Search Results - "Shanley, Daryl P."

A systems study reveals concurrent activation of AMPK and mTOR by amino acids by Dalle Pezze, Piero, Ruf, Stefanie, Sonntag, Annika G., Langelaar-Makkinje, Miriam, Hall, Philip, Heberle, Alexander M., Razquin Navas, Patricia, van Eunen, Karen, Tölle, Regine C., Schwarz, Jennifer J., Wiese, Heike, Warscheid, Bettina, Deitersen, Jana, Stork, Björn, Fäßler, Erik, Schäuble, Sascha, Hahn, Udo, Horvatovich, Peter, Shanley, Daryl P., Thedieck, Kathrin

“…Amino acids (aa) are not only building blocks for proteins, but also signalling molecules, with the mammalian target of rapamycin complex 1 (mTORC1) acting as…”
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Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis by Patel, Krutik, Barter, Matt, Soul, Jamie, Clark, Peter, Proctor, Carole, Clark, Ian, Young, David, Shanley, Daryl P

“…Changes in chondrocyte gene expression can contribute to the development of osteoarthritis (OA), and so recognition of the regulative processes during…”
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Genome‐Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR‐140‐5p by Barter, Matt J., Tselepi, Maria, Gómez, Rodolfo, Woods, Steven, Hui, Wang, Smith, Graham R., Shanley, Daryl P., Clark, Ian M., Young, David A.

“…microRNAs (miRNAs) are abundantly expressed in development where they are critical determinants of cell differentiation and phenotype. Accordingly miRNAs are…”
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An evolutionary perspective on the mechanisms of immunosenescence by Shanley, Daryl P, Aw, Danielle, Manley, Nancy R, Palmer, Donald B

“…There is an accumulating body of evidence that a decline in immune function with age is common to most if not all vertebrates. For instance, age-associated…”
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Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions by Dalle Pezze, Piero, Nelson, Glyn, Otten, Elsje G, Korolchuk, Viktor I, Kirkwood, Thomas B L, von Zglinicki, Thomas, Shanley, Daryl P

“…Cellular senescence, a state of irreversible cell cycle arrest, is thought to help protect an organism from cancer, yet also contributes to ageing. The changes…”
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Cytosolic Self-DNA-A Potential Source of Chronic Inflammation in Aging by Akbari, Mansour, Shanley, Daryl P, Bohr, Vilhelm A, Rasmussen, Lene Juel

“…Aging is the consequence of a lifelong accumulation of stochastic damage to tissues and cellular components. Advancing age closely associates with elevated…”
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A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation by Dalle Pezze, Piero, Sonntag, Annika G, Thien, Antje, Prentzell, Mirja T, Gödel, Markus, Fischer, Sven, Neumann-Haefelin, Elke, Huber, Tobias B, Baumeister, Ralf, Shanley, Daryl P, Thedieck, Kathrin

“…The kinase mammalian target of rapamycin (mTOR) exists in two multiprotein complexes (mTORC1 and mTORC2) and is a central regulator of growth and metabolism…”
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Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21-Mediated Early Senescence Signalling by Dolan, David W P, Zupanic, Anze, Nelson, Glyn, Hall, Philip, Miwa, Satomi, Kirkwood, Thomas B L, Shanley, Daryl P

“…Unrepaired or inaccurately repaired DNA damage can lead to a range of cell fates, such as apoptosis, cellular senescence or cancer, depending on the efficiency…”
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The DNA repair enzyme, aprataxin, plays a role in innate immune signaling by Madsen, Helena B, Pease, Louise I, Scanlan, Rebekah-Louise, Akbari, Mansour, Rasmussen, Lene J, Shanley, Daryl P, Bohr, Vilhelm A

“…Ataxia with oculomotor apraxia type 1 (AOA1) is a progressive neurodegenerative disorder characterized by a gradual loss of coordination of hand movements,…”
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Testing evolutionary theories of menopause by Shanley, Daryl P, Sear, Rebecca, Mace, Ruth, Kirkwood, Thomas B.L

