luis, Laskowski, Tamara J., Ensley, Emily, Daher, May, Shanley, Mayra, Mendt, Mayela, Acharya, Sunil, Liu, Bin, Biederstädt, Alexander, Rafei, Hind, Guo, Xingliang, Melo Garcia, Luciana, Lin, Paul, Ang, Sonny, Marin, David, Chen, Ken, Bover, Laura, Champlin, Richard E., Varadarajan, Navin, Shpall, Elizabeth J., Rezvani, Katayoun

“…Trogocytosis is an active process that transfers surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical data, we…”
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Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma by Kirschenbaum, Daniel, Xie, Ken, Ingelfinger, Florian, Katzenelenbogen, Yonatan, Abadie, Kathleen, Look, Thomas, Sheban, Fadi, Phan, Truong San, Li, Baoguo, Zwicky, Pascale, Yofe, Ido, David, Eyal, Mazuz, Kfir, Hou, Jinchao, Chen, Yun, Shaim, Hila, Shanley, Mayra, Becker, Soeren, Qian, Jiawen, Colonna, Marco, Ginhoux, Florent, Rezvani, Katayoun, Theis, Fabian J, Yosef, Nir, Weiss, Tobias, Weiner, Assaf, Amit, Ido

“…Deciphering the cell-state transitions underlying immune adaptation across time is fundamental for advancing biology. Empirical in vivo genomic technologies…”
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Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood-Derived NK Cells Facilitates CAR-like Responses Against CD30 + Malignancies by Kerbauy, Lucila N, Marin, Nancy D, Kaplan, Mecit, Banerjee, Pinaki P, Berrien-Elliott, Melissa M, Becker-Hapak, Michelle, Basar, Rafet, Foster, Mark, Garcia Melo, Luciana, Neal, Carly C, McClain, Ethan, Daher, May, Nunez Cortes, Ana Karen, Desai, Sweta, Inng Lim, Francesca Wei, Mendt, Mayela Carolina, Schappe, Timothy, Li, Li, Shaim, Hila, Shanley, Mayra, Ensley, Emily L, Uprety, Nadima, Wong, Pamela, Liu, Enli, Ang, Sonny O, Cai, Rong, Nandivada, Vandana, Mohanty, Vakul, Miao, Qi, Shen, Yifei, Baran, Natalia, Fowlkes, Natalie W, Chen, Ken, Muniz-Feliciano, Luis, Champlin, Richard E, Nieto, Yago L, Koch, Joachim, Treder, Martin, Fischer, Wolfgang, Okamoto, Oswaldo Keith, Shpall, Elizabeth J, Fehniger, Todd A, Rezvani, Katayoun

“…Natural killer (NK)-cell recognition and function against NK-resistant cancers remain substantial barriers to the broad application of NK-cell immunotherapy…”
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Targeting the [alpha]v integrin/TGF-[beta] axis improves natural killer cell function against glioblastoma stem cells by Shaim, Hila, Shanley, Mayra, Basar, Rafet, Daher, May, Cumin, Joy, Zamler, Daniel B, Uprety, Nadima, Wang, Fang, Huang, Yuefan, Gabrusiewicz, Konrad, Miao, Qi, Dou, Jinzhuang

“…Glioblastoma multiforme (GBM), the most aggressive brain cancer, recurs because glioblastoma stem cells (GSCs) are resistant to all standard therapies. We…”
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NK Cell Dysfunction in CLL Is Mediated through SHP-1 Signaling and Is Associated with Poor Prognosis by Shaim, Hila, Rafei, Hind, Kaplan, Mecit, Basar, Rafet, Daher, MD, May, Shanley, Mayra, Banerjee, Pinaki, Kumar, Bijender, Nunez Cortes, Ana K., Islam, Sanjida, Jiang, Xin Ru, Kerbauy, Lucila Nassif, Lin, Paul, Gokdemir, Elif, Uprety, Nadima, Acharya, Sunil, Mendt, Mayela Carolina, Melo Garcia, Luciana, Biederstädt, Alexander, Liu, Bin, Liu, Enli, Ang, Sonny, Burger, Jan A., Wierda, William G., Ferrajoli, Alessandra, Shpall, Elizabeth J., Rezvani, Katayoun

“…Chronic lymphocytic leukemia (CLL) is a heterogeneous disease, presenting with a highly variable clinical course, outcome and response to therapy. This…”
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Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial by Weathers, Shiao-Pei, Penas-Prado, Marta, Pei, Be-Lian, Ling, Xiaoyang, Kassab, Cynthia, Banerjee, Pinaki, Bdiwi, Mustafa, Shaim, Hila, Alsuliman, Abdullah, Shanley, Mayra, de Groot, John F, O'Brien, Barbara J, Harrison, Rebecca, Majd, Nazanin, Kamiya-Matsuoka, Carlos, Fuller, Gregory N, Huse, Jason T, Chi, Linda, Rao, Ganesh, Weinberg, Jeffrey S, Lang, Frederick F, Sawaya, Raymond, Shpall, Elizabeth J, Rezvani, Katayoun, Heimberger, Amy B

