Search Results - "Shankman, Laura"

Detection of histone modifications at specific gene loci in single cells in histological sections by Gomez, Delphine, Shankman, Laura S, Nguyen, Anh T, Owens, Gary K

“…A combination of in situ hybridization and a proximity ligation assay allows the visualization of histone modifications at single genomic loci with single-cell…”
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KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis by Shankman, Laura S, Gomez, Delphine, Cherepanova, Olga A, Salmon, Morgan, Alencar, Gabriel F, Haskins, Ryan M, Swiatlowska, Pamela, Newman, Alexandra A C, Greene, Elizabeth S, Straub, Adam C, Isakson, Brant, Randolph, Gwendalyn J, Owens, Gary K

“…A high percentage of smooth muscle cells in atherosclerotic lesions lose expression of smooth muscle marker proteins and acquire the phenotype of other cell…”
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A New Autosomal Myh11-CreERT2 Smooth Muscle Cell Lineage Tracing and Gene Knockout Mouse Model-Brief Report by Deaton, Rebecca A, Bulut, Gamze, Serbulea, Vlad, Salamon, Anita, Shankman, Laura S, Nguyen, Anh Tram, Owens, Gary K

“…BACKGROUNDThe Myh11 promoter is extensively used as a smooth muscle cell (SMC) Cre-driver and is regarded as the most restrictive and specific promoter…”
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Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective by Cherepanova, Olga A, Gomez, Delphine, Shankman, Laura S, Swiatlowska, Pamela, Williams, Jason, Sarmento, Olga F, Alencar, Gabriel F, Hess, Daniel L, Bevard, Melissa H, Greene, Elizabeth S, Murgai, Meera, Turner, Stephen D, Geng, Yong-Jian, Bekiranov, Stefan, Connelly, Jessica J, Tomilin, Alexey, Owens, Gary K

“…The pluripotency factor OCT4 is expressed in smooth muscle cells of atherosclerotic lesions in both mice and humans, and has atheroprotective effects in mice…”
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Efferocytosis by Paneth cells within the intestine by Shankman, Laura S., Fleury, Samantha T., Evans, W. Britt, Penberthy, Kristen K., Arandjelovic, Sanja, Blumberg, Richard S., Agaisse, Hervé, Ravichandran, Kodi S.

“…Apoptotic cells are quickly and efficiently engulfed and removed via the process of efferocytosis by either professional phagocytes, such as macrophages, or…”
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Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization by Rival, Claudia M., Xu, Wenhao, Shankman, Laura S., Morioka, Sho, Arandjelovic, Sanja, Lee, Chang Sup, Wheeler, Karen M., Smith, Ryan P., Haney, Lisa B., Isakson, Brant E., Purcell, Scott, Lysiak, Jeffrey J., Ravichandran, Kodi S.

“…Fertilization is essential for species survival. Although Izumo1 and Juno are critical for initial interaction between gametes, additional molecules necessary…”
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A New Autosomal Myh11-CreER T2 Smooth Muscle Cell Lineage Tracing and Gene Knockout Mouse Model—Brief Report by Deaton, Rebecca A., Bulut, Gamze, Serbulea, Vlad, Salamon, Anita, Shankman, Laura S., Nguyen, Anh Tram, Owens, Gary K.

“…The promoter is extensively used as a smooth muscle cell (SMC) Cre-driver and is regarded as the most restrictive and specific promoter available to study…”
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ELMO1 signaling is a promoter of osteoclast function and bone loss by Arandjelovic, Sanja, Perry, Justin S. A., Zhou, Ming, Ceroi, Adam, Smirnov, Igor, Walk, Scott F., Shankman, Laura S., Cambré, Isabelle, Onengut-Gumuscu, Suna, Elewaut, Dirk, Conrads, Thomas P., Ravichandran, Kodi S.

“…Osteoporosis affects millions worldwide and is often caused by osteoclast induced bone loss. Here, we identify the cytoplasmic protein ELMO1 as an important…”
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KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation by Bulut, Gamze B., Alencar, Gabriel F., Owsiany, Katherine M., Nguyen, Anh T., Karnewar, Santosh, Haskins, Ryan M., Waller, Lillian K., Cherepanova, Olga A., Deaton, Rebecca A., Shankman, Laura S., Keller, Susanna R., Owens, Gary K.

