Search Results - "Shanks, Emma J."

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening by Mpamhanga, Chidochangu P, Spinks, Daniel, Tulloch, Lindsay B, Shanks, Emma J, Robinson, David A, Collie, Iain T, Fairlamb, Alan H, Wyatt, Paul G, Frearson, Julie A, Hunter, William N, Gilbert, Ian H, Brenk, Ruth

“…The enzyme pteridine reductase 1 (PTR1) is a potential target for new compounds to treat human African trypanosomiasis. A virtual screening campaign for…”
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Strategic siRNA screening approaches to target cancer at the Cancer Research UK Beatson Institute by Shanks, Emma J

“…The RNAi Screening Facility at the Cancer Research UK Beatson Institute combines siRNA genome-wide screening with drug screening coupled with High Content…”
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Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei by Spinks, Daniel, Shanks, Emma J., Cleghorn, Laura A. T., McElroy, Stuart, Jones, Deuan, James, Daniel, Fairlamb, Alan H., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H.

“…There is an urgent need for new drugs for the treatment of tropical parasitic diseases such as human African trypanosomiasis, which is caused by Trypanosoma…”
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Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase by Patterson, Stephen, Jones, Deuan C., Shanks, Emma J., Frearson, Julie A., Gilbert, Ian H., Wyatt, Paul G., Fairlamb, Alan H.

“…Thirty two analogues of phencyclidine were synthesised and tested as inhibitors of trypanothione reductase (TryR), a potential drug target in trypanosome and…”
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3q26‐29 Amplification in head and neck squamous cell carcinoma: a review of established and prospective oncogenes by Davidson, Matthew A., Shanks, Emma J.

“…Head and neck squamous cell carcinoma (HNSCC) is significantly underrepresented in worldwide cancer research, yet survival rates for the disease have remained…”
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Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography by Patterson, Stephen, Alphey, Magnus S, Jones, Deuan C, Shanks, Emma J, Street, Ian P, Frearson, Julie A, Wyatt, Paul G, Gilbert, Ian H, Fairlamb, Alan H

“…Trypanothione reductase (TryR) is a genetically validated drug target in the parasite Trypanosoma brucei, the causative agent of human African trypanosomiasis…”
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The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines by Gardner, Nicola J, Gillespie, Peter J, Carrington, Jamie T, Shanks, Emma J, McElroy, Stuart P, Haagensen, Emma J, Frearson, Julie A, Woodland, Andrew, Blow, J Julian

“…In late mitosis and G , origins of DNA replication must be "licensed" for use in the upcoming S phase by being encircled by double hexamers of the…”
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Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase by Shanks, Emma J., Ong, Han B., Robinson, David A., Thompson, Stephen, Sienkiewicz, Natasha, Fairlamb, Alan H., Frearson, Julie A.

“…Activity of the pterin- and folate-salvaging enzymes pteridine reductase 1 (PTR1) and dihydrofolate reductase–thymidylate synthetase (DHFR-TS) is commonly…”
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Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 by Spinks, Daniel, Ong, Han B., Mpamhanga, Chidochangu P., Shanks, Emma J., Robinson, David A., Collie, Iain T., Read, Kevin D., Frearson, Julie A., Wyatt, Paul G., Brenk, Ruth, Fairlamb, Alan H., Gilbert, Ian H.

“…Genetic studies indicate that the enzyme pteridine reductase 1 (PTR1) is essential for the survival of the protozoan parasite Trypanosoma brucei. Herein, we…”
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Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (ChemMedChem 8/2009) by Richardson, John L., Nett, Isabelle R. E., Jones, Deuan C., Abdille, Mohamed H., Gilbert, Ian H., Fairlamb, Alan H., Patterson, Stephen, Shanks, Emma J., Frearson, Julie A., Wyatt, Paul G.

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Cover Picture: Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase (ChemMedChem 2/2011) by Walton, Jeffrey G. A., Jones, Deuan C., Kiuru, Paula, Durie, Alastair J., Westwood, Nicholas J., Fairlamb, Alan H., Spinks, Daniel, Ong, Han B., Mpamhanga, Chidochangu P., Shanks, Emma J., Robinson, David A., Collie, Iain T., Read, Kevin D., Frearson, Julie A., Wyatt, Paul G., Brenk, Ruth, Fairlamb, Alan H., Gilbert, Ian H., Ruda, Gian Filippo, Nguyen, Corinne, Ziemkowski, Przemysław, Felczak, Krzysztof, Kasinathan, Ganasan, Musso-Buendia, Alexander, Sund, Christian, Zhou, Xiao Xiong, Kaiser, Marcel, Ruiz-Pérez, Luis M., Brun, Reto, Kulikowski, Tadeusz, Johansson, Nils Gunnar, González-Pacanowska, Dolores, Gilbert, Ian H.

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