“…Cytomegalovirus (CMV) antigens occur in glioblastoma but not in normal brains, making them desirable immunologic targets. Highly functional autologous…”
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Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD by Shanley, Mayra, Daher, May, Dou, Jinzhuang, Li, Sufang, Basar, Rafet, Rafei, Hind, Dede, Merve, Gumin, Joy, Pantaleόn Garcίa, Jezreel, Nunez Cortes, Ana Karen, He, Shan, Jones, Corry M, Acharya, Sunil, Fowlkes, Natalie W, Xiong, Donghai, Singh, Sanjay, Shaim, Hila, Hicks, Samantha Claire, Liu, Bin, Jain, Abhinav, Zaman, Mohammad Fayyad, Miao, Qi, Li, Ye, Uprety, Nadima, Liu, Enli, Muniz-Feliciano, Luis, Deyter, Gary M, Mohanty, Vakul, Zhang, Patrick, Evans, Scott E, Shpall, Elizabeth J, Lang, Frederick F, Chen, Ken, Rezvani, Katayoun

“…Glioblastoma (GBM) is an aggressive brain cancer with limited therapeutic options. Natural killer (NK) cells are innate immune cells with strong anti-tumor…”
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Generation and Screening of Various CD70 CAR NK Cells Identify the Most Effective Construct Against Hematologic Malignancies by Acharya, Sunil, Basar, Rafet, Daher, MD, May, Li, Ping, Rafei, Hind, Uprety, Nadima, Ensley, Emily, Shanley, Mayra, Kumar, Bijender, Banerjee, Pinaki, Melo Garcia, Luciana, Lin, Paul, Mohanty, Vakul, Pan, Yuchen, Miao, Qi, Kim, Kun Hee, Jiang, Xianli, Li, Ye, Liu, Bin, Nunez Cortes, Ana K., Zhang, Patrick, Fathi, Mohsen, Rezvan, Ali, Montalvo, Melisa J, Liu, Enli, Varadarajan, Navin, Chen, Ken, Marin, David, Champlin, Richard E., Shpall, Elizabeth J., Rezvani, Katayoun

“…The ability to re-direct the intrinsic power of the immune system against cancer has resulted in unprecedented outcomes in certain patients with otherwise…”
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Targeting T-Cell Lymphoma Using CD70-Directed Cord Blood-Derived CAR-NK Cells by Rafei, Hind, Basar, Rafet, Acharya, Sunil, Zhang, Patrick, Liu, Pinghua, Moseley, Sadie Mae, Li, Ping, Daher, MD, May, Agarwal, Nitin, Marques-Piubelli, Mario L., Uprety, Nadima, Melo Garcia, Luciana, Shanley, Mayra, Banerjee, Pinaki, Li, Ye, Rosemore, Samuel Levi, Kumar, Bijender, Nunez Cortes, Ana K., Biederstädt, Alexander, Islam, Sanjida, Kaplan, Mecit, Hu, Bingqian, Manzar, Gohar, Lin, Paul, Marin, David, Champlin, Richard E., Vega, Francisco, Shpall, Elizabeth J., Rezvani, Katayoun

“…T-cell lymphomas (TCL) are a heterogenous group of non-Hodgkin lymphoma characterized by resistance to conventional therapies posing an urgent need for safe…”
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DAP10 Co-Stimulation Imparts Memory-like Features to CD5 Targeting Cord Blood Derived CAR-NK Cells by Basar, Rafet, Daher, MD, May, Uprety, Nadima, Ensley, Emily, Nunez Cortes, Ana K., Acharya, Sunil, Shrestha, Rejeena, Liu, Bin, Shanley, Mayra, Li, Ye, Silva Reyes, Francia, Dede, Merve, Rafei, Hind, Shaim, Hila, Kaplan, Mecit, Lin, Paul, Banerjee, Pinaki, Mohanty, Vakul, Dou, Jinhuang, Mendt, Mayela Carolina, Miao, Qi, Ammari, Mariam, Liu, Enli, Guo, Xingliang, Kumar, Bijender, Biederstädt, Alexander, Jiang, Xin Ru, Ang, Sonny, Varadarajan, Navin, Champlin, Richard E., Chen, Ken, Marin, David, Shpall, Elizabeth J., Rezvani, Katayoun

“…Relapsed/refractory T-cell malignancies have a particularly poor prognosis and novel therapies are direly needed. CD5 is a great candidate for adoptive…”
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Author Correction: KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape by Li, Ye, Basar, Rafet, Wang, Guohui, Liu, Enli, Moyes, Judy S., Li, Li, Kerbauy, Lucila N., Uprety, Nadima, Fathi, Mohsen, Rezvan, Ali, Banerjee, Pinaki P., Muniz-Feliciano, Luis, Laskowski, Tamara J., Ensley, Emily, Daher, May, Shanley, Mayra, Mendt, Mayela, Acharya, Sunil, Liu, Bin, Biederstädt, Alexander, Rafei, Hind, Guo, Xingliang, Melo Garcia, Luciana, Lin, Paul, Ang, Sonny, Marin, David, Chen, Ken, Bover, Laura, Champlin, Richard E., Varadarajan, Navin, Shpall, Elizabeth J., Rezvani, Katayoun