“…Why do women cease fertility rather abruptly through menopause at an age well before generalized senescence renders child rearing biologically impossible? The…”
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Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways by Smith, Graham R, Shanley, Daryl P

“…FOXO transcription factors are an important, conserved family of regulators of cellular processes including metabolism, cell-cycle progression, apoptosis and…”
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Systems modelling ageing: from single senescent cells to simple multi-cellular models by Martinez Guimera, Alvaro, Welsh, Ciaran, Dalle Pezze, Piero, Fullard, Nicola, Nelson, Glyn, Roger, Mathilde F, Przyborski, Stefan A, Shanley, Daryl P

“…Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and…”
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Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts by Stamp, Craig, Zupanic, Anze, Sachdeva, Ashwin, Stoll, Elizabeth A., Shanley, Daryl P., Mathers, John C., Kirkwood, Thomas B.L., Heer, Rakesh, Simons, Benjamin D., Turnbull, Doug M., Greaves, Laura C.

“…Stem cell (SC) dynamics within the human colorectal crypt SC niche remain poorly understood, with previous studies proposing divergent hypotheses on the…”
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Systems modelling predicts chronic inflammation and genomic instability prevent effective mitochondrial regulation during biological ageing by Guimera, Alvaro Martinez, Clark, Peter, Wordsworth, James, Anugula, Sharath, Rasmussen, Lene Juel, Shanley, Daryl P.

“…The regulation of mitochondrial turnover under conditions of stress occurs partly through the AMPK-NAD+-PGC1α-SIRT1 signalling pathway. This pathway can be…”
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Modelling the role of redox-related mechanisms in musculoskeletal ageing by Guimera, Alvaro Martinez, Shanley, Daryl P., Proctor, Carole J.

“…The decline in the musculoskeletal system with age is driven at the cellular level by random molecular damage. Cells possess mechanisms to repair or remove…”
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Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community by Dalby, Matthew J., Pekovic‐Vaughan, Vanja, Shanley, Daryl P., Swift, Joe, White, Lisa J., Canty‐Laird, Elizabeth G.

“…Ageing causes progressive decline in metabolic, behavioural, and physiological functions, leading to a reduced health span. The extracellular matrix (ECM) is…”
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Altered oxidative DNA damage repair systems in muscles of old mice: role in the age‐related increase in muscle production of cytokines/chemokines by Kumiscia, Kat, Shigdar, Shahjahan, Owen, Euan, Staunton, Caroline A., Proctor, Carole J., Jackson, Malcolm J., Shanley, Daryl P., Iwanejko, Lesley A., McArdle, Anne

“…An increased presence of the oxidised DNA base lesion 8‐oxo‐7,8‐dihydroguanine (8‐oxoG) is seen in muscles of old mice. 8‐oxoG is repaired by the 8‐oxoguanine…”
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A modelling–experimental approach reveals insulin receptor substrate (IRS)‐dependent regulation of adenosine monosphosphate‐dependent kinase (AMPK) by insulin by Sonntag, Annika G., Dalle Pezze, Piero, Shanley, Daryl P., Thedieck, Kathrin

“…Mammalian target of rapamycin (mTOR) kinase responds to growth factors, nutrients and cellular energy status and is a central controller of cellular growth…”
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PyCoTools: a Python toolbox for COPASI by Welsh, Ciaran M, Fullard, Nicola, Proctor, Carole J, Martinez-Guimera, Alvaro, Isfort, Robert J, Bascom, Charles C, Tasseff, Ryan, Przyborski, Stefan A, Shanley, Daryl P

“…Abstract Motivation COPASI is an open source software package for constructing, simulating and analyzing dynamic models of biochemical networks. COPASI is…”
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‘Molecular habituation’ as a potential mechanism of gradual homeostatic loss with age by Martinez Guimera, Alvaro, Welsh, Ciaran M., Proctor, Carole J., McArdle, Anne, Shanley, Daryl P.

“…•Constitutive signals indicate homeostatic dysregulation but their effect on signal transduction remains largely unexplored.•A theoretical approach is…”
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