“…OBJECTIVE:Smooth muscle cells and pericytes display remarkable plasticity during injury and disease progression. Here, we tested the hypothesis that…”
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Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality by Karnewar, Santosh, Karnewar, Vaishnavi, Shankman, Laura S, Owens, Gary K

“…The use of senolytic agents to remove senescent cells from atherosclerotic lesions is controversial. A common limitation of previous studies is the failure to…”
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Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition by Shamsuzzaman, Sohel, Deaton, Rebecca A, Salamon, Anita, Doviak, Heather, Serbulea, Vlad, Milosek, Victoria M, Evans, Megan A, Karnewar, Santosh, Saibaba, Subhi, Alencar, Gabriel F, Shankman, Laura S, Walsh, Kenneth, Bekiranov, Stefan, Kocher, Olivier, Krieger, Monty, Kull, Bengt, Persson, Marie, Michaëlsson, Erik, Bergenhem, Nils, Heydarkhan-Hagvall, Sepideh, Owens, Gary K

“…Thromboembolic events, including myocardial infarction (MI) or stroke, caused by the rupture or erosion of unstable atherosclerotic plaques are the leading…”
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IL-1β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice by Karnewar, Santosh, Karnewar, Vaishnavi, Deaton, Rebecca A, Shankman, Laura S, Benavente, Ernest D, Williams, Corey M, Bradley, Xenia, Alencar, Gabriel F, Bulut, Gamze B, Kirmani, Sara, Baylis, Richard A, Zunder, Eli R, den Ruijter, Hester M, Pasterkamp, Gerard, Owens, Gary K

“…Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions is the global leading cause of death. The most common and effective…”
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Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms by Newman, Alexandra A. C., Serbulea, Vlad, Baylis, Richard A., Shankman, Laura S., Bradley, Xenia, Alencar, Gabriel F., Owsiany, Katherine, Deaton, Rebecca A., Karnewar, Santosh, Shamsuzzaman, Sohel, Salamon, Anita, Reddy, Mahima S., Guo, Liang, Finn, Aloke, Virmani, Renu, Cherepanova, Olga A., Owens, Gary K.

“…Stable atherosclerotic plaques are characterized by a thick, extracellular matrix-rich fibrous cap populated by protective ACTA2 + myofibroblast (MF)-like…”
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A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis by Arandjelovic, Sanja, Perry, Justin S. A., Lucas, Christopher D., Penberthy, Kristen K., Kim, Tae-Hyoun, Zhou, Ming, Rosen, Dorian A, Chuang, Tzu-Ying, Bettina, Alexandra M., Shankman, Laura S., Cohen, Amanda H., Gaultier, Alban, Conrads, Thomas P., Kim, Minsoo, Elliott, Michael R., Ravichandran, Kodi S.

“…Rheumatoid arthritis is characterized by progressive joint inflammation and affects ~1% of the human population. We noted single-nucleotide polymorphisms…”
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Context-dependent compensation among phosphatidylserine-recognition receptors by Penberthy, Kristen K., Rival, Claudia, Shankman, Laura S., Raymond, Michael H., Zhang, Jianye, Perry, Justin S. A., Lee, Chang Sup, Han, Claudia Z., Onengut-Gumuscu, Suna, Palczewski, Krzysztof, Lysiak, Jeffrey J., Ravichandran, Kodi S.

“…Phagocytes express multiple phosphatidylserine (PtdSer) receptors that recognize apoptotic cells. It is unknown whether these receptors are interchangeable or…”
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Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis by Shankman, Laura S, Gomez, Delphine, Cherepanova, Olga A, Salmon, Morgan, Alencar, Gabriel F, Haskins, Ryan M, Swiatlowska, Pamela, Newman, Alexandra A C, Greene, Elizabeth S, Straub, Adam C, Isakson, Brant, Randolph, Gwendalyn J, Owens, Gary K

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Irradiation abolishes smooth muscle investment into vascular lesions in specific vascular beds by Newman, Alexandra Ac, Baylis, Richard A, Hess, Daniel L, Griffith, Steven D, Shankman, Laura S, Cherepanova, Olga A, Owens, Gary K

“…The long-term adverse effects of radiotherapy on cardiovascular disease are well documented. However, the underlying mechanisms responsible for this increased…”
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Combining Multiple Annotations to Count Cells in 3D Cardiovascular Immunofluorescent Images by Adorno, William, Shankman, Laura S., Brown, Donald E.

“…Cell quantification in 3D atherosclerotic plaque immunofluorescent images is critical in improving understanding of plaque composition and possibly preventing…”
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Cooperative Binding of KLF4, pELK-1, and HDAC2 to a G/C Repressor Element in the SM22α Promoter Mediates Transcriptional Silencing During SMC Phenotypic Switching In Vivo by Salmon, Morgan, Gomez, Delphine, Greene, Elizabeth, Shankman, Laura, Owens, Gary K

“…RATIONALE:We previously identified conserved G/C Repressor elements in the promoters of most smooth muscle cell (SMC) marker genes and demonstrated that…”
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A new autosomal Myh11-CreERT2 smooth muscle cell lineage tracing and gene knockout mouse model by Deaton, Rebecca A., Bulut, Gamze, Serbulea, Vlad, Salamon, Anita, Shankman, Laura S., Nguyen, Anh Tram, Owens, Gary K.

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