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Generation of glucocorticoid-resistant SARS-CoV-2 T cells for adoptive cell therapy by Basar, Rafet, Uprety, Nadima, Ensley, Emily, Daher, May, Klein, Kimberly, Martinez, Fernando, Aung, Fleur, Shanley, Mayra, Hu, Bingqian, Gokdemir, Elif, Nunez Cortes, Ana Karen, Mendt, Mayela, Reyes Silva, Francia, Acharya, Sunil, Laskowski, Tamara, Muniz-Feliciano, Luis, Banerjee, Pinaki P., Li, Ye, Li, Sufang, Melo Garcia, Luciana, Lin, Paul, Shaim, Hila, Yates, Sean G., Marin, David, Kaur, Indreshpal, Rao, Sheetal, Mak, Duncan, Lin, Angelique, Miao, Qi, Dou, Jinzhuang, Chen, Ken, Champlin, Richard E., Shpall, Elizabeth J., Rezvani, Katayoun

“…Adoptive cell therapy with virus-specific T cells has been used successfully to treat life-threatening viral infections, supporting application of this…”
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Epigenetic Scarring Leads to Irreversible NK Cell Dysfunction in Myeloid Malignancies by Kumar, Bijender, Singh, Anand, Basar, Rafet, Uprety, Nadima, Li, Ye, Fan, Huihui, Shanley, Mayra, Acharya, Sunil, Mendt, Mayela Carolina, Lin, Paul, Biederstädt, Alexander, Rafei, Hind, Banerjee, Pinaki, Mohanty, Vakul, Shaim, Hila, Dede, Merve, Melo Garcia, Luciana, Kerbauy, Lucila Nassif, Nunez Cortes, Ana K., Miao, Qi, Dou, Jinzhuang, Silva Reyes, Francia, Guo, Xingliang, Kaplan, Mecit, Ang, Sonny, Jiang, Xin Ru, Liu, Enli, Liu, Bin, Champlin, Richard E., Kantarjian, Hagop, Marin, David, Chen, Ken, Abbas, Hussein A, Shpall, Elizabeth J., Rai, Kunal, Rezvani, Katayoun, Daher, MD, May

“…Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) belong to the same spectrum of myeloid malignancies and have extremely poor outcomes in the…”
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BATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML by Kumar, Bijender, Singh, Anand, Basar, Rafet, Uprety, Nadima, Li, Ye, Fan, Huihui, Cortes, Ana Karen Nunez, Kaplan, Mecit, Acharya, Sunil, Shaim, Hila, Xu, Anna C, Wu, Manrong, Ensley, Emily, Fang, Dexing, Banerjee, Pinaki P, Garcia, Luciana Melo, Tiberti, Silvia, Lin, Paul, Rafei, Hind, Munir, Maliha Nuzhat, Moore, Madison, Shanley, Mayra, Mendt, Mayela, Kerbauy, Lucila N, Liu, Bin, Biederstädt, Alexander, Gokdemir, Elif, Ghosh, Susmita, Kundu, Kiran, Reyes-Silva, Francia, Jiang, Xin Ru, Wan, Xinhai, Gilbert, April L, Dede, Merve, Mohanty, Vakul, Dou, Jinzhuang, Zhang, Patrick, Liu, Enli, Muniz-Feliciano, Luis, Deyter, Gary M, Jain, Abhinav K, Rodriguez-Sevilla, Juan Jose, Colla, Simona, Garcia-Manero, Guillermo, Shpall, Elizabeth J, Chen, Ken, Abbas, Hussein A, Rai, Kunal, Rezvani, Katayoun, Daher, May

“…Myelodysplastic syndrome and acute myeloid leukemia (AML) belong to a continuous disease spectrum of myeloid malignancies with poor prognosis in the…”
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A phase I/II clinical trial of autologous CMV-specific T cells in glioblastoma (GBM) patients to reveal a lack of immune effector function by Weathers, Shiao-Pei S., Penas-Prado, Marta, Banerjee, Pinaki Prosad, Bdiwi, Mustafa, Shaim, Hila, Alsuliman, Abdullah, Shanley, Mayra, Long, James, De Groot, John Frederick, O'Brien, Barbara Jane, Majd, Nazanin, Harrison, Rebecca A., Kamiya-Matsuoka, Carlos, Fuller, Gregory N., Chi, Linda, Rao, Ganesh, Lang, Frederick F., Shpall, Elizabeth J., Rezvani, Katayoun, Heimberger, Amy B.

“…Abstract only 2515 Background: Cytomegalovirus (CMV) antigens are present in > 90% of GBMs but not in normal brain making it an attractive immunological…